公开(公告)号：US20070031501A1

公开(公告)日：2007-02-08

申请号：US10566878

申请日：2004-08-04

Applicant: Andries Van Es ,  Jan Bouwstra ,  Yuzo Toda

Inventor： Andries Van Es ,  Jan Bouwstra ,  Yuzo Toda

IPC: A61K9/14 ,  C07K14/78

CPC classification number: A61K47/42 ,  A61K9/19

Abstract: The invention relates to the use of gelatin-like proteins, or polypeptides, with an increased calculated glass transition temperature as stabilisers in lyophilized biological or pharmaceutical compositions.

Abstract translation: 本发明涉及具有增加的计算玻璃化转变温度的明胶样蛋白或多肽在冻干生物或药物组合物中作为稳定剂的用途。

公开(公告)号：US20050101531A1

公开(公告)日：2005-05-12

申请号：US10658989

申请日：2003-09-10

Applicant: Jan Bouwstra ,  Yuzo Toda

Inventor： Jan Bouwstra ,  Yuzo Toda

IPC: A61K38/00 ,  A61P7/08 ,  C07K14/78 ,  A61K38/42

CPC classification number: C07K14/78 ,  A61K38/00

Abstract: The invention relates to compositions suitable for plasma substitution comprising as a plasma expander a recombinant gelatin-like protein. Characteristic is that the gelatin-like protein can be a monomer or a polymer like a dimer, trimer or a tetramer of a human recombinant gelatin-like protein having an isolectric point of less than 8. The resulting gelatin-like proteins provide a method to control the clearance rate of a plasma expander by its molecular weight. Preferably the gelatin-like proteins have a low hydroxyproline content which prevents the composition from gelling and thus allows the use of high-molecular weight proteins in order to establish a suitable colloid osmotic pressure. An additional advantage of the gelatin-like proteins is that these avoid the risk of anaphylactic shock that exists in conjunction with the use of commercially available preparations.

Abstract translation: 本发明涉及适用于血浆置换的组合物，其包含作为血浆扩张剂的重组明胶样蛋白。 特征在于，明胶样蛋白质可以是单体或聚合物，如具有小于8的等电点的人重组明胶样蛋白质的二聚体，三聚体或四聚体。所得明胶样蛋白质提供了一种方法， 通过分子量控制等离子体膨胀机的清除率。 优选地，明胶样蛋白质具有低羟脯氨酸含量，其防止组合物胶凝，因此允许使用高分子量蛋白质以建立合适的胶体渗透压。 明胶样蛋白质的另外的优点是这些避免了与使用市售制剂一起存在的过敏性休克的风险。

公开(公告)号：US20050150602A1

公开(公告)日：2005-07-14

申请号：US10929721

申请日：2004-08-31

Applicant: Hindrik DeVries ,  Jan Bouwstra

Inventor： Hindrik DeVries ,  Jan Bouwstra

IPC: B01J19/08 ,  C08J7/00 ,  C23C16/455 ,  H05H1/24 ,  C23F1/00

CPC classification number: H05H1/46 ,  H05H2001/4675 ,  H05H2001/4697 ,  H05H2001/485

Abstract: Method of generating an atmospheric pressure glow discharge plasma (APG), wherein said plasma is generated in a discharge space formed between at least one first electrode surface and at least one second electrode surface. The method comprises at least the steps of supplying a gaseous substance to said discharge space and powering said first and said second electrode surface for generating said plasma. Said step of supplying a gaseous substance to the discharge space comprises providing at least one intermediate gas supply stream from at least one of said first and second electrode surfaces. The step of supplying said gaseous substance to the discharge space further comprises providing a main gas supply stream for forcing the at least one intermediate gas supply stream in a direction along the first and second electrode surfaces.

Abstract translation: 产生大气压辉光放电等离子体（APG）的方法，其中所述等离子体在形成于至少一个第一电极表面和至少一个第二电极表面之间的放电空间中产生。 该方法至少包括以下步骤：向所述放电空间供应气态物质，并为所述第一和第二电极表面供电以产生所述等离子体。 将所述气态物质供应到所述放电空间的步骤包括从所述第一和第二电极表面中的至少一个提供至少一个中间气体供应流。 将所述气态物质供应到放电空间的步骤还包括提供主气体供应流，用于迫使所述至少一个中间气体供应流沿着第一和第二电极表面的方向。

公开(公告)号：US20050119170A1

公开(公告)日：2005-06-02

申请号：US10469747

申请日：2002-03-06

Applicant: Jan Bouwstra ,  Yuzo Toda

Inventor： Jan Bouwstra ,  Yuzo Toda

IPC: A61K47/04 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/06 ,  A61K33/42 ,  A61K38/17 ,  A61K38/39 ,  A61K47/26 ,  A61K47/48 ,  A61P7/08

CPC classification number: A61K33/06 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/42 ,  A61K38/39 ,  A61K2300/00

Abstract: The invention relates to compositions suitable for plasma substitution comprising as a plasma expander a recombinant gelatin-like protein. Characteristic is that the gelatin-like protein essentially is free of hydroxyproline. This absence of hydroxyproline prevents the composition from gelling and thus allows the use of high-molecular weight proteins in order to establish a suitable colloid osmotic pressure. Specific advantage of the gelatin-like proteins is that these avoid the risk of anaphylactic shock that exists in conjunction with the use of commercially available preparations.

