公开(公告)号：US4860756A

公开(公告)日：1989-08-29

申请号：US89190

申请日：1987-08-25

Applicant: Harvey W. Ko ,  Lynn W. Hart ,  Joseph P. Skura

Inventor： Harvey W. Ko ,  Lynn W. Hart ,  Joseph P. Skura

IPC: A61B5/05 ,  A61B5/053 ,  G01V3/10

CPC classification number: A61B5/053 ,  G01V3/102

Abstract: An apparatus and method for non-invasive sensing of bone healing is disclosed. The apparatus and method uses an electromagnetic field to measure impedance changes at and about the bone fracture site during the healing process. The impedance change at the fracture site is a direct indication of the mechanical strength of the fracture site. A multi-coil sensor array is taught, which may be sutured to the patient's skin or mounted onto a plug that is inserted through a window in the cast.

Abstract translation: 公开了一种用于骨愈合的非侵入式感测的装置和方法。 该装置和方法使用电磁场来测量愈合过程中骨折部位处和周围的阻抗变化。 骨折部位的阻抗变化直接指示骨折部位的机械强度。 教导了多线圈传感器阵列，其可以缝合到患者的皮肤上或者被安装到插入通过铸件中的窗口的塞子上。

公开(公告)号：US4850372A

公开(公告)日：1989-07-25

申请号：US89193

申请日：1987-08-25

Applicant: Harvey W. Ko ,  Joseph P. Skura

Inventor： Harvey W. Ko ,  Joseph P. Skura

IPC: A61B5/05 ,  A61B5/053 ,  A61B5/103

CPC classification number: A61B5/053 ,  A61B5/4504

Abstract: A method for noninvasively sensing bone mass loss associated with osteoporosis is disclosed. The method uses an electromagnetic field to measure impedance (or conductivity) changes in the bone. A decrease in conductivity is indicative of osteoporosis.

Abstract translation: 公开了一种用于非侵入性地感测与骨质疏松症相关的骨质量损失的方法。 该方法使用电磁场来测量骨骼中的阻抗（或电导率）变化。 电导率的降低表明骨质疏松症。

公开(公告)号：US4913152A

公开(公告)日：1990-04-03

申请号：US390495

申请日：1989-08-01

Applicant: Harvey W. Ko ,  Joseph P. Skura ,  Harry A. C. Eaton

Inventor： Harvey W. Ko ,  Joseph P. Skura ,  Harry A. C. Eaton

IPC: A61B5/04

CPC classification number: A61B5/04005

Abstract: An apparatus and method for the passive, non-invasive magnetoencephalographic (MEG) localization and tracking of sources of magnetic signals in the brain is disclosed. The apparatus and method uses a multi-axis magnetic gradiometer to detect the magnetic field, field gradient, and polarization emanating from neuronal sources in the brain under either normal or pathological conditions.

Abstract translation: 公开了一种用于脑内磁信号源的被动，非侵入式脑磁图（MEG）定位和跟踪的装置和方法。 该装置和方法使用多轴磁梯度计检测在正常或病理状态下脑内神经元源发出的磁场，场梯度和极化。

公开(公告)号：US4688580A

公开(公告)日：1987-08-25

申请号：US753824

申请日：1985-07-11

Applicant: Harvey W. Ko ,  Lynn W. Hart

Inventor： Harvey W. Ko ,  Lynn W. Hart

IPC: G01N27/72 ,  A61B5/04 ,  A61B5/05 ,  A61B5/053 ,  A61B5/103 ,  G01V3/10

CPC classification number: G01V3/102 ,  A61B5/053 ,  A61B5/4504

Abstract: An apparatus and method for non-invasive sensing of bone healing is disclosed. The apparatus and method uses an electromagnetic field to measure impedance changes at the bone fracture site during the healing process. The impedance change at the fracture site is a direct indication of the mechanical strength of the fracture site.

Abstract translation: 公开了一种用于骨愈合的非侵入式感测的装置和方法。 该装置和方法使用电磁场来测量愈合过程中骨折部位的阻抗变化。 断裂部位的阻抗变化直接指示骨折部位的机械强度。

公开(公告)号：US07283868B2

公开(公告)日：2007-10-16

申请号：US10204719

申请日：2001-04-05

Applicant: Harvey W. Ko ,  Dexter G. Smith

Inventor： Harvey W. Ko ,  Dexter G. Smith

IPC: A61B5/05

CPC classification number: A61B5/0522 ,  A61B5/05 ,  A61B5/053 ,  A61B5/0536 ,  A61B5/4381

Abstract: An electromagnetic bioimpedance measurement apparatus uses an alternating magnetic field to induce electrical eddy currents in biological tissue. The eddy currents produce secondary magnetic fields that have the effect of changing the mutual inductance between the tissue and the coil that applied to the initial magnetic field. The amplitude of the resultant voltage, as measured by the same coil or a different receiver coil, is proportional to the conductivity of the tissue. A simple, marginally stable oscillator circuit is used to generate the current into the coil. Nearfield holographic signal processing is then used for holographic image formation. Bioimpedance is used to distinguish between normal tissue and cancerous tissue, especially cancerous prostate tissue. An invasive embodiment includes driven needle electrodes that are inserted into the body segment to be tested. Noninvasive embodiments include single or multiple coils arranged on a probe shaft.

