公开(公告)号：US12295771B2

公开(公告)日：2025-05-13

申请号：US17910311

申请日：2021-03-22

Applicant: HOLOGIC, INC.

Inventor： Baorui Ren ,  Kenneth Defreitas ,  Alan Rego ,  Christopher Ruth ,  Andrew P. Smith ,  Zhenxue Jing ,  Jay A. Stein

IPC: A61B6/50 ,  A61B6/00 ,  A61B6/02 ,  A61B6/04 ,  A61B6/46 ,  A61B90/00

Abstract: A method of imaging a breast compressed with a foam paddle includes emitting an x-ray energy from an x-ray source towards the breast and the foam paddle having a plurality of upper markers and a plurality of lower markers, wherein the plurality of lower markers are movable relative to the upper markers. The x-ray energy is detected at a detector disposed opposite the breast from the x-ray source. An image of the compressed breast is generated based on the detected x-ray energy. At least one of the plurality of upper markers and at least one of the plurality of lower markers is identified in the image. A thickness of the compressed breast at a plurality of thickness locations is determined, wherein each of the plurality of thickness locations corresponds to at least one of the plurality of lower markers.

公开(公告)号：US12239471B2

公开(公告)日：2025-03-04

申请号：US17843417

申请日：2022-06-17

Applicant: Hologic, Inc.

Inventor： Andrew P. Smith ,  Jay A. Stein ,  Zhenxue Jing ,  Baorui Ren ,  Loren Niklason ,  Christopher Ruth ,  Ian Shaw

IPC: A61B6/02 ,  A61B6/00 ,  A61B6/40 ,  A61B6/46 ,  A61B6/50

Abstract: Systems and methods for x-ray imaging a patient's breast in combinations of dual-energy, single-energy, mammography and tomosynthesis modes that facilitate screening for and diagnosis of breast abnormalities, particularly breast abnormalities characterized by abnormal vascularity.

公开(公告)号：US12121384B2

公开(公告)日：2024-10-22

申请号：US17910681

申请日：2021-03-30

Applicant: HOLOGIC, INC.

Inventor： Filip Nikolas Bundra ,  Christine Janssen ,  Zhenxue Jing ,  Tarpit Patel ,  Thomas Deyoung

IPC: A61B6/06 ,  A61B6/04 ,  A61B6/40 ,  A61B6/50 ,  A61B10/02 ,  G21K1/02

CPC classification number: A61B6/502 ,  A61B6/0414 ,  A61B6/06 ,  A61B6/4035 ,  A61B10/0283 ,  G21K1/025

Abstract: An x-ray breast imaging system includes a breast support platform including an x-ray receptor, and an x-ray tube head. The x-ray tube head includes an x-ray source configured to emit an x-ray beam in a direction towards the x-ray receptor, and a collimator. A filter assembly including a plurality of filter slots selectively positionable adjacent to the collimator, and a specimen imaging filter disposed within a slot of the plurality of filter slots. The specimen imaging filter includes at least one aperture defined therein. The specimen imaging filter also blocks a portion of the emitted x-ray beam so that the at least one aperture defines a path of the emitted x-ray beam towards the x-ray receptor.

公开(公告)号：US11426132B2

公开(公告)日：2022-08-30

申请号：US16981934

申请日：2019-05-24

Applicant: HOLOGIC, INC.

Inventor： Kenneth F. Defreitas ,  Alan Rego ,  Richard Gladwin Edwards ,  Christine Janssen ,  Zhenxue Jing ,  Jay A. Stein ,  Diane M. Conlin ,  Timothy N. Wells ,  Cornell Lee Williams

IPC: A61B6/04 ,  A61B6/00 ,  A61B6/02 ,  A61B6/03

Abstract: While performing a tomosynthesis procedure, the breast of a patient is compressed between two compression elements to create an imaging condition. Foam is secured to the rigid substrate of a one of the compression elements. The patient's chest wall is aligned with the leading edge surface of the foam. The inner side of the breast is disposed proximate the lateral edge surface of the foam and the outer side of the breast is disposed proximate the outer lateral edge surface of the foam. A mid-plane is disposed between the inner and outer lateral edge surfaces of the foam. An interface connects a leading edge surface of the foam and compressive surfaces. A portion of the leading edge surface which is aligned with the mid-plane is incompletely compressed.

