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1.发明申请公开(公告)号：US20140187801A1
公开(公告)日：2014-07-03
申请号：US13729479
申请日：2012-12-28
发明人： Albert Sun-Chi Chan , Baomin Fan , Jun Wang , Chengyuan Lin , Chao Huang , Qingjing Yang , Jianbin Xu , Zhaoxiang Bian , Aiping Lu , Jun Hu
IPC分类号： C07D493/08
CPC分类号： C07D493/08
摘要： The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.
摘要翻译： 本发明涉及一种去甲斑idin素类似物的类型，以及通过7-氧杂苯并苯并异戊二烯的过渡金属催化的炔化反应来合成去甲斑idin素类似物的方法。 本发明还涉及这种去甲斑ar素类似物在制备用于治疗癌症肿瘤的药物中的用途。
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2.发明授权Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities 有权去甲斑anth素的异构合成通过炔基苯并苯并噻二唑的炔化反应及其抗癌活性公开(公告)号：US08835658B2
公开(公告)日：2014-09-16
申请号：US13729479
申请日：2012-12-28
发明人： Albert Sun-Chi Chan , Baomin Fan , Jun Wang , Chengyuan Lin , Chao Huang , Qingjing Yang , Jianbin Xu , Zhaoxiang Bian , Aiping Lu , Jun Hu
IPC分类号： C07D307/00 , C07D493/08
CPC分类号： C07D493/08
摘要： The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.
摘要翻译： 本发明涉及一种去甲斑idin素类似物的类型，以及通过7-氧杂苯并苯并异戊二烯的过渡金属催化的炔化反应来合成去甲斑idin素类似物的方法。 本发明还涉及这种去甲斑ar素类似物在制备用于治疗癌症肿瘤的药物中的用途。
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3.发明授权(+)-3′-angeloyloxy-4′-keto-3′,4′-dihydroseselin for treating inflammation 有权（+） - 3'-酰基氧基-4'-酮-3'，4'-二氢肾上腺素用于治疗炎症公开(公告)号：US09408828B2
公开(公告)日：2016-08-09
申请号：US14742727
申请日：2015-06-18
发明人： Zhaoxiang Bian , Huaixue Mu , Chengyuan Lin , Quanbin Han , Aiping Lu , Linfang Huang , Shilin Chen , Dajian Yang , Hongxi Xu , Sun Chi Albert Chan
IPC分类号： A61K31/37 , A61K31/366 , A61K9/00
CPC分类号： A61K31/366 , A61K9/0053 , A61K31/37
摘要： The present invention provides a compound, namely (+)-3′-Angeloyloxy-4′-keto-3′,4′-dihydroseselin (Pd-Ib) derived from Bupleurum malconense as the potential anti-inflammation drug. The present invention also relates to methods of preparing the compounds and using the same for treating inflammation.
摘要翻译： 本发明提供一种化合物，即作为潜在的抗炎药物的源自柴胡子的（+） - 3'-酰基氧基-4'-酮-3'，4'-二氢塞来林（Pd-Ib）化合物。 本发明还涉及制备化合物并使用该化合物治疗炎症的方法。
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公开(公告)号：US10376555B2
公开(公告)日：2019-08-13
申请号：US15925949
申请日：2018-03-20
发明人： Zhaoxiang Bian , Tao Huang , Chengyuan Lin
IPC分类号： C07K5/12 , C07K7/08 , A61K38/10 , A61K38/12 , A61K38/02 , A61K38/22 , A61K38/00 , A61K38/17 , A61K9/00 , A61P3/04
摘要： Cyclic peptide agonists toward human galanin receptor 2 (GalR2) and galanin receptor 3 (GalR3) based on hidden conformation of spexin solution structure for GalR2 and GalR3-related and spexin-deficient disorders are designed and synthesized. LH101, LH102, and LH101 (Ac) are potent spexin analogs with prolonged action, which can be used in the treatment of GalR2 and GalR3-related diseases and spexin-deficient disorders, such as obesity.
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公开(公告)号：US20170014438A1
公开(公告)日：2017-01-19
申请号：US15190367
申请日：2016-06-23
发明人： Zhaoxiang Bian , Huaixue Mu , Chengyuan Lin , Jinjin Wang , Zhijun Yang , Aiping Lu , Albert Sun Chi Chan
IPC分类号： A61K31/7048 , A61K36/888 , A61K9/00
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/0053 , A61K31/09 , A61K31/34 , A61K31/341 , A61K31/353 , A61K36/888
摘要： The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root of Lasia spinosa Linn. Thwait or chemically synthesized and its specific anticancer/antitumor activity. This invention has a specific application in treating human esophageal cancer.