Abstract translation: 电磁生物阻抗测量装置使用交变磁场来诱导生物组织中的电涡流。 涡流产生二次磁场，其具有改变应用于初始磁场的组织和线圈之间的互感的作用。 由相同线圈或不同的接收器线圈测量的合成电压的幅度与组织的电导率成比例。 使用简单的，稍微稳定的振荡器电路来产生线圈中的电流。 然后将近场全息信号处理用于全息图像形成。 生物阻抗用于区分正常组织和癌组织，特别是癌前列腺组织。 侵入性实施例包括被插入被检体内段的驱动针电极。 非侵入性实施例包括布置在探针轴上的单个或多个线圈。

公开(公告)号：US11298055B2

公开(公告)日：2022-04-12

申请号：US17305787

申请日：2021-07-14

Applicant: Harvey W. Ko

Inventor： Harvey W. Ko

IPC: A61B5/145 ,  A61B5/01 ,  A61B5/00

Abstract: A noninvasive glucose monitoring device includes a drive-and-sense coil and an electronic oscillator with multiple circuits electrically connected to the coil. The drive-and-sense coil may be embedded in either a finger clip or a finger push button. The device measures bioimpedance with a magnetic field coil outside a user's finger. The coil measures blood and glucose electrical conductivity without penetrating the finger. No blood extraction is required. A noninvasive method of measuring glucose in-vivo includes placing the drive-and-sense coil next to a subject's finger and inducing magnetic fields in blood in the subject's finger. A change in mutual impedance between the drive-and-sense coil and the blood is measured at predetermined frequencies and glucose content is calculated from the change in mutual impedance according to a predetermined correlation for each frequency.

公开(公告)号：US09370309B2

公开(公告)日：2016-06-21

申请号：US13885746

申请日：2011-11-18

Applicant: Harvey W. Ko ,  Ibolja Cernak ,  Michael P. McLoughlin

Inventor： Harvey W. Ko ,  Ibolja Cernak ,  Michael P. McLoughlin

IPC: A61B5/04 ,  A61B5/00

CPC classification number: A61B5/04008 ,  A61B5/04009 ,  A61B5/6814 ,  A61B5/721 ,  A61B2562/0219

Abstract: A magnetoencephalogram (MEG) system is provided for use with a head. The MEG system includes a shell, and three three-axis gradiometers and a computing portion. Each three-axis gradiometer detects a magnetic field vector from a magnetic dipole in the head and generates a respective detected signal based on the respective magnetic field vector. Each three-axis gradiometer is disposed at a respective position of the shell. The computing portion determines a location of the magnetic dipole based on the first detected signal, the second detected signal and the third detected signal.

Abstract translation: 提供脑磁图（MEG）系统用于头部。 MEG系统包括壳体和三个三轴梯度计和计算部分。 每个三轴梯度计检测来自头部中的磁偶极子的磁场矢量，并且基于相应的磁场矢量产生相应的检测信号。 每个三轴梯度计设置在壳体的相应位置。 计算部分基于第一检测信号，第二检测信号和第三检测信号来确定磁偶极子的位置。

公开(公告)号：US20140005518A1

公开(公告)日：2014-01-02

申请号：US13885746

申请日：2011-11-18

Applicant: Harvey W. Ko ,  Ibolja Cernak ,  Michael P. McLoughlin

Inventor： Harvey W. Ko ,  Ibolja Cernak ,  Michael P. McLoughlin

IPC: A61B5/04

CPC classification number: A61B5/04008 ,  A61B5/04009 ,  A61B5/6814 ,  A61B5/721 ,  A61B2562/0219

Abstract: A magnetoencephalogram (MEG) system is provided for use with a head. The MEG system includes a shell, and three three-axis gradiometers and a computing portion. Each three-axis gradiometer detects a magnetic field vector from a magnetic dipole in the head and generates a respective detected signal based on the respective magnetic field vector. Each three-axis gradiometer is disposed at a respective position of the shell. The computing portion determines a location of the magnetic dipole based on the first detected signal, the second detected signal and the third detected signal.

