公开(公告)号：US20080264865A1

公开(公告)日：2008-10-30

申请号：US12055159

申请日：2008-03-25

Applicant: Heath H. Herman

Inventor： Heath H. Herman

IPC: B01D15/08

CPC classification number: B01D15/18 ,  B01D15/08 ,  G01N30/6065 ,  G01N2030/381 ,  G01N2030/386

Abstract: The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.

Abstract translation: 本发明涉及用于分离和分离靶分子的方法和组合物。 特别地，本发明包括诸如CCD的装置，其包含不需要支撑结构的颗粒。 在CCD中使用色谱分离技术，包括但不限于离子交换，大小分离，亲和层析，离子排斥，配体交换，反相和正相分离。 方法还包括低，中，高压液相色谱。 这些方法可用于分析，半制备过程，初步澄清，制备过滤和工艺规模应用。

公开(公告)号：US4906668A

公开(公告)日：1990-03-06

申请号：US107402

申请日：1987-10-13

Applicant: Sheldon W. May ,  Heath H. Herman ,  Steven F. Roberts

Inventor： Sheldon W. May ,  Heath H. Herman ,  Steven F. Roberts

IPC: A61K31/095 ,  C07C391/02

CPC classification number: A61K31/095 ,  C07C391/02

Abstract: The preparation of aminoalkyl phenyl selenides and pharmaceutically acceptable salts thereof is disclosed which are useful for the treatment of hypertension and related vascular diseases and the treatment of nervous system dysfunctions.

Abstract translation: 公开了氨基烷基苯基硒化物及其药学上可接受的盐的制备，其可用于治疗高血压和相关的血管疾病和治疗神经系统功能障碍。

公开(公告)号：US06660509B1

公开(公告)日：2003-12-09

申请号：US09316566

申请日：1999-05-21

Applicant: Heath H. Herman ,  Tod M. Herman ,  Arlan K. Andrews, Sr.

Inventor： Heath H. Herman ,  Tod M. Herman ,  Arlan K. Andrews, Sr.

IPC: C12N1100

CPC classification number: C12M33/12 ,  C12M23/58 ,  C12M33/10

Abstract: Abstract of the Invention The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support complexes that add to the resultant vector forces. One embodiment of the apparatus comprises a cruciform design. Commercial applications of the apparatus include efficient isolation of metals from ores and removal of gases.

Abstract translation: 发明概述本发明包括通过对抗力而使活细胞或亚细胞生物催化剂固定化的新型培养方法和装置。 固定的细胞或生物催化剂可以连接到支持复合物，这增加了合成的载体力。 该装置的一个实施例包括十字形设计。 该设备的商业应用包括从矿石中有效地分离金属和除去气体。

公开(公告)号：US5622819A

公开(公告)日：1997-04-22

申请号：US412289

申请日：1995-03-28

Applicant: Heath H. Herman

Inventor： Heath H. Herman

IPC: C12M1/10 ,  C12M1/00 ,  C12M1/40 ,  C12M3/00 ,  C12M3/02 ,  C12N1/00 ,  C12N5/06 ,  C12P1/00 ,  C12Q1/00 ,  C12Q1/02

CPC classification number: C12M33/10 ,  C12M23/58 ,  C12M33/12 ,  B04B2005/0471 ,  Y10S435/813

Abstract: The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of particles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.

Abstract translation: 本发明包括通过与离心力场和液体流场相反的方式固定活细胞或亚细胞生物催化剂的新型培养方法和装置。 固定的细胞或生物催化剂被排列成三维的颗粒阵列，其密度由颗粒尺寸，形状，固有密度以及通过选择诸如液体流速和角速度的参数的组合来确定。

公开(公告)号：US4722940A

公开(公告)日：1988-02-02

申请号：US816909

申请日：1986-01-08

Applicant: Sheldon W. May ,  Heath H. Herman ,  Steven F. Roberts

Inventor： Sheldon W. May ,  Heath H. Herman ,  Steven F. Roberts

IPC: A61K31/095 ,  C07C391/02

CPC classification number: A61K31/095 ,  C07C391/02

Abstract: The preparation of aminoalkyl phenyl selenides and pharmaceutically acceptable salts thereof is disclosed which are useful for the treatment of hypertension and related vascular diseases and the treatment of nervous system dysfunctions.

