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1.发明申请公开(公告)号：US20140187801A1
公开(公告)日：2014-07-03
申请号：US13729479
申请日：2012-12-28
发明人： Albert Sun-Chi Chan , Baomin Fan , Jun Wang , Chengyuan Lin , Chao Huang , Qingjing Yang , Jianbin Xu , Zhaoxiang Bian , Aiping Lu , Jun Hu
IPC分类号： C07D493/08
CPC分类号： C07D493/08
摘要： The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.
摘要翻译： 本发明涉及一种去甲斑idin素类似物的类型，以及通过7-氧杂苯并苯并异戊二烯的过渡金属催化的炔化反应来合成去甲斑idin素类似物的方法。 本发明还涉及这种去甲斑ar素类似物在制备用于治疗癌症肿瘤的药物中的用途。
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公开(公告)号：US09783519B2
公开(公告)日：2017-10-10
申请号：US14743209
申请日：2015-06-18
发明人： Zhaoxiang Bian , Chengyuan Lin , Huaixue Mu , Baomin Fan , Yongyun Zhou , Jingchao Chen , Aiping Lu , Albert Sun-Chi Chan
IPC分类号： C07D319/00 , A61K38/00 , C07D319/22 , C07D317/70 , A61K31/12 , A61K31/357 , A61K31/36
CPC分类号： C07D319/22 , A61K31/12 , A61K31/357 , A61K31/36 , C07D317/70
摘要： This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds comprising phenylacetophenone derivatives using oxabenzonorbornadienes with terminal alkynes.
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3.发明申请USE OF A FLAVANOL GLYCOSIDE FOR SUPPRESSING ACTIVATION OF STELLATE CELLS 有权用于抑制铁酸盐细胞活化的FLAVANOL GLYCOSIDE的用途公开(公告)号：US20140348965A1
公开(公告)日：2014-11-27
申请号：US13899713
申请日：2013-05-22
发明人： Zhaoxiang Bian , Siu Wai Tsang , Hongjie Zhang , Yegao Chen , Aiping Lu , Albert Sun-Chi Chan , Hongxi Xu , Shilin Chen , Dajian Yang
IPC分类号： C07H1/08 , A61K36/12 , A61K31/7048 , C07H17/065
CPC分类号： C07H17/065 , A61K31/7048 , A61K36/12 , A61K2236/00
摘要： A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
摘要翻译： 用于抑制受试者胰岛细胞活化的方法包括给予包含治疗有效量的Eruberin A的组合物。预防，减轻或治疗胰腺肿瘤或胰腺肿瘤相关疾病的方法包括给予包含治疗有效量 Eruberin A.可以从蒲公英中提取Eruberin A。
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4.发明授权Method of using dihydro-resveratrol for treating acute pancreatitis and associated pulmonary injury 有权使用二氢白藜芦醇治疗急性胰腺炎及相关性肺损伤的方法公开(公告)号：US09526706B1
公开(公告)日：2016-12-27
申请号：US14740410
申请日：2015-06-16
发明人： Zhaoxiang Bian , Siu Wai Tsang , Hongjie Zhang , Aiping Lu , Albert Sun-Chi Chan
CPC分类号： A61K31/09 , A61K31/05 , C07C37/003 , C07C39/15
摘要： The present invention relates to a method of using trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.
摘要翻译： 本发明涉及使用反式-3,5,4'-三羟基联苄（也称为二氢白藜芦醇）在需要的受试者中治疗急性胰腺炎的方法。 更具体地说，本发明涉及使用二氢白藜芦醇及其衍生物和/或化学变体作为补救剂的方法。 本发明特别涉及用于治疗受试者的急性胰腺炎相关肺损伤的组织损伤的改善。
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公开(公告)号：US09260466B2
公开(公告)日：2016-02-16
申请号：US13899713
申请日：2013-05-22
发明人： Zhaoxiang Bian , Siu Wai Tsang , Hongjie Zhang , Yegao Chen , Aiping Lu , Albert Sun-Chi Chan , Hongxi Xu , Shilin Chen , Dajian Yang
IPC分类号： A61K36/11 , C07H17/065 , A61K31/7048 , A61K36/12
CPC分类号： C07H17/065 , A61K31/7048 , A61K36/12 , A61K2236/00
摘要： A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
摘要翻译： 用于抑制受试者胰岛细胞活化的方法包括给予包含治疗有效量的Eruberin A的组合物。预防，减轻或治疗胰腺肿瘤或胰腺肿瘤相关疾病的方法包括给予包含治疗有效量 Eruberin A.可以从蒲公英中提取Eruberin A。
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公开(公告)号：US08652540B2
公开(公告)日：2014-02-18
申请号：US13831990
申请日：2013-03-15
发明人： Zhaoxiang Bian , Siu Wai Tsang , Aiping Lu , Haitao Xiao , Hongyan Qin , Albert Sun-Chi Chan , Hongxi Xu , Shilin Chen , Dajian Yang
IPC分类号： A01N65/00
CPC分类号： A61K31/192 , A61K36/708 , A61K2300/00
摘要： The present invention relates to a method of using an anthraquinone derivative namely 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, or known as Rhein, for treating chronic pancreatitis induced fibrosis of the pancreas. More particularly, the present invention relates to a method of using Rhein, its derivatives and/or chemical variants as an anti-fibrotic agent. The present invention particularly relates to the suppression of pancreatic stellate cell activation for the management of chronic inflammatory, fibrotic and tumorigenic pathologies in the pancreas.
摘要翻译： 本发明涉及使用蒽醌衍生物即9,10-二氢-4,5-二羟基-9,10-二氧代-2-蒽甲酸（或称为莱茵），用于治疗慢性胰腺炎诱导的胰腺纤维化的方法 。 更具体地，本发明涉及使用莱茵，其衍生物和/或化学变体作为抗纤维化剂的方法。 本发明特别涉及抑制胰岛细胞活化，用于治疗胰腺中的慢性炎症，纤维化和致瘤性病理。
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7.发明授权Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities 有权去甲斑anth素的异构合成通过炔基苯并苯并噻二唑的炔化反应及其抗癌活性公开(公告)号：US08835658B2
公开(公告)日：2014-09-16
申请号：US13729479
申请日：2012-12-28
发明人： Albert Sun-Chi Chan , Baomin Fan , Jun Wang , Chengyuan Lin , Chao Huang , Qingjing Yang , Jianbin Xu , Zhaoxiang Bian , Aiping Lu , Jun Hu
IPC分类号： C07D307/00 , C07D493/08
CPC分类号： C07D493/08
摘要： The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.
摘要翻译： 本发明涉及一种去甲斑idin素类似物的类型，以及通过7-氧杂苯并苯并异戊二烯的过渡金属催化的炔化反应来合成去甲斑idin素类似物的方法。 本发明还涉及这种去甲斑ar素类似物在制备用于治疗癌症肿瘤的药物中的用途。
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