知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

340 条记录 (耗时 0.02 秒)

    "> POLYMORPHS OF N-(6-(4-CHLOROPHENOXY)HEXYL)-N'-CYANO-N
    2.
    发明申请
    POLYMORPHS OF N-(6-(4-CHLOROPHENOXY)HEXYL)-N'-CYANO-N"-(4-PYRIDYL)GUANIDINE, AND PREPARATION THEREOF AND USE THEREOF 有权
    N-（6-（4-氯苯氧基）己基）-N'-氰基-N“ - （4-吡啶基）胍的聚合物及其制备及其用途

    公开(公告)号：US20130281494A1

    公开(公告)日：2013-10-24

    申请号：US13881706

    申请日：2011-10-25

    申请人： Hesheng Zhang ,  Xin Chen

    发明人： Hesheng Zhang ,  Xin Chen

    IPC分类号： C07D213/75

    CPC分类号： C07D213/75

    摘要： Disclosed are a polymorphs I-VI of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine or of a solvate thereof, a preparation method thereof, and a use thereof as a biological active ingredient. The polymorphs are useful in treatment of cancers, and diseases or disorders caused by abnormal cell proliferation.

    摘要翻译： 公开了N-（6-（4-氯苯氧基）己基）-N'-氰基-N“ - （4-吡啶基）胍或其溶剂化物的多晶型物I-VI，其制备方法和用途 作为生物活性成分。 多晶型物可用于治疗由异常细胞增殖引起的癌症和疾病或病症。

    Polymorphs of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine, and preparation thereof and use thereof
    4.
    发明授权
    Polymorphs of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine, and preparation thereof and use thereof 有权
    N-（6-（4-氯苯氧基）己基）-N'-氰基-N“ - （4-吡啶基）胍的多晶型物及其制备及其用途

    公开(公告)号：US08859594B2

    公开(公告)日：2014-10-14

    申请号：US13881706

    申请日：2011-10-25

    申请人： Hesheng Zhang ,  Xin Chen

    发明人： Hesheng Zhang ,  Xin Chen

    IPC分类号： C07D213/75 ,  C07D213/74 ,  A61K31/4409 ,  A61P35/00

    CPC分类号： C07D213/75

    摘要： Disclosed are a polymorphs I-VI of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine or of a solvate thereof, a preparation method thereof, and a use thereof as a biological active ingredient. The polymorphs are useful in treatment of cancers, and diseases or disorders caused by abnormal cell proliferation.

    摘要翻译： 公开了N-（6-（4-（4-氯苯氧基）己基）-N'-氰基-N“ - （4-吡啶基）胍或其溶剂合物的多晶型物I-VI及其制备方法及其用途 作为生物活性成分。 多晶型物可用于治疗由异常细胞增殖引起的癌症和疾病或病症。

    POLYMORPHS OF DALFAMPRIDINE, PREPARATIONS AND USES THEREOF
    5.
    发明申请
    POLYMORPHS OF DALFAMPRIDINE, PREPARATIONS AND USES THEREOF 审中-公开
    达乐康的多聚体，制备及其用途

    公开(公告)号：US20130197040A1

    公开(公告)日：2013-08-01

    申请号：US13878422

    申请日：2011-10-08

    申请人： Hesheng Zhang ,  Xin Chen

    发明人： Hesheng Zhang ,  Xin Chen

    IPC分类号： C07D213/73

    CPC分类号： C07D213/73 ,  A61K31/44

    摘要： Provided are polymorphs I to VIII of a dalfampridine or of its solvates, a preparation method therefore, and applications thereof as an active component of a medicine. Said polymorphs Ito VIII of the dalfampridine or of its solvents can be used to prepare formulations for improving the walking speed of patients of multiple sclerosis and for alleviating other symptoms of multiple sclerosis.

