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    Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
    2.
    发明授权
    Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions 失效
    用于预防或治疗坏死性骨质状况的含锶化合物

    公开(公告)号：US08609616B2

    公开(公告)日：2013-12-17

    申请号：US13182798

    申请日：2011-07-14

    申请人： Christian Hansen ,  Henrik Nilsson ,  Stephan Christgau ,  Henry G Bone, III

    发明人： Christian Hansen ,  Henrik Nilsson ,  Stephan Christgau ,  Henry G Bone, III

    IPC分类号： A61P19/08

    CPC分类号： A61K33/24 ,  A61K31/28 ,  A61K31/56 ,  A61K31/57 ,  A61K31/663 ,  A61K45/06 ,  A61K2300/00

    摘要： A method for the treatment and/or prophylaxis of an osteonecrotic bone disease in a mammal in need thereof, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis, Legg-Calve-Perthes disease and femoral head necrosis, the method comprising administering an effective dose of a strontium-containing compound (a) to the mammal. A method for the treatment and/or prophylaxis of an osteonecrotic bone disease, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis and femoral head necrosis, in a mammal who is to be or is treated with a therapeutic agent (b) known to or suspected of inducing apoptosis and/or necrosis of bone cells, the method comprising administering a strontium-containing compound (a) in combination with (b).

    摘要翻译： 用于治疗和/或预防有需要的哺乳动物中的骨坏死性骨病的方法，例如特发性或继发性骨坏死，无血管性骨坏死，糖皮质激素诱导的骨缺血/骨坏死，Legg-Calve-Perthes疾病和股骨 头坏死，所述方法包括向哺乳动物施用有效剂量的含锶化合物（a）。 用于治疗和/或预防将要或被治疗的哺乳动物中的骨坏死性骨病，例如特发性或继发性骨坏死，无血管性骨坏死，糖皮质激素诱导的骨缺血/骨坏死和股骨头坏死的方法 具有已知或怀疑诱导骨细胞凋亡和/或坏死的治疗剂（b），该方法包括与（b）组合施用含锶化合物（a）。

    Uses of secretagogues like ghrelin in cancer cachexia and for stimulating appetite
    6.
    发明申请
    Uses of secretagogues like ghrelin in cancer cachexia and for stimulating appetite 审中-公开
    使用促分泌素如生长素释放肽在癌症恶病质和刺激食欲

    公开(公告)号：US20070037751A1

    公开(公告)日：2007-02-15

    申请号：US10567406

    申请日：2004-08-06

    申请人： Birgitte Lange ,  Christian Hansen ,  Henrik Nilsson

    发明人： Birgitte Lange ,  Christian Hansen ,  Henrik Nilsson

    IPC分类号： A61K38/08 ,  A61K38/05 ,  A61K38/06

    CPC分类号： C07K14/575 ,  A61K38/00

    摘要： The present invention relates, in one aspect, to the use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. In another aspect, the present invention relates to the use of a ghrelin-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. In a further aspect, the present invention relates to the use of a ghrelin-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. Furthermore, the present invention relates to a number of new ghrelin-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin-like compounds.

    摘要翻译： 本发明在一个方面涉及促分泌素化合物在制备用于预防或治疗需要这种治疗的个体中的癌症恶病质的药物中的用途。 另一方面，本发明涉及生长素释放肽样化合物在制备用于预防或治疗个体中恶病质的药物中的用途，其通过向个体施用皮下剂量的所述药物。 在另一方面，本发明涉及生长素释放肽样化合物或其药学上可接受的盐在制备用于通过向个体施用所述药物的皮下剂量来刺激个体中的食欲的药物中的用途。 此外，本发明涉及许多新的生长素释放肽样化合物及其用途，以及包含新的生长素释放肽样化合物的药物组合物和医药包装。

    Computer-Based Method And System For Imaging-Based Dynamic Function Evaluation Of An Organ
    8.
    发明申请
    Computer-Based Method And System For Imaging-Based Dynamic Function Evaluation Of An Organ 审中-公开
    基于计算机的方法和系统，用于基于成像的一个器官的动态功能评估

