公开(公告)号：US20060084014A1

公开(公告)日：2006-04-20

申请号：US11247960

申请日：2005-10-11

Applicant: Huibert van Boxtel ,  Akira Kase ,  Yasuo Iwasa ,  Yuzo Toda

Inventor： Huibert van Boxtel ,  Akira Kase ,  Yasuo Iwasa ,  Yuzo Toda

IPC: G03C1/46

CPC classification number: G03C7/346

Abstract: A colour photographic material is disclosed comprising a black image forming coupler substituted in the 2, 4 and/or 6 position shown by formula (I) or formula (II), where in LINK represents a divalent linking group, BALL represents a group that prevents the coupler from diffusing away from the layer containing it. X and Y each represent a hydrogen atom or a coupling-off group capable of being released upon an oxidative coupling reaction with a developing agent. The material has a good colour reproduction and excellent light stability.

Abstract translation: 公开了一种彩色照相材料，其包括在式（I）或式（II）所示的2,4和/或6位置取代的黑色成像成色剂，其中LINK表示二价连接基团，BALL表示防止 耦合器从包含它的层扩散。 X和Y各自表示与显影剂的氧化偶联反应时能够释放的氢原子或偶联离子基团。 该材料具有良好的色彩再现性和优异的光稳定性。

公开(公告)号：US07323294B2

公开(公告)日：2008-01-29

申请号：US11247960

申请日：2005-10-11

Applicant: Huibert Albertus van Boxtel ,  Akira Kase ,  Yasuo Iwasa ,  Yuzo Toda

Inventor： Huibert Albertus van Boxtel ,  Akira Kase ,  Yasuo Iwasa ,  Yuzo Toda

IPC: G03C5/18 ,  G03C1/005 ,  G03C1/494 ,  G03C1/08

CPC classification number: G03C7/346

Abstract: A color photographic material is disclosed comprising a black image forming coupler substituted in the 2, 4 and/or 6 position shown by formula (I) or formula (II), where in LINK represents a divalent linking group, BALL represents a group that prevents the coupler from diffusing away from the layer containing it. X and Y each represent a hydrogen atom or a coupling-off group capable of being released upon an oxidative coupling reaction with a developing agent. The material has a good color reproduction and excellent light stability.

Abstract translation: 公开了一种彩色照相材料，其包括在式（I）或式（II）所示的2,4和/或6位置取代的黑色成像成色剂，其中LINK表示二价连接基团，BALL表示防止 耦合器从包含它的层扩散。 X和Y各自表示与显影剂的氧化偶联反应时能够释放的氢原子或偶联离子基团。 该材料具有良好的色彩再现性和优异的光稳定性。

公开(公告)号：US20050287314A1

公开(公告)日：2005-12-29

申请号：US11149982

申请日：2005-06-10

Applicant: Joseph Hubertus Olijve ,  Bernadette Catharina Anna Maria van der Velden-Schuermans ,  Akira Kase ,  Yoichiro Kamiyama ,  Yuzo Toda

Inventor： Joseph Hubertus Olijve ,  Bernadette Catharina Anna Maria van der Velden-Schuermans ,  Akira Kase ,  Yoichiro Kamiyama ,  Yuzo Toda

IPC: B41M5/00 ,  B41M5/50 ,  B41M5/52

CPC classification number: B41M5/5236 ,  B41M5/506 ,  B41M5/5254

Abstract: The present invention relates to a recording medium, in particular an ink-jet recording medium of photographic quality that has excellent ink absorption speed, good drying characteristics, and a good image printing quality. According to the present invention, an ink-jet recording medium is provided, comprising a support in which a water-swellable layer is adhered, comprising gelatin and a hydrophilic polymer. The present invention is further directed to methods for obtaining such a medium.

