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    "> POLYMORPHS OF N-(6-(4-CHLOROPHENOXY)HEXYL)-N'-CYANO-N
    3.
    发明申请
    POLYMORPHS OF N-(6-(4-CHLOROPHENOXY)HEXYL)-N'-CYANO-N"-(4-PYRIDYL)GUANIDINE, AND PREPARATION THEREOF AND USE THEREOF 有权
    N-（6-（4-氯苯氧基）己基）-N'-氰基-N“ - （4-吡啶基）胍的聚合物及其制备及其用途

    公开(公告)号：US20130281494A1

    公开(公告)日：2013-10-24

    申请号：US13881706

    申请日：2011-10-25

    申请人： Hesheng Zhang ,  Xin Chen

    发明人： Hesheng Zhang ,  Xin Chen

    IPC分类号： C07D213/75

    CPC分类号： C07D213/75

    摘要： Disclosed are a polymorphs I-VI of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine or of a solvate thereof, a preparation method thereof, and a use thereof as a biological active ingredient. The polymorphs are useful in treatment of cancers, and diseases or disorders caused by abnormal cell proliferation.

    摘要翻译： 公开了N-（6-（4-氯苯氧基）己基）-N'-氰基-N“ - （4-吡啶基）胍或其溶剂化物的多晶型物I-VI，其制备方法和用途 作为生物活性成分。 多晶型物可用于治疗由异常细胞增殖引起的癌症和疾病或病症。

    Use of 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives as tumor necrosis factor inhibitor
    4.
    发明授权
    Use of 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives as tumor necrosis factor inhibitor 有权
    使用5H-硫代（3,4-c）吡咯-4,6-二酮衍生物作为肿瘤坏死因子抑制剂

    公开(公告)号：US08524742B2

    公开(公告)日：2013-09-03

    申请号：US13468031

    申请日：2012-05-09

    申请人： Hesheng Zhang

    发明人： Hesheng Zhang

    IPC分类号： A61K31/407

    CPC分类号： C07D495/04

    摘要： A method of treating or curing a disease caused by or associated with elevated levels of TNF in a patient including administering to the patient 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives.

    摘要翻译： 治疗或治愈由患者的TNF升高引起或与TNF水平升高相关的疾病的方法，包括给予患者5H-硫炔（3,4-c）吡咯-4,6-二酮衍生物。

    Pyrroline derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof
    5.
    发明授权
    Pyrroline derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof 有权
    针对细胞释放肿瘤坏死因子的吡咯啉衍生物，其制备方法和用途

    公开(公告)号：US08466191B2

    公开(公告)日：2013-06-18

    申请号：US12514672

    申请日：2007-10-16

    申请人： Hesheng Zhang

    发明人： Hesheng Zhang

    IPC分类号： A61K31/407 ,  C07D495/06

    CPC分类号： C07D487/04 ,  C07D495/04

    摘要： Compounds represented by Formula (I) or Formula (II) against cell releasing TNFα, their pharmaceutically acceptable salts or hydrates and preparation methods and uses thereof, in which A and B represent CH2, CO, SO, or SO2; D represents S, NH, or NC1-6 alkyl; R1 represents H, or one or two same or different radical(s) selected from the group consisting of F, Cl, Br, C1-4 alkyl, OH, OC1-4 alkyl, NO2, NHC(O)C1-4 alkyl, NH2, NH(C1-4 alkyl), or N(C1-4 alkyl)2.

    摘要翻译： 由式（I）或式（II）表示的抗细胞释放TNFal的化合物及其药学上可接受的盐或水合物及其制备方法和用途，其中A和B表示CH 2，CO，SO或SO 2; D表示S，NH或NC1-6烷基; R 1表示H或选自F，Cl，Br，C 1-4烷基，OH，OC 1-4烷基，NO 2，NHC（O）C 1-4烷基， NH 2，NH（C 1-4烷基）或N（C 1-4烷基）2。