    公开(公告)号：US20110098556A1

    公开(公告)日：2011-04-28

    申请号：US12922152

    申请日：2009-03-11

    申请人： Lennart Blomqvist ,  Anders Nordell ,  Eduard Jonas ,  Henrik Nilsson

    发明人： Lennart Blomqvist ,  Anders Nordell ,  Eduard Jonas ,  Henrik Nilsson

    IPC分类号： A61B5/055

    CPC分类号： G01R33/56366 ,  A61B5/42 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/56308 ,  G16H50/20

    摘要： A computer-based method of determining a functional assessment of at least one organ having secretional or excretional functions, such as a liver or kidneys, of a human is disclosed. The method comprises processing a four-dimensional (4D) image data set of said human comprising data for an assessment of said organ function, wherein said 4D image data is acquired by an image modality; and wherein said processing said 4D image data comprises performing a deconvolutional analysis (DA) comprising a matrix inversion using singular value decomposition (SVD) based on said 4D image data.

    摘要翻译： 公开了一种基于计算机的方法，其确定至少一个具有分泌或排泄功能的器官（例如肝或肾）的功能评估。 该方法包括处理所述人的四维（4D）图像数据集合，其包括用于评估所述器官功能的数据，其中所述4D图像数据由图像模态获取; 并且其中所述处理所述4D图像数据包括基于所述4D图像数据执行包括使用奇异值分解（SVD）的矩阵求逆的解卷积分析（DA）。

    USE OF A GLP-1 MOLECULE FOR TREATMENT OF BILIARY DYSKINESIA AND/OR BILIARY PAIN/DISCOMFORT
    9.
    发明申请
    USE OF A GLP-1 MOLECULE FOR TREATMENT OF BILIARY DYSKINESIA AND/OR BILIARY PAIN/DISCOMFORT 审中-公开
    用于治疗胆汁淤积症和/或胆汁淤积/分泌的GLP-1分子的使用

    公开(公告)号：US20090181887A1

    公开(公告)日：2009-07-16

    申请号：US12066178

    申请日：2006-09-06

    申请人： Christian Hansen ,  Henrik Nilsson ,  Hans T. Schambye ,  Tina Geritz Nielsen

    发明人： Christian Hansen ,  Henrik Nilsson ,  Hans T. Schambye ,  Tina Geritz Nielsen

    IPC分类号： A61K38/22 ,  A61P25/00 ,  G01N33/566

    CPC分类号： A61K38/26 ,  G01N2333/605 ,  G01N2500/02 ,  G01N2800/08 ,  Y02A50/49

    摘要： The present invention relates to molecules, compositions and methods suitable for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree. The peptide hormone glucagon-like peptide-1 (GLP-1) has both anti-secretory effects and smooth muscle relaxatory properties in the gastrointestinal tract. GLP-1 exists in several forms, where the natural occurring GLP-1 molecules are GLP-1 (1-37), GLP-1 (7-37), and the amidated versions GLP-1 (1-36)amide, GLP-1 (7-36)amide. Other molecules capable of binding to and activating the GLP-1 receptor is herein included in the tern GLP-1 molecules. GLP-1 molecules may be naturally occurring or homologues of GLP-1 having one or more amino acid substitutions or modifications. The GLP-1 molecules are used for the manufacture of a medicament for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree.

    摘要翻译： 本发明涉及适用于治疗或预防来自胆道树的胆汁运动障碍和/或疼痛和/或不适的分子，组合物和方法。 肽激素胰高血糖素样肽-1（GLP-1）在胃肠道中具有抗分泌作用和平滑肌松弛性质。 GLP-1以几种形式存在，其中天然存在的GLP-1分子是GLP-1（1-37），GLP-1（7-37）和酰胺化型GLP-1（1-36）酰胺，GLP -1（7-36）酰胺。 在GLP-1分子中包括能够结合并激活GLP-1受体的其它分子。 GLP-1分子可以是具有一个或多个氨基酸取代或修饰的GLP-1的天然存在或同源物。 GLP-1分子用于制造用于治疗或预防胆汁运动障碍和/或来自胆道树的疼痛和/或不适的药物。