Abstract translation: 本发明涉及适用于血浆置换的组合物，其包含作为血浆扩张剂的重组明胶样蛋白。 特征是明胶样蛋白质基本上不含羟脯氨酸。 这种羟基脯氨酸的缺乏防止了组合物凝胶化，从而允许使用高分子量蛋白质以建立合适的胶体渗透压。 明胶样蛋白质的具体优点在于，这些避免与使用市售制剂一起存在的过敏性休克的风险。

公开(公告)号：US20060204511A1

公开(公告)日：2006-09-14

申请号：US10567078

申请日：2004-08-04

Applicant: Jan Bouwstra ,  Yuzo Toda ,  Andries Van Es

Inventor： Jan Bouwstra ,  Yuzo Toda ,  Andries Van Es

IPC: A61K39/00

CPC classification number: A61K47/34

Abstract: The invention relates to methods for preparing vaccine and pharmaceutical compositions comprising recombinant or synthetic gelatin as a stabiliser and to the vaccine and pharmaceutical formulations themselves, as prepared by these methods.

Abstract translation: 本发明涉及制备包含重组或合成明胶作为稳定剂的疫苗和药物组合物的方法以及通过这些方法制备的疫苗和药物制剂本身。

公开(公告)号：US20060204457A1

公开(公告)日：2006-09-14

申请号：US10546590

申请日：2004-02-25

Applicant: Yuzo Toda ,  Sebastianus Gerardus Kluijtmans ,  Jan Bouwstra

Inventor： Yuzo Toda ,  Sebastianus Gerardus Kluijtmans ,  Jan Bouwstra

IPC: A61K8/64

CPC classification number: A61K8/65 ,  A61K8/4926 ,  A61K8/496 ,  A61K2800/57 ,  A61Q17/04

Abstract: This invention relates to a cosmetic composition for protection against UV radiation and its detrimental effects comprising a cosmetically and dermatologically acceptable carrier and a UV absorbing compound, not being flavonoid, which is covalently linked to a carrier molecule.

Abstract translation: 本发明涉及一种用于防止紫外线辐射的化妆品组合物及其有害作用，其包括美容和皮肤病学上可接受的载体以及与载体分子共价连接的不是类黄酮的紫外线吸收化合物。

公开(公告)号：US20060181592A1

公开(公告)日：2006-08-17

申请号：US11340417

申请日：2006-01-26

Applicant: Iskandar Gandasasmita ,  Andries van Es ,  Jan Bouwstra ,  Yoichiro Kamiyama ,  Yuzo Toda ,  Antonius Josephus Kemperman ,  Geert Koops

Inventor： Iskandar Gandasasmita ,  Andries van Es ,  Jan Bouwstra ,  Yoichiro Kamiyama ,  Yuzo Toda ,  Antonius Josephus Kemperman ,  Geert Koops

IPC: B41J3/407

CPC classification number: B41M5/502 ,  B41M5/506 ,  B41M5/508 ,  B41M5/5227 ,  B41M5/5236 ,  B41M5/5254

Abstract: The present invention relates to a recording medium, in particular an ink-jet recording medium of photographic quality that has excellent ink absorption speed, good drying characteristics and a good image printing quality. According to the present invention, an ink-jet recording medium is provided, comprising a support and an ink-receiving layer which has an asymmetric membrane structure comprising a dense top layer adjacent to a microporous sublayer, said ink-receiving layer comprising at least one water-swellable polymer. The present invention is further directed to methods for obtaining such a medium.

Abstract translation: 本发明涉及一种记录介质，特别是具有优异的吸墨速度，良好的干燥特性和良好的图像打印质量的照相品质的喷墨记录介质。 根据本发明，提供了一种喷墨记录介质，其包括支撑体和油墨接收层，其具有包括邻近微孔子层的致密顶层的不对称膜结构，所述油墨接收层包括至少一个 水溶胀性聚合物。 本发明还涉及获得这种介质的方法。

公开(公告)号：US20060083760A1

公开(公告)日：2006-04-20

申请号：US10672040

申请日：2003-09-26

Applicant: Joseph Olijve ,  Jan Bouwstra ,  Frederik Wolf De ,  Marc Werten ,  Hendrik Wisselink ,  Richele Wind ,  Tanja Bosch Van Den ,  Yuzo Toda

Inventor： Joseph Olijve ,  Jan Bouwstra ,  Frederik Wolf De ,  Marc Werten ,  Hendrik Wisselink ,  Richele Wind ,  Tanja Bosch Van Den ,  Yuzo Toda

IPC: A61K8/65

CPC classification number: G03C1/005

Abstract: The invention provides oil-in-water emulsions comprising recombinant collagen-like polymer in an amount sufficient to act as stabiliser of the emulsion. The polymer is especially a polypeptide which is free of helix structure, has an isoelectric point at least 0.5 pH units removed from the pH of the oil-in-water emulsion. Furthermore, amphiphilic recombinant collagen-like polymers are provided for use in oil-in-water emulsions. The amphiphilic polymers are polar at one end as a result of a relative abundance of polar amino acids, and apolar at the other end as a result of a relative abundance of apolar amino acids.

