专利检索 ap:("HONG KONG BAPTIST UNIVERSITY" OR "YUNNAN UNIVERSITY OF NATIONALITIES") AND inv:"Jun Wang" 第 1 页

1.

发明申请
ASYMETRIC SYNTHESIS OF NORCANTHARIDIN ANALOUGUS BY ALKYNYLATION OF OXABENZONORBORNADIENES AND THEIR ANTICANCER ACTIVITIES 有权
标题翻译：异恶唑烷酮联合化合物的异黄酮合成及其反应活性

公开(公告)号：US20140187801A1

公开(公告)日：2014-07-03

申请号：US13729479

申请日：2012-12-28

申请人： HONG KONG BAPTIST UNIVERSITY , YUNNAN UNIVERSITY OF NATIONALITIES

发明人： Albert Sun-Chi Chan , Baomin Fan , Jun Wang , Chengyuan Lin , Chao Huang , Qingjing Yang , Jianbin Xu , Zhaoxiang Bian , Aiping Lu , Jun Hu

IPC分类号： C07D493/08

CPC分类号： C07D493/08

摘要： The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.

摘要翻译： 本发明涉及一种去甲斑idin素类似物的类型，以及通过7-氧杂苯并苯并异戊二烯的过渡金属催化的炔化反应来合成去甲斑idin素类似物的方法。本发明还涉及这种去甲斑ar素类似物在制备用于治疗癌症肿瘤的药物中的用途。

2.

发明授权
Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities 有权
标题翻译：去甲斑anth素的异构合成通过炔基苯并苯并噻二唑的炔化反应及其抗癌活性

公开(公告)号：US08835658B2

公开(公告)日：2014-09-16

申请号：US13729479

申请日：2012-12-28

申请人： Hong Kong Baptist University , Yunnan University of Nationalities

发明人： Albert Sun-Chi Chan , Baomin Fan , Jun Wang , Chengyuan Lin , Chao Huang , Qingjing Yang , Jianbin Xu , Zhaoxiang Bian , Aiping Lu , Jun Hu

IPC分类号： C07D307/00 , C07D493/08

CPC分类号： C07D493/08

摘要： The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.

摘要翻译： 本发明涉及一种去甲斑idin素类似物的类型，以及通过7-氧杂苯并苯并异戊二烯的过渡金属催化的炔化反应来合成去甲斑idin素类似物的方法。本发明还涉及这种去甲斑ar素类似物在制备用于治疗癌症肿瘤的药物中的用途。

3.

发明授权
Flavan-3-ol analogs and anti-inflammatory activity 有权

公开(公告)号：US11952358B2

公开(公告)日：2024-04-09

申请号：US18055873

申请日：2022-11-16

申请人： Hong Kong Baptist University

发明人： Jun Wang , Zihao Wang , Qingjing Yang , Zhaoxiang Bian

IPC分类号： C07D311/62 , C07D311/58 , C07D407/04

CPC分类号： C07D311/62 , C07D311/58 , C07D407/04 , C07B2200/05

摘要： Provided herein are compounds useful in the treatment of inflammatory diseases, pharmaceutical compositions comprising the same, and methods of use and preparation thereof. The compounds exhibit inhibitory effects on the expression and secretion of pro-inflammatory cytokines, such as IL-1β, IL-6 and TNF-α.