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公开(公告)号：US12030952B2
公开(公告)日：2024-07-09
申请号：US17664609
申请日：2022-05-23
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2887 , A61P25/00 , C07K16/2881 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/66 , C07K2317/92 , C07K2317/94
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20230365702A1
公开(公告)日：2023-11-16
申请号：US18132486
申请日：2023-04-10
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2881 , C07K16/18 , C07K16/468 , A61P25/28 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/64 , A61K2039/505
摘要： Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US11787873B2
公开(公告)日：2023-10-17
申请号：US16744697
申请日：2020-01-16
发明人： Rebecca Croasdale-Wood , Lydia Jasmin Hanisch , Guy Georges , Thomas Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Samuel Moser , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Claudio Sustmann , Pablo Umana
IPC分类号： C07K16/32 , A61K31/713 , C12N5/10 , C12N15/63 , A61K39/00
CPC分类号： C07K16/32 , A61K31/713 , C12N5/10 , C12N15/63 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US11787868B2
公开(公告)日：2023-10-17
申请号：US17130477
申请日：2020-12-22
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2881 , A61P25/28 , C07K16/18 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/64
摘要： Herein are provided bispecific anti-human A-betalhuman transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US10793621B2
公开(公告)日：2020-10-06
申请号：US15961699
申请日：2018-04-24
发明人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
摘要： The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.
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公开(公告)号：US10323099B2
公开(公告)日：2019-06-18
申请号：US15092847
申请日：2016-04-07
摘要： Multispecific antibodies based on antibodies that share a common light chain are described herein. The multispecific antibodies include: modified heavy chains having, by domain exchange, a common light chain variable domain VL; and two modified light chains having, by domain exchange, variable heavy chain domains of a first antibody (VH1) and a second antibody (VH2), wherein one light chain is of kappa isotype and one light chain is of lambda isotype. The present invention also relates to methods for the manufacture of such antibodies and their use.
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公开(公告)号：US09914776B2
公开(公告)日：2018-03-13
申请号：US14816252
申请日：2015-08-03
发明人： Oliver Ast , Marina Bacac , Sabine Imhof-Jung , Christiane Jaeger , Christian Klein , Stefan Klostermann , Michael Molhoj , Joerg Thomas Regula , Wolfgang Schaefer , Pablo Umana
IPC分类号： C07K16/28 , A61K39/395 , C07K16/30 , C07K16/32
CPC分类号： C07K16/2809 , C07K16/2878 , C07K16/2887 , C07K16/3053 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US20170114146A1
公开(公告)日：2017-04-27
申请号：US15282994
申请日：2016-09-30
发明人： Christian Klein , Wolfgang Schaefer , Stefan Klostermann , Sabine Imhof-Jung , Michael Molhoj , Joerg Thomas Regula , Tanja Fauti , Charles Dumontet , Pablo Umana , Marina Bacac , Anne Freimoser-Grundschober
CPC分类号： C07K16/3061 , A61K2039/505 , A61K2039/57 , C07K16/2803 , C07K16/2809 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/66 , C07K2317/71 , C07K2317/73 , C07K2317/75 , C07K2317/92 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US11999801B2
公开(公告)日：2024-06-04
申请号：US16821747
申请日：2020-03-17
发明人： Ulrich Brinkmann , Wolfgang Schaefer , Klaus Mayer
IPC分类号： C07K16/46 , A61K39/395 , C07K16/28 , C07K16/30 , C07K16/32 , C07K16/44 , G01N33/53 , A61K39/00
CPC分类号： C07K16/468 , A61K39/395 , C07K16/2803 , C07K16/2878 , C07K16/2896 , C07K16/303 , C07K16/32 , C07K16/44 , G01N33/53 , A61K2039/505 , C07K2317/35 , C07K2317/524 , C07K2317/55 , C07K2317/56 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2319/70 , C07K2319/72
摘要： The present invention relates to multispecific antibodies comprising at least three antigen binding sites wherein the third binding site is disulfide stabilized by introduction of cysteine, method for their production, pharmaceutical compositions containing said antibodies and uses thereof.
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公开(公告)号：US20230399391A1
公开(公告)日：2023-12-14
申请号：US18150616
申请日：2023-01-05
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine lmhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/565 , C07K2317/622 , C07K2317/31 , C07K2317/76 , C07K2317/73 , C07K2319/30 , C07K2319/00 , C07K2317/21 , C07K2317/56
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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