Abstract translation: 提供脑磁图（MEG）系统用于头部。 MEG系统包括壳体和三个三轴梯度计和计算部分。 每个三轴梯度计检测来自头部中的磁偶极子的磁场矢量，并且基于相应的磁场矢量产生相应的检测信号。 每个三轴梯度计设置在壳体的相应位置。 计算部分基于第一检测信号，第二检测信号和第三检测信号来确定磁偶极子的位置。

公开(公告)号：US07126148B2

公开(公告)日：2006-10-24

申请号：US10621595

申请日：2003-07-17

Applicant: George M. Murray ,  Harvey W. Ko ,  Glen Southard

Inventor： George M. Murray ,  Harvey W. Ko ,  Glen Southard

IPC: G01V5/10

CPC classification number: G01T3/06 ,  Y10S250/90

Abstract: A system for detecting neutron radiation. A liquid cocktail mixture comprised of a neutron absorber and a scintillator is housed in a Teflon® tube having a mirror at one end of the tube and a windowed portal at the other end of the tube. Neutrons that penetrate the tube react with the neutron absorber producing ionization that excites a scintillator to produce photons. A photo-multiplier tube is coupled with the windowed portal for receiving photons and converting the photons to electrical signals. A processing device is coupled to the photo-multiplier output for receiving and analyzing the electrical signals so as to provide a measurement pertaining to the presence and relative strength of neutron radiation. The tube can be adapted to function as a portable survey instrument. Alternatively, the tube can be stretched to cover large apertured areas. In such implementations a wavelength shifter is employed to convert light emitted to another wavelength giving a multiplier effect necessary for long light guides.

Abstract translation: 一种用于检测中子辐射的系统。 由中子吸收剂和闪烁体组成的液体混合物混合物容纳在管的一端具有反射镜的Teflon管和管的另一端的窗口入口。 渗透管的中子与中子吸收剂反应产生电离，激发闪烁体产生光子。 光电倍增管与窗口门户耦合以接收光子并将光子转换成电信号。 处理装置耦合到光电倍增器输出端，用于接收和分析电信号，以提供与中子辐射的存在和相对强度有关的测量。 该管可适用于便携式测量仪器。 或者，管可以被拉伸以覆盖大的有孔区域。 在这种实现中，使用波长移位器将发射的光转换成另一波长，给出长光导所需的乘法器效应。

公开(公告)号：US06969605B2

公开(公告)日：2005-11-29

申请号：US09906243

申请日：2001-07-16

Applicant: Charles W. Anderson ,  C. Brent Bargeron ,  Richard C. Benson ,  Micah A. Carlson ,  Allan B. Fraser ,  John D. Groopman ,  Harvey W. Ko ,  David R. Kohler ,  Terry E. Phillips ,  Paul T. Strickland

Inventor： Charles W. Anderson ,  C. Brent Bargeron ,  Richard C. Benson ,  Micah A. Carlson ,  Allan B. Fraser ,  John D. Groopman ,  Harvey W. Ko ,  David R. Kohler ,  Terry E. Phillips ,  Paul T. Strickland

IPC: B01L3/00 ,  G01N1/02 ,  G01N1/40 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N30/02 ,  G01N33/543 ,  G01N33/58 ,  C12M3/00

CPC classification number: G01N1/40 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2400/0481 ,  G01N1/405 ,  G01N21/6428 ,  G01N21/645 ,  G01N30/02 ,  G01N33/54373 ,  G01N33/582 ,  G01N2001/022 ,  G01N2201/0221 ,  B01D15/3804

Abstract: A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined. The rinsing and elution fluids, and/or the affinity column can be placed in a module for easy insertion and removal from the sensor when depleted or when the sensor is to be used against a different analyte.

Abstract translation: 用于检测和量化多种分析物的手持式，独立的，自动的，低功率和快速的传感器平台。 可能含有未知量的分析物的样品溶液通过亲和柱，其包含分析物结合的抗体，从而提取分析物。 然后漂洗亲和柱以除去可能发荧光的任何其他化学物质。 然后用已知体积的洗脱液洗脱漂洗的亲和柱，使得分析物从抗体中释放并溶解在流体（洗脱剂）中。 然后将洗脱液置于荧光计的石英比色杯中。 悬浮在洗脱液中的分析物以与激发它的光源不同的波段发出荧光。 测量荧光的量并测定分析物的水平。 冲洗和洗脱流体和/或亲和柱可以放置在模块中，以便在耗尽时或当传感器用于抵抗不同分析物时容易地从传感器中插入和移除。