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    Method for determining whether reconstitution of a solution in a container is completed
    3.
    发明授权
    Method for determining whether reconstitution of a solution in a container is completed 有权

    公开(公告)号：US10209211B2

    公开(公告)日：2019-02-19

    申请号：US15321508

    申请日：2015-06-26

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Tobias Werk ,  Jörg Lümkemann ,  René Rietmann ,  Roger Steiner ,  Hanns-Christian Mahler

    IPC: G01N27/07 ,  G01N27/06 ,  G01N33/15 ,  G01N13/00

    Abstract: A method for determining whether reconstitution of a solution in a container is completed comprises the steps of: selecting a predetermined amount of a solid substance and a predetermined amount of a liquid solvent from which the reconstituted solution is to be prepared, preparing a solution by solving the predetermined amount of the solid substance in the predetermined amount of the liquid solvent, measuring the impedance (Z) or the resistance (R) of the solution, determining whether the change of the measured impedance (Z) or the resistance (R) within a measuring time interval of a predetermined duration is below a defined threshold, and determining that reconstitution of the solution is completed when the change of the measured impedance (Z) is below the defined threshold.

    Multi chamber syringe unit
    6.
    发明授权
    Multi chamber syringe unit 有权

    公开(公告)号：US11357914B2

    公开(公告)日：2022-06-14

    申请号：US16075536

    申请日：2017-02-03

    Applicant: HOFFMANN-LA ROCHE INC.

    Inventor： Jörg Lümkemann ,  Tobias Werk

    IPC: A61M5/19 ,  A61M5/178 ,  A61M5/31 ,  A61J1/20 ,  A61M5/28

    Abstract: A multi chamber syringe unit includes a body, a separating element and a bypass arrangement. The body has a distal end side, a proximal end side opposite to the distal end side, an interior limited by a side wall between the distal end side and the proximal end side and a longitudinal axis centrally extending from the distal end side to the proximal end side through the body. The separating element is arranged in the interior of the body forming a distal chamber between the distal end side and the separating element and a proximal chamber between the proximal end side and the separating element. The bypass arrangement is a section of the body in which the interior has a constant noncircular cross section orthogonal to the longitudinal axis. The multi camber syringe unit allows for being efficiently prepared and for efficiently providing or administering high quality of prefilled products.

    Preparing a double chamber container
    8.
    发明授权
    Preparing a double chamber container 有权

    公开(公告)号：US11072446B2

    公开(公告)日：2021-07-27

    申请号：US15531898

    申请日：2015-12-04

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Tobias Werk ,  Jörg Lümkemann ,  Hanns-Christian Mahler

    IPC: B65B7/28 ,  B65B3/00

    Abstract: A method of preparing a double chamber container is disclosed that includes filling a substance into the container, freeze-drying the substance therein, inserting a middle plunger in the container to form distal and proximal chambers, wherein the middle plunger seals the distal chamber from the proximal chamber and the freeze-dried substance is inside the distal chamber. The method includes filling a reconstitution medium in the proximal chamber, and sealing distal and proximal openings of the container. The method includes providing a holder having a seat and arranging the container in the seat in an upright position wherein a distal end side of the container extends downwardly and a proximal end side of the container extends upwardly. The container is arranged in the seat while the substance is filled, the substance is freeze-dried, the middle plunger is inserted, the reconstitution medium is filled, and the proximal opening is sealed.

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