Abstract translation: 本发明提供了包含足以作为乳液稳定剂的量的重组胶原样聚合物的水包油乳液。 聚合物特别是不含螺旋结构的多肽，具有从水包油乳液的pH去除至少0.5个pH单位的等电点。 此外，提供两亲重组胶原样聚合物用于水包油乳剂中。 由于极性氨基酸的相对丰度，两亲聚合物在一端是极性的，另一端由于非极性氨基酸的相对丰度而非极性。

公开(公告)号：US20060081566A1

公开(公告)日：2006-04-20

申请号：US11202366

申请日：2005-08-12

Applicant: Hindrik DeVries ,  Yoichiro Kamiyama ,  Jan Bouwstra ,  Mauritius Van de Sanden ,  Eugen Aldea ,  Paul Peeters

Inventor： Hindrik DeVries ,  Yoichiro Kamiyama ,  Jan Bouwstra ,  Mauritius Van de Sanden ,  Eugen Aldea ,  Paul Peeters

IPC: B23K9/00 ,  B23K9/02

CPC classification number: H01J37/32018 ,  H01J37/32045 ,  H05H1/46 ,  H05H2001/4682 ,  H05H2001/4697

Abstract: The present invention is directed to a method and arrangement for controlling a glow discharge plasma in a gas or gas mixture under atmospheric conditions, in a plasma discharge space comprising at least two spaced electrodes (2), wherein at least one plasma pulse having an absolute pulse maximum is generated by applying an AC plasma energizing voltage to the electrodes (2) causing a plasma current and a displacement current. The plasma is controlled by providing a relative decrease of the displacement current after the pulse maximum. In a preferred embodiment, the energizing voltage is applied through a series circuit of a choke coil (3) and a non-saturable inductor (4).

Abstract translation: 本发明涉及一种用于在包括至少两个间隔开的电极（2）的等离子体放电空间中在大气条件下控制气体或气体混合物中的辉光放电等离子体的方法和装置，其中至少一个等离子体脉冲具有绝对 通过对电极（2）施加AC等离子体激励电压而产生等离子体电流和位移电流来产生脉冲最大值。 通过在脉冲最大值之后提供相对减小的位移电流来控制等离子体。 在优选实施例中，通过扼流线圈（3）和不可饱和电感器（4）的串联电路施加通电电压。

公开(公告)号：US20060022606A1

公开(公告)日：2006-02-02

申请号：US10917515

申请日：2004-08-13

Applicant: Hindrik DeVries ,  Jan Bouwstra ,  Eugen Aldea ,  Mauritius Van De Sanden

Inventor： Hindrik DeVries ,  Jan Bouwstra ,  Eugen Aldea ,  Mauritius Van De Sanden

IPC: G09G3/10

CPC classification number: H05H1/2406 ,  H05H2001/2412 ,  H05H2001/2437

Abstract: The present invention provides an arrangement and method for generating a uniform and stable plasma. The arrangement comprises a discharge space (7) between at least a pair of electrodes (1, 2), which electrodes (1, 2) are arranged for providing an electric field and for generating a plasma in the electric field. At least one of the electrodes (1) has a boundary surface (6) with the discharge space (7). The boundary surface is comprised of one or more alternately arranged conductive (4) and insulating regions (5). The invention further relates to an electrode (1) for use in the arrangement described. The invention may, for example, be used in dielectric barrier discharge configurations, or in arrangements for generating plasmas at atmospheric pressures, or for generating plasmas at low temperatures, such as generating atmospheric pressure glow plasmas (APG) for material processing or surface (3) treatment purposes.

Abstract translation: 本发明提供了一种用于产生均匀且稳定的等离子体的装置和方法。 该装置包括在至少一对电极（1,2）之间的放电空间（7），该电极（1,2）被布置用于提供电场并用于在电场中产生等离子体。 电极（1）中的至少一个具有带放电空间（7）的边界面（6）。 边界面由一个或多个交替布置的导电（4）和绝缘区（5）组成。 本发明还涉及用于所述装置的电极（1）。 本发明可以例如用于介电阻挡放电结构，或用于在大气压下产生等离子体的装置中，或用于在低温下产生等离子体，例如产生用于材料加工或表面（3）的大气压辉光等离子体（APG） ）治疗目的。