Abstract translation: 本发明涉及一种记录介质，特别是具有优异的吸墨速度，良好的干燥特性和良好的图像打印质量的照相质量的喷墨记录介质。 根据本发明，提供一种喷墨记录介质，其包括其中粘附有水溶胀层的载体，其包含明胶和亲水性聚合物。 本发明还涉及获得这种介质的方法。

公开(公告)号：US07670839B2

公开(公告)日：2010-03-02

申请号：US10540167

申请日：2003-12-23

Applicant: Jan Bastiaan Bouwstra ,  Andries Johannes Jozef Van Es ,  Yuzo Toda

Inventor： Jan Bastiaan Bouwstra ,  Andries Johannes Jozef Van Es ,  Yuzo Toda

IPC: C12N5/00 ,  C07K14/00

CPC classification number: C12N5/0075 ,  C07K14/78 ,  C12N2533/54

Abstract: The invention relates to a support for culturing cells, in particular to microcarriers coated with gelatine or gelatine-like proteins. Such microcarriers serve as support for culturing anchorage dependent cells. In particular the invention relates to a process for the preparation of a cell culture support comprising the step of coating a microcarrier bead with gelatine or gelatine-like protein, said gelatine or gelatine-like protein having a molecular weight of about 40 kDa to about 200 kDa.

Abstract translation: 本发明涉及培养细胞的载体，特别涉及用明胶或明胶样蛋白包被的微载体。 这种微载体用作培养依赖于锚定细胞的载体。 特别地，本发明涉及一种制备细胞培养支持物的方法，其包括用明胶或明胶样蛋白包被微载体珠的步骤，所述明胶或明胶样蛋白具有约40kDa至约200的分子量 kDa。

公开(公告)号：US07179885B2

公开(公告)日：2007-02-20

申请号：US10451897

申请日：2001-12-21

Applicant: Jan Bastiaan Bouwstra ,  Gertjan Bögels ,  Yuzo Toda

Inventor： Jan Bastiaan Bouwstra ,  Gertjan Bögels ,  Yuzo Toda

IPC: C07K14/78 ,  G03C1/005 ,  G03C1/047

CPC classification number: C07K14/78 ,  G03C1/0051 ,  G03C1/047

Abstract: Silver halide emulsions for photographic uses contain a nucleation peptiser having at least one region A of up to 100 amino acids. Region A can either consist of (i) at least two silver-binding amino acids and up to 98 amino acids between the two silver-binding amino acids, or can consist of (ii) a stretch of from 9 to 100 amino acids having a polarity corresponding to an average transfer free energy ΔF equal to or higher than +1.0 kcal/mol. The nucleation peptizer also has at least one region B (separated from region A) having at least 50 amino acids and having a polarity corresponding to an average transfer free energy equal to or lower than −1.0 kcal/mol and not containing methionine residues. The emulsion may also contain a growth peptiser having similar characteristics to the nucleation peptiser, but having a longer A region and a greater overall length.

Abstract translation: 用于照相用途的卤化银乳剂含有具有至多一个至多100个氨基酸的区域A的成核胶溶剂。 区域A可以由（i）至少两个结合银的氨基酸和两个结合银的氨基酸之间的至多98个氨基酸组成，或者可以由（ii）具有9至100个氨基酸的片段组成，其具有 对应于等于或高于+1.0kcal / mol的平均转移自由能ΔF的极性。 成核胶溶剂还具有至少一个具有至少50个氨基酸并具有对应于等于或低于-1.0kcal / mol的平均转移自由能的极性并且不含有甲硫氨酸残基的至少一个区域B（与区域A分离）。 该乳液还可含有具有与成核胶溶剂相似的特征但具有较长A区和更长总长的生长胶溶剂。

公开(公告)号：US08080515B2

公开(公告)日：2011-12-20

申请号：US12494450

申请日：2009-06-30

Applicant: Jan Bastiaan Bouwstra ,  Andries Johannes Jozef Van Es ,  Yuzo Toda

Inventor： Jan Bastiaan Bouwstra ,  Andries Johannes Jozef Van Es ,  Yuzo Toda

IPC: C07K14/00

CPC classification number: A61K9/5078 ,  A61K9/1658 ,  A61K47/42 ,  C07K14/78 ,  C12N5/0075 ,  C12N2533/30 ,  C12N2533/54

Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.

Abstract translation: 本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。 更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。 优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。 本发明还涉及用于与整联蛋白连接的RGD富集的明胶。 特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。 此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

公开(公告)号：US07671016B2

公开(公告)日：2010-03-02

申请号：US11770271

申请日：2007-06-28

Applicant: Jan Bastiaan Bouwstra ,  Andries Johannes Jozef Van Es ,  Yuzo Toda

Inventor： Jan Bastiaan Bouwstra ,  Andries Johannes Jozef Van Es ,  Yuzo Toda

IPC: C07K14/00

CPC classification number: A61K9/5078 ,  A61K9/1658 ,  A61K47/42 ,  C07K14/78 ,  C12N5/0075 ,  C12N2533/30 ,  C12N2533/54

Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.

