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公开(公告)号：US20060104899A1
公开(公告)日：2006-05-18
申请号：US11216033
申请日：2005-09-01
Applicant: Hans Hansen , Gary Griffiths , Shui-on Leung , William McBride , Zhengxing Qu
Inventor： Hans Hansen , Gary Griffiths , Shui-on Leung , William McBride , Zhengxing Qu
IPC: A61K51/00 , A61K39/395 , A61K49/16
CPC classification number: C07K16/468 , A61K47/6863 , A61K47/6899 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K16/18 , C07K16/30 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
Abstract: The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. The antigenic linker is conjugated to one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them.
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公开(公告)号：US20050100543A1
公开(公告)日：2005-05-12
申请号：US10882151
申请日：2004-07-01
Applicant: Hans Hansen , William McBride , Zhengxing Qu
Inventor： Hans Hansen , William McBride , Zhengxing Qu
IPC: A61K20060101 , A61K39/395 , A61K47/48 , A61K51/08 , A61K51/10 , C07K16/28 , C07K16/30 , C07K16/44 , C12N9/00
CPC classification number: C07K16/2887 , A61K47/6897 , A61K51/1027 , A61K51/1048 , A61K51/109 , A61K2039/505 , B82Y5/00 , C07K16/3007 , C07K2317/31 , C07K2317/622 , C07K2319/00 , C07K2319/01
Abstract: Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targetable construct with two or more bi-specific antibodies. The targetable constructs and targetable complexes of the invention are incorporated into biosensors, kits and pharmaceutical compositions, and are used in a variety of therapeutic and other methods.
Abstract translation: 本文提供作为双特异性抗体的多价载体的可靶向构建体，即可靶向构建体的每个分子可以用作两种或更多种双特异性抗体的载体。 还提供了通过可靶向构建体与两种或更多种双特异性抗体缔合形成的可靶向复合物。 将本发明的可靶向构建体和可靶向复合物掺入生物传感器，试剂盒和药物组合物中，并且以多种治疗和其它方法使用。
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公开(公告)号：US20060034759A1
公开(公告)日：2006-02-16
申请号：US11198846
申请日：2005-08-08
Applicant: David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Qu
Inventor： David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Qu
CPC classification number: A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
Abstract: The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
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公开(公告)号：US20050261170A1
公开(公告)日：2005-11-24
申请号：US11040114
申请日：2005-01-24
Applicant: Hans Hansen , William McBride , David Goldenberg , Edmund Rossi , Chien-Hsing Chang
Inventor： Hans Hansen , William McBride , David Goldenberg , Edmund Rossi , Chien-Hsing Chang
CPC classification number: C12N9/22 , A61K33/24 , A61K38/00 , A61K38/19 , A61K45/06 , A61K47/551 , C07K14/705 , Y02A50/401 , Y02A50/411 , Y02A50/473 , Y02A50/478 , A61K2300/00
Abstract: Disclosed are conjugates and complexes that include a folate receptor ligand and one or more therapeutic molecules, such as onconase or a variant thereof such as rapLR1. The conjugates and complexes may be useful as primary therapeutic agents, which may be administered with additional therapeutic or diagnostic agents. Also disclosed are kits that include the conjugates and complexes.
Abstract translation: 公开了包含叶酸受体配体和一种或多种治疗分子（例如onconase或其变体）如rapLR1的缀合物和复合物。 缀合物和复合物可用作主要治疗剂，其可以与另外的治疗剂或诊断剂一起施用。 还公开了包含缀合物和复合物的试剂盒。
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5.发明申请Drug pre-targeting by means of bi-specific antibodies and hapten constructs comprising a carrier peptide and the active agent(s) 审中-公开通过双特异性抗体和包含载体肽和活性剂的半抗原构建体的药物预靶向，公开(公告)号：US20060140858A1
公开(公告)日：2006-06-29
申请号：US10514632
申请日：2003-05-16
Applicant: David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Gu
Inventor： David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Gu
CPC classification number: A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
Abstract: The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds the targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the targetable constructs and bi-specific antibodies or antibody fragments, as well as methods for using them.