    Quinazoline and quinoline derivatives as irreversible protein tyrosine kinase inhibitors
    6.
    发明授权
    Quinazoline and quinoline derivatives as irreversible protein tyrosine kinase inhibitors 有权
    喹唑啉和喹啉衍生物作为不可逆蛋白酪氨酸激酶抑制剂

    公开(公告)号：US07754729B2

    公开(公告)日：2010-07-13

    申请号：US12342104

    申请日：2008-12-23

    申请人： Hesheng Zhang

    发明人： Hesheng Zhang

    IPC分类号： A61K31/517

    CPC分类号： C07D239/94 ,  C07D401/12 ,  C07D401/14

    摘要： A compound of formula (I), a pharmaceutically acceptable salt, or hydrate thereof, and a method of preparing the same. A method of treating or preventing a physiological disorder caused by abnormal protein tyrosine kinase activity in a mammal comprising administering to said mammal a pharmaceutical composition comprising a compound of formula (I).

    摘要翻译： 式（I）的化合物，其药学上可接受的盐或水合物及其制备方法。 一种治疗或预​​防由哺乳动物异常蛋白酪氨酸激酶活性引起的生理障碍的方法，包括向所述哺乳动物施用包含式（I）化合物的药物组合物。

    Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors
    9.
    发明授权
    Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors 有权
    哌啶-2,6-二酮衍生物及其作为肿瘤坏死因子抑制剂的用途

    公开(公告)号：US08637545B2

    公开(公告)日：2014-01-28

    申请号：US11868502

    申请日：2007-10-07

    申请人： Hesheng Zhang

    发明人： Hesheng Zhang

    IPC分类号： A61K31/454 ,  C07D403/14

    CPC分类号： A61K31/454 ,  A61K31/445 ,  C07D401/04 ,  C07D401/14 ,  Y02A50/411

    摘要： This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives, and their application as active pharmaceutical ingredient as inhibitors of TNFα releasing in cells, the derivative of piperidine-2,6-dione being of the general formula (I): wherein n represents 1, 2, 3, 4, 5 or 6; R1 represents from one to four of the same or different substituents selected from F, Cl, Br, C1-4 alkyl, OH, OC1-4 alkyl, NO2, NHC(O)C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2; R2 represents OR3, NR3R4, N(R3)COR4, O2CR5; R3 and R4 represent independently and at each occurrence H or C1-4 alkyl; R5 represents CHR6NR7R8, CHR6NR9C(O)CHR10NR7R8, a heterocycle W or CHR6NR9C(O)W; R6, R9, R10 represent independently and at each occurrence H, or C1-4 alkyl; R7 and R8 represent independently and at each occurrence H, C1-4 alkyl, or R7 and R8 taken together represent 1,3-propylene, 1,4-butylene, 1,5-pentylene, or 1,6-hexylene; W represents four-membered, five-membered, six-membered, seven-membered, or eight-membered saturated or unsaturated heterocycle.

    摘要翻译： 本发明涉及哌啶-2,6-二酮或其有机或无机盐的衍生物，这些衍生物的合成方法及其作为活性药物成分作为细胞中TNFα释放抑制剂的应用，哌啶衍生物 -2,6-二酮，其通式（I）：其中n表示1,2,3,4,5或6; R 1表示1-4个相同或不同的选自F，Cl，Br，C 1-4烷基，OH，OC 1-4烷基，NO 2，NHC（O）C 1-4烷基，NH 2，NH（C 1-4） 烷基），N（C 1-4烷基）2; R 2表示OR 3，NR 3 R 4，N（R 3）COR 4，O 2 CR 5; R 3和R 4独立地表示，并且在每次出现时，H或C 1-4烷基; R5表示CHR6NR7R8，CHR6NR9C（O）CHR10NR7R8，杂环W或CHR6NR9C（O）W; R 6，R 9，R 10独立地表示，并且在每次出现时均为H或C 1-4烷基; R 7和R 8分别独立地表示，H，C 1-4烷基或R 7和R 8一起代表1,3-丙烯，1,4-亚丁基，1,5-亚戊基或1,6-亚己基; W代表四元，五元，六元，七元或八元饱和或不饱和杂环。