公开(公告)号：US4415591A

公开(公告)日：1983-11-15

申请号：US270247

申请日：1981-06-04

Applicant: Sheldon W. May ,  Robert S. Phillips ,  Heath H. Herman ,  Patricia W. Mueller

Inventor： Sheldon W. May ,  Robert S. Phillips ,  Heath H. Herman ,  Patricia W. Mueller

IPC: A61K31/13 ,  A61K31/10

CPC classification number: A61K31/13

Abstract: Hypertension in mammals can be treated by administering an effective amount of an aminoalkyl phenyl sulfide having the formula ##STR1## wherein (C.sub.n H.sub.2n)=a linear or branched alkyl chain of 10 carbons or less (n=1-10);R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5,=H, OH, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, F, Cl, Br, or I;R.sub.6 R.sub.7 =H, C.sub.1 -C.sub.4 -alkyl;and the pharmaceutically acceptable salts thereof. The hypotensive potential of the compounds may be evaluated by oxygenation with dopamine-beta-hydroxylase.

Abstract translation: 哺乳动物的高血压可以通过施用有效量的具有式（IMA）的氨基烷基苯基硫醚来治疗，其中（C n H 2n）=直链或支链烷基链为10个碳以下（n = 1-10）; R1，R2，R3，R4，R5，= H，OH，C1-C4-烷基，C1-C4-烷氧基，F，Cl，Br或I; R6 R7 = H，C1-C4-烷基; 及其药学上可接受的盐。 可以通过用多巴胺-β-羟化酶氧合来评估化合物的降血压潜力。

公开(公告)号：US06916652B2

公开(公告)日：2005-07-12

申请号：US10153161

申请日：2002-05-22

Applicant: Peter J. Petrecca ,  Heath H. Herman ,  Tod M. Herman ,  Robert A. Cuneo

Inventor： Peter J. Petrecca ,  Heath H. Herman ,  Tod M. Herman ,  Robert A. Cuneo

IPC: C12M1/10 ,  C12M3/04 ,  C12M1/36

CPC classification number: C12M27/06 ,  C12M21/18 ,  C12M23/34

Abstract: The invention comprises novel culture methods and devices in which biocatalysts are substantially immobilized contained, suspended and or incubated in a chamber. At least one injection element provides a fluid flow to a perimeter of the chamber and the fluid force of the fluids flowing into the chamber works with the centripetal force created by rotation of the device to suspend the cells within the chamber, promote cell growth and/or clean the fluid as it passes thru the suspended biocatalyst.

Abstract translation: 本发明包括新颖的培养方法和装置，其中生物催化剂被基本上固定化，悬浮和/或孵育在室中。 至少一个注射元件提供流向腔室周边的流体流动，并且流入腔室的流体的流体力利用装置的旋转产生的向心力作用，以将细胞悬浮在腔室内，促进细胞生长和/ 或者当流体通过悬浮的生物催化剂时清洁流体。

公开(公告)号：US06214617B1

公开(公告)日：2001-04-10

申请号：US09224645

申请日：1998-12-31

Applicant: Heath H. Herman

Inventor： Heath H. Herman

IPC: C12N500

CPC classification number: C12M35/04 ,  C12M23/34 ,  C12M23/58 ,  C12M41/00

Abstract: The present invention comprises a novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support complexes that add to the resultant vector forces.

Abstract translation: 本发明包括一种新的培养方法和装置，其中活细胞或亚细胞生物催化剂被力的固定化。 固定的细胞或生物催化剂可以连接到支持复合物，这增加了合成的载体力。

公开(公告)号：US5821116A

公开(公告)日：1998-10-13

申请号：US784718

申请日：1997-01-16

Applicant: Heath H. Herman

Inventor： Heath H. Herman

IPC: C12M1/10 ,  C12M1/00 ,  C12M1/40 ,  C12M3/00 ,  C12M3/02 ,  C12N1/00 ,  C12N5/06 ,  C12P1/00

CPC classification number: C12M33/10 ,  C12M23/58 ,  C12M33/12 ,  B04B2005/0471 ,  Y10S435/813

Abstract: The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of articles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.

公开(公告)号：US07347943B2

公开(公告)日：2008-03-25

申请号：US11214144

申请日：2005-08-29

Applicant: Heath H. Herman

Inventor： Heath H. Herman

IPC: B01D15/08

CPC classification number: B01D15/18 ,  B01D15/08 ,  G01N30/6065 ,  G01N2030/381 ,  G01N2030/386

Abstract: The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.

Abstract translation: 本发明涉及用于分离和分离靶分子的方法和组合物。 特别地，本发明包括诸如CCD的装置，其包含不需要支撑结构的颗粒。 在CCD中使用色谱分离技术，包括但不限于离子交换，大小分离，亲和层析，离子排斥，配体交换，反相和正相分离。 方法还包括低，中，高压液相色谱。 这些方法可用于分析，半制备过程，初步澄清，制备过滤和工艺规模应用。