Abstract translation: 本发明涉及可靶向的构建体，其可以由具有特异性结合靶组织的至少一个臂的双特异性抗体或抗体片段和至少一个特异性结合可靶向构建体的其它臂结合。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生可靶向构建体和双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20050002945A1
公开(公告)日：2005-01-06
申请号：US10776470
申请日：2004-02-11
Applicant: William McBride , David Goldenberg , Carl Noren , Hans Hansen
Inventor： William McBride , David Goldenberg , Carl Noren , Hans Hansen
IPC: A61K47/48 , A61K51/04 , A61K51/08 , A61K51/10 , C07K7/06 , C07K16/18 , C07K16/30 , C07K16/44 , C07K16/46 , A61K39/00
CPC classification number: A61K51/0497 , A61K47/665 , A61K51/04 , A61K51/0455 , A61K51/048 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/06078 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
Abstract: Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
Abstract translation: 公开了包含两个或多个通过间隔物或载体缀合的半抗原的化合物。 半抗原可以包括二亚乙基三胺五乙酸（DTPA），组氨酰胺 - 琥珀酰 - 谷氨酰胺（HSG）或DTPA和HSG的组合。 化合物还包括效应分子，其可以与一个或多个半抗原，间隔物/载体或两者结合。 效应分子可以通过多个键连接，包括酯键，亚氨基键，氨基键，硫键，硫代缩氨基脲键，缩氨基脲键，肟键，醚键或这些键的组合。 还公开了合成化合物的化合物和/或前体的方法。
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公开(公告)号：US20050136001A1
公开(公告)日：2005-06-23
申请号：US10901441
申请日：2004-07-29
Applicant: William McBride , David Goldenberg
Inventor： William McBride , David Goldenberg
IPC: A61K47/48 , A61K49/04 , A61K51/04 , A61K51/08 , C07H3/00 , C07K16/30 , C07K16/44 , A61K51/00 , C07K16/46
CPC classification number: C07H3/00 , A61K47/64 , A61K47/6879 , A61K47/6897 , A61K49/0433 , A61K49/085 , A61K49/14 , A61K51/0491 , A61K51/088 , B82Y5/00 , C07K16/3007 , C07K16/44 , C07K2317/55
Abstract: Disclosed are novel conjugates that include fluorinated carbohydrate molecules and methods for synthesizing the conjugates. The fluorinated carbohydrate molecule may include a radioisotope. The method of synthesizing the conjugate is useful for labeling selected molecules, and the conjugates may be useful in diagnostic or therapeutic methods. Particularly, the conjugates may be useful in diagnostic or therapeutic kits.
Abstract translation: 公开了包括氟化碳水化合物分子的新型缀合物和用于合成缀合物的方法。 氟化碳水化合物分子可以包括放射性同位素。 合成缀合物的方法可用于标记所选择的分子，并且缀合物可用于诊断或治疗方法。 特别地，缀合物可用于诊断或治疗试剂盒。
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公开(公告)号：US5932189A
公开(公告)日：1999-08-03
申请号：US282980
申请日：1994-07-29
Applicant: Richard T. Dean , William McBride , John Lister-James
Inventor： Richard T. Dean , William McBride , John Lister-James
IPC: A61K38/04 , A61K38/00 , A61K51/00 , A61K51/08 , A61P35/00 , C07K7/50 , C07K7/64 , C07K14/655 , A61M36/14
CPC classification number: C07K14/6555 , A61K51/08 , A61K51/083 , A61K38/00
Abstract: This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, and radiodiagnostic reagents and peptides. Specifically, the invention relates to cyclic peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods for using such peptides for radiodiagnostic and radiotherapeutic purposes.
Abstract translation: 本发明涉及治疗试剂和肽，包括放射治疗试剂和肽，以及放射诊断试剂和肽。 具体地，本发明涉及生长抑素的环肽衍生物和类似物以及用放射性同位素放射性标记的这些肽的实施方案，以及使用这些肽用于放射诊断和放射治疗目的的方法。
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公开(公告)号：US5830856A
公开(公告)日：1998-11-03
申请号：US253317
申请日：1994-06-03
Applicant: Richard T. Dean , John Lister-James , Edgar R. Civitello , William McBride
Inventor： Richard T. Dean , John Lister-James , Edgar R. Civitello , William McBride
CPC classification number: A61K51/088 , A61K51/082 , A61K2123/00
Abstract: This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.
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公开(公告)号：USD285027S
公开(公告)日：1986-08-12
申请号：US573979
申请日：1984-01-25
Applicant: William McBride
Designer： William McBride
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