摘要翻译： 本发明涉及具有抗增殖性质的生物活性成分。 具体地说，本发明涉及一种分离自蚕豆根茎的黄酮醇化合物。 等待或化学合成及其特异性抗癌/抗肿瘤活性。 本发明在治疗人食管癌方面具有特殊的应用。
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公开(公告)号：US20160375082A1
公开(公告)日：2016-12-29
申请号：US15190587
申请日：2016-06-23
发明人： Zhaoxiang Bian , Huaixue Mu , Chengyuan Lin , Hongxi Xu , Dajian Yang , Shilin Chen , Aiping Lu , Albert Sun Chi Chan
IPC分类号： A61K36/888 , A61K9/00 , A61K31/34 , A61K31/09 , A61K31/341
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/0053 , A61K31/09 , A61K31/34 , A61K31/341 , A61K31/353 , A61K36/888
摘要： The present invention relates to chemical constituents of the hydro-alcoholic extract of root of Lasia spinosa (L.) Thwait. More particularly, it relates to the bioactive chemical composition of Lasia spinosa (L.) Thwait and its anticancer effect. The present invention has application in the treatment of human esophageal carcinoma.
摘要翻译： 本发明涉及拉丝刺（Th。Thwait）根的含水醇提取物的化学成分。 更具体地说，它涉及Lasia spinosa（L.）Thwait的生物活性化学成分及其抗癌作用。 本发明可应用于人食管癌的治疗。
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7.发明申请Bioactivity proanthocyanidin compound isolated from Lasia spinosa (L.) Thwait 审中-公开从Lasia spinosa（L.）Thwait分离的生物活性原花青素化合物公开(公告)号：US20160374985A1
公开(公告)日：2016-12-29
申请号：US15190812
申请日：2016-06-23
发明人： Zhaoxiang Bian , Huaixue Mu , Chengyuan Lin , Hongxi Xu , Dajian Yang , Shilin Chen , Aiping Lu , Albert Sun Chi Chan
IPC分类号： A61K31/353 , A61K9/00 , A61K36/888
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/0053 , A61K31/09 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/353 , A61K36/888
摘要： The present invention disclosed a compound, proanthocyanidin A1 (PA1), which is isolated from Lasia spinosa (L.) Thwait, for its effects in shortening of clolon length, reducing colonic tissue damage, suppressing colonic myeloperoxidase activity with colitis. The said compound can be used in treating inflammatory diseases and anti-cancer leading compound.
摘要翻译： 本发明公开了一种从Lasia spinosa（L.）Thwait中分离出的化合物原花青素A1（PA1），其用于缩短clolon长度，降低结肠组织损伤，抑制结肠炎的结肠髓过氧化物酶活性的作用。 所述化合物可用于治疗炎性疾病和抗癌化合物。
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公开(公告)号：US09655913B2
公开(公告)日：2017-05-23
申请号：US15190367
申请日：2016-06-23
发明人： Zhaoxiang Bian , Huaixue Mu , Chengyuan Lin , Jinjin Wang , Zhijun Yang , Aiping Lu , Albert Sun Chi Chan
IPC分类号： A61K31/7048 , A61K36/888 , A61K31/09 , A61K31/341 , A61K31/34 , A61K9/00 , A61K31/353
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/0053 , A61K31/09 , A61K31/34 , A61K31/341 , A61K31/353 , A61K36/888
摘要： The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root of Lasia spinosa Linn. Thwait or chemically synthesized and its specific anticancer/antitumor activity. This invention has a specific application in treating human esophageal cancer.
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公开(公告)号：US09783519B2
公开(公告)日：2017-10-10
申请号：US14743209
申请日：2015-06-18
发明人： Zhaoxiang Bian , Chengyuan Lin , Huaixue Mu , Baomin Fan , Yongyun Zhou , Jingchao Chen , Aiping Lu , Albert Sun-Chi Chan
IPC分类号： C07D319/00 , A61K38/00 , C07D319/22 , C07D317/70 , A61K31/12 , A61K31/357 , A61K31/36
CPC分类号： C07D319/22 , A61K31/12 , A61K31/357 , A61K31/36 , C07D317/70
摘要： This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds comprising phenylacetophenone derivatives using oxabenzonorbornadienes with terminal alkynes.
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公开(公告)号：US09775857B2
公开(公告)日：2017-10-03
申请号：US15190587
申请日：2016-06-23
发明人： Zhaoxiang Bian , Huaixue Mu , Chengyuan Lin , Hongxi Xu , Dajian Yang , Shilin Chen , Aiping Lu , Albert Sun Chi Chan
IPC分类号： A61K36/00 , A61K31/7048 , A61K36/888 , A61K31/09 , A61K31/341 , A61K31/34 , A61K9/00 , A61K31/353
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/0053 , A61K31/09 , A61K31/34 , A61K31/341 , A61K31/353 , A61K36/888
摘要： The present invention relates to chemical constituents of the hydro-alcoholic extract of root of Lasia spinosa (L.) Thwait. More particularly, it relates to the bioactive chemical composition of Lasia spinosa (L.) Thwait and its anticancer effect. The present invention has application in the treatment of human esophageal carcinoma.
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