公开(公告)号：US20210204894A1

公开(公告)日：2021-07-08

申请号：US17174708

申请日：2021-02-12

Applicant: Hologic, Inc.

Inventor： Baorui Ren ,  Andrew P. Smith ,  Zhenxue Jing ,  Jay Stein ,  Kenneth F. Defreitas

IPC: A61B6/00 ,  A61B6/04

Abstract: A method and an apparatus for estimating a geometric thickness of a breast in mammography/tomosynthesis or in other x-ray procedures, by imaging markers that are in the path of x-rays passing through the imaged object. The markings can be selected to be visible or to be invisible when the composite markings/breast image is viewed in clinical settings. If desired, the contribution of the markers to the image can be removed through further processing. The resulting information can be used determining the geometric thickness of the body being x-rayed and thus setting imaging parameters that are thickness-related, and for other purposes. The method and apparatus also have application in other types of x-ray imaging.

公开(公告)号：US09668711B2

公开(公告)日：2017-06-06

申请号：US15027650

申请日：2014-10-09

Applicant: Andrew Paul Smith ,  Jay Stein ,  Kenneth Defreitas ,  Ian Shaw ,  HOLOGIC, INC

Inventor： Andrew P. Smith ,  Jay A. Stein ,  Ken Defreitas ,  Ian Shaw ,  Zhenxue Jing ,  Loren Niklason ,  Baorui Ren ,  Christopher Ruth

IPC: A61B6/04 ,  A61B6/00 ,  G06T11/00 ,  A61B6/02 ,  A61B6/10

CPC classification number: A61B6/502 ,  A61B6/025 ,  A61B6/04 ,  A61B6/0414 ,  A61B6/102 ,  A61B6/107 ,  A61B6/4291 ,  A61B6/4435 ,  A61B6/466 ,  A61B6/5205 ,  A61B6/5223 ,  A61B6/54 ,  G06T11/005 ,  G06T11/006 ,  G06T2211/436

Abstract: Systems and methods for breast x-ray tomosynthesis that enhance spatial resolution in the direction in which the breast is flattened for examination. In addition to x-ray data acquisition of 2D projection tomosynthesis images ETp1 over a shorter source trajectory similar to known breast tomosynthesis, supplemental 2D images ETp2 are taken over a longer source trajectory and the two sets of projection images are processed into breast slice images ETr that exhibit enhanced spatial resolution, including in the thickness direction of the breast. Additional features include breast CT of an upright patient's flattened breast, multi-mode tomosynthesis, and shielding the patient from moving equipment.

公开(公告)号：US08873716B2

公开(公告)日：2014-10-28

申请号：US13905264

申请日：2013-05-30

Applicant: Hologic, Inc.

Inventor： Baorui Ren ,  Jay Stein ,  Zhenxue Jing ,  Andrew Smith

IPC: G21K1/08 ,  H01J35/30 ,  G01N23/083 ,  A61B6/02 ,  H05G1/52 ,  H01J35/14 ,  A61B6/00 ,  A61B6/03

CPC classification number: A61B6/4021 ,  A61B6/025 ,  A61B6/032 ,  A61B6/502 ,  H01J35/14 ,  H05G1/52

Abstract: An x-ray tube is described that includes components for increasing x-ray image clarity in the presence of a moving x-ray source by modifying focal spot characteristics, including focal spot size and focal spot position. In a first arrangement a static focal spot is moved in a direction contrary to the movement of the x-ray source so that an effective focal spot position is essentially fixed in space relative to one of the imaged object and/or detector during a tomosynthesis exposure. In a second arrangement, the size of the static focal spot is increased, and the resulting increase in tube current reduces the exposure time and concomitant blur effect. The methods may be used alone or in combination; for example an x-ray tube with a larger, moveable static focal spot will result in a system that fully utilizes the x-ray tube generator, provides a high quality image with reduced blur and, due to the decrease in exposure time, may scan the patient more quickly.

Abstract translation: 描述了一种X射线管，其包括用于通过改变焦点特性（包括焦点尺寸和焦斑位置）来增加在存在移动的X射线源的情况下增加x射线图像清晰度的部件。 在第一布置中，静止焦斑在与x射线源的运动相反的方向上移动，使得在断层合成曝光期间，有效焦点位置相对于成像对象和/或检测器之一基本上固定在空间中 。 在第二种布置中，静态焦点的尺寸增加，并且由此导致的管电流的增加降低了曝光时间并伴随着模糊效果。 这些方法可以单独使用或组合使用; 例如具有较大可移动静电焦点的X射线管将导致完全利用x射线管发生器的系统，提供具有减少的模糊的高质量图像，并且由于曝光时间的减少可能扫描 病人更快

公开(公告)号：US20140016737A1

公开(公告)日：2014-01-16

申请号：US13966606

申请日：2013-08-14

Applicant: Hologic, Inc.