    摘要翻译： 提供了dalfampidine或其溶剂化物的多晶型物I至VIII，因此其制备方法及其作为药物的活性成分的应用。 dalfampridine或其溶剂的所述多晶型物Ito VIII可用于制备用于改善多发性硬化患者的行走速度并减轻多发性硬化症的其他症状的制剂。

    Guided Wave Non-Destructive Testing Using Magnetostrictive Sensor with Moving Magnet and Partial Activation of Magnetostrictive Strip
    6.
    发明公开
    Guided Wave Non-Destructive Testing Using Magnetostrictive Sensor with Moving Magnet and Partial Activation of Magnetostrictive Strip 审中-公开

    公开(公告)号：US20240027403A1

    公开(公告)日：2024-01-25

    申请号：US18357142

    申请日：2023-07-23

    申请人： Sergey Vinogradov ,  Xin Chen ,  Jay Fisher

    发明人： Sergey Vinogradov ,  Xin Chen ,  Jay Fisher

    IPC分类号： G01N29/24 ,  G01N29/265

    CPC分类号： G01N29/2412 ,  G01N29/265 ,  G01N2291/044 ,  G01N2291/0422

    摘要： A “partial activation” method of magnetostrictive guided wave testing of a structure. A coil-wrapped magnetostrictive strip is acoustically coupled to the surface of the structure. A permanent magnet is placed over a portion of the strip, such that the permanent magnet covers all or most of the width of the strip but only a portion of its length. A pulsed alternating current source activates the magnetostrictive strip, thereby producing magnetostrictive vibrations in the magnetostrictive strip, and thereby resulting in guided waves in the structure. Response signals are received, then the permanent magnet is moved to a next position along the length of the magnetostrictive strip. As the magnet is moved along the strip, the strip is activated and response signals are received, thereby testing a desired portion of the structure under the strip. The response signals are analyzed to determine the presence of anomalies in the structure.

    Synchronization method and system for single event list type data in PET imaging
    8.
    发明授权
    Synchronization method and system for single event list type data in PET imaging 有权

    公开(公告)号：US10930031B2

    公开(公告)日：2021-02-23

    申请号：US14408935

    申请日：2012-08-14

    申请人： Qingguo Xie ,  Yuanbao Chen ,  Jun Zhu ,  Xin Chen ,  Zhongyi Wu ,  Luyao Wang

    发明人： Qingguo Xie ,  Yuanbao Chen ,  Jun Zhu ,  Xin Chen ,  Zhongyi Wu ,  Luyao Wang

    IPC分类号： G06T11/00 ,  G01T1/29 ,  A61B6/03

    摘要： A method for synchronizing list-mode data of single events in a PET imaging includes: acquiring list-mode data of single events of each independent detector module, calculating a probability density of time intervals between occurrences of single events in detector module and setting initial parameters, determining detection starting time difference of each detector module with iterative peak searching and graded time window, and performing synchronization correction and coincidence discrimination on the single event data in each detector module based on the detection starting time difference. A system for synchronizing list-mode data of single events in a PET imaging includes: a data acquisition and frequency difference compensation module, an initial parameter setting module, a coarse time scale coincidence module, a fine time scale coincidence module and a data synchronization correction and coincidence discrimination module.

    Measuring tissue shear wave properties using one excitation pulse and excitation pulses having different widths and shapes
    10.
    发明授权
    Measuring tissue shear wave properties using one excitation pulse and excitation pulses having different widths and shapes 有权

    公开(公告)号：US10327739B2

    公开(公告)日：2019-06-25

    申请号：US15090357

    申请日：2016-04-04

    申请人： Yi Zheng ,  Siping Chen ,  Tianfu Wang ,  Xin Chen ,  Haoming Lin

    发明人： Yi Zheng ,  Siping Chen ,  Tianfu Wang ,  Xin Chen ,  Haoming Lin

    IPC分类号： A61B8/08 ,  G01S7/52 ,  G01S7/62

    摘要： Ultrasound radiation using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location. The detection location can be at one point at a time for imaging two-dimensional or three-dimensional tissue nonlinearities and shear wave properties including nonlinear magnitude variations, nonlinear phase variations, nonlinear coefficients, and viscoelasticity. The induced shear wave are detected at multiple locations along the shear propagation directions for calculating different shear group velocities and different shear phase velocities using different excitation pulses, and calculating nonlinearity and viscoelasticity.