Abstract translation: 本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。 更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。 优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。 本发明还涉及用于与整联蛋白连接的RGD富集的明胶。 特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。 此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

公开(公告)号：US20050119170A1

公开(公告)日：2005-06-02

申请号：US10469747

申请日：2002-03-06

Applicant: Jan Bouwstra ,  Yuzo Toda

Inventor： Jan Bouwstra ,  Yuzo Toda

IPC: A61K47/04 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/06 ,  A61K33/42 ,  A61K38/17 ,  A61K38/39 ,  A61K47/26 ,  A61K47/48 ,  A61P7/08

CPC classification number: A61K33/06 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/42 ,  A61K38/39 ,  A61K2300/00

Abstract: The invention relates to compositions suitable for plasma substitution comprising as a plasma expander a recombinant gelatin-like protein. Characteristic is that the gelatin-like protein essentially is free of hydroxyproline. This absence of hydroxyproline prevents the composition from gelling and thus allows the use of high-molecular weight proteins in order to establish a suitable colloid osmotic pressure. Specific advantage of the gelatin-like proteins is that these avoid the risk of anaphylactic shock that exists in conjunction with the use of commercially available preparations.

Abstract translation: 本发明涉及适用于血浆置换的组合物，其包含作为血浆扩张剂的重组明胶样蛋白。 特征是明胶样蛋白质基本上不含羟脯氨酸。 这种羟基脯氨酸的缺乏防止了组合物凝胶化，从而允许使用高分子量蛋白质以建立合适的胶体渗透压。 明胶样蛋白质的具体优点在于，这些避免与使用市售制剂一起存在的过敏性休克的风险。

公开(公告)号：US06627667B2

公开(公告)日：2003-09-30

申请号：US09898723

申请日：2001-07-03

Applicant: Sebastianus Gerardus J. M. Kluijtmans ,  Jan Bastiaan Bouwstra ,  Yuzo Toda

Inventor： Sebastianus Gerardus J. M. Kluijtmans ,  Jan Bastiaan Bouwstra ,  Yuzo Toda

IPC: C08J520

CPC classification number: G03C1/053 ,  C08B15/06 ,  C08H1/06 ,  G03C1/04 ,  G03C1/047

Abstract: The invention is directed to a process for modifying a water soluble polymer, said process comprising modifying a polymer containing amine groups, by reacting at least one of said amine groups with activated ester, said ester being the reaction product of a carboxyl activator and the carboxyl group of a molecule R—COOH, said R-group being a functional group, to produce a reaction mixture containing a polymer, said polymer containing at least one amide group; subjecting said reaction mixture to at least ion exchange chromatography to purify said reaction mixture, said purification comprising at least partly removing the said reaction product, and/or carboxyl activator.

Abstract translation: 本发明涉及一种改性水溶性聚合物的方法，所述方法包括通过使至少一种所述胺基与活性酯反应来修饰含有胺基团的聚合物，所述酯是羧基活化剂与羧基的反应产物 的分子R-COOH，所述R基团是官能团，以产生含有聚合物的反应混合物，所述聚合物含有至少一个酰胺基团;将所述反应混合物至少进行离子交换色谱以纯化所述反应混合物， 所述纯化包括至少部分除去所述反应产物和/或羧基活化剂。

公开(公告)号：US07645737B2

公开(公告)日：2010-01-12

申请号：US11770197

申请日：2007-06-28

Applicant: Jan Bastiaan Bouwstra ,  Andries Johannes Jozef Van Es ,  Yuzo Toda

Inventor： Jan Bastiaan Bouwstra ,  Andries Johannes Jozef Van Es ,  Yuzo Toda

IPC: C07K14/00

CPC classification number: A61K9/5078 ,  A61K9/1658 ,  A61K47/42 ,  C07K14/78 ,  C12N5/0075 ,  C12N2533/30 ,  C12N2533/54

Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.

Abstract translation: 本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。 更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。 优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。 本发明还涉及用于与整联蛋白连接的RGD富集的明胶。 特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。 此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。