Inventor： Baorui Ren ,  Andrew P. Smith ,  Thomas Farbizio ,  Zhenxue Jing ,  Jay Stein

IPC: A61B6/03

CPC classification number: A61B6/06 ,  A61B6/025 ,  A61B6/03 ,  A61B6/035 ,  A61B6/502 ,  G21K1/02 ,  G21K1/04

Abstract: In a tomosynthesis system a static focal spot is moved in a direction opposite to and generally synchronized with the directional movement of an x-ray source and X-ray collimator blades are moved during each exposure in synchronization with the shifting of the static focal spot. The synchronized movement of the static focal spot, x-ray tube and collimator blades helps keep the effective focal spot fixed in space relative to the breast, detector or both during the entire duration of the exposure and keeps the x-ray field on the detector and breast static. The shifting collimator blades follow an oscillating pattern over the multiple x-ray exposures of a tomosynthesis scan.

Abstract translation: 在断层合成系统中，静态焦点沿着与X射线源的定向运动相反并且大体上与X射线源的定向运动相同的方向移动，并且与静态焦点的移动同步地在每次曝光期间移动X射线准直器叶片。 静态焦点，X射线管和准直器刀片的同步运动有助于在曝光的整个持续时间内将有效焦斑保持在相对于乳房，检测器或两者的空间中，并将X射线场保持在检测器 和乳房静电。 移位准直器刀片遵循断层扫描合成扫描的多次X射线曝光的振荡模式。

公开(公告)号：US11850021B2

公开(公告)日：2023-12-26

申请号：US17847796

申请日：2022-06-23

Applicant: HOLOGIC, INC.

Inventor： Haili Chui ,  Zhenxue Jing

IPC: G06K9/62 ,  A61B5/00 ,  G06N3/04 ,  G06N3/08 ,  G06F18/40 ,  G06F18/214 ,  G06F18/21 ,  G06V10/774 ,  G06V10/82

CPC classification number: A61B5/0033 ,  G06F18/214 ,  G06F18/217 ,  G06F18/40 ,  G06N3/04 ,  G06N3/08 ,  G06V10/774 ,  G06V10/82 ,  G06V2201/03

Abstract: A method and system for creating a dynamic self-learning medical image network system, wherein the method includes receiving, from a first node initial user interaction data pertaining to one or more user interactions with the one or more initially obtained medical images; training a deep learning algorithm based at least in part on the initial user interaction data received from the node; and transmitting an instance of the trained deep learning algorithm to the first node and/or to one or more additional nodes, wherein at each respective node to which the instance of the trained deep learning algorithm is transmitted, the trained deep learning algorithm is applied to respective one or more subsequently obtained medical images in order to obtain a result.

公开(公告)号：US11751824B2

公开(公告)日：2023-09-12

申请号：US17814369

申请日：2022-07-22

Applicant: HOLOGIC, INC.

Inventor： Kenneth F. Defreitas ,  Alan Rego ,  Richard Gladwin Edwards ,  Zhenxue Jing ,  Jay A. Stein ,  Diane Conlin ,  Timothy N. Wells

IPC: A61B6/04 ,  A61B6/00 ,  A61B6/02 ,  A61B6/03

CPC classification number: A61B6/0414 ,  A61B6/0435 ,  A61B6/502 ,  A61B6/025 ,  A61B6/032

Abstract: While performing a tomosynthesis procedure, the breast of a patient is compressed between two compression elements to create an imaging condition. Foam is secured to the rigid substrate of a one of the compression elements. The patient's chest wall is aligned with the leading edge surface of the foam. The inner side of the breast is disposed proximate the lateral edge surface of the foam and the outer side of the breast is disposed proximate the outer lateral edge surface of the foam. A mid-plane is disposed between the inner and outer lateral edge surfaces of the foam. An interface connects a leading edge surface of the foam and compressive surfaces. A portion of the leading edge surface which is aligned with the mid-plane is incompletely compressed.