公开(公告)号：US09661212B2

公开(公告)日：2017-05-23

申请号：US14786574

申请日：2014-03-07

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Hideshi Oishi ,  Fumio Iwase ,  Masatoshi Okugawa

IPC: H04N5/225 ,  H04N5/232 ,  G02B7/34 ,  G02B7/36 ,  G02B21/24 ,  G02B21/36 ,  G02B21/18 ,  H04N5/235 ,  H04N5/247 ,  H04N5/262

CPC classification number: H04N5/23212 ,  G02B7/346 ,  G02B7/36 ,  G02B7/365 ,  G02B21/18 ,  G02B21/244 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  H04N5/2351 ,  H04N5/2353 ,  H04N5/247 ,  H04N5/2628

Abstract: In an image acquisition device, an optical path difference generating member can form an optical path length difference of a second light image without splitting light in a second optical path. This can suppress the quantity of light required for the second optical path to obtain information of the focal position, whereby a quantity of light can be secured for a first imaging device to capture an image. The image acquisition device synchronizes the movement of a predetermined part of a sample within a field of an objective lens with rolling readout such that each pixel column of a second imaging device is exposed to a light image of the predetermined part in the sample.

公开(公告)号：US20160080632A1

公开(公告)日：2016-03-17

申请号：US14786581

申请日：2014-04-21

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Fumio Iwase ,  Masatoshi Okugawa

IPC: H04N5/232 ,  G02B7/36 ,  G02B21/24 ,  G02B21/36 ,  G02B21/00

CPC classification number: H04N5/23212 ,  G02B7/36 ,  G02B21/006 ,  G02B21/244 ,  G02B21/365 ,  G02B21/367

Abstract: An image acquisition device reciprocates a focal position of an objective lens with respect to a sample in the optical axis direction of the objective lens, while moving a field position of the objective lens with respect to the sample. This makes it possible to acquire contrast information of image data at the field position of the objective lens sequentially as the field position moves with respect to the sample. The image acquisition device acquires the image data by the rolling readout of the image pickup element according to the reciprocation of the focal position of the objective lens.

Abstract translation: 在物镜相对于样品的场位置移动的同时，图像采集装置使物镜的焦点位置相对于物镜的光轴方向的样本往复运动。 这使得可以随着场位置相对于样本移动而顺序地获取物镜的场位置处的图像数据的对比度信息。 图像获取装置通过根据物镜的焦点位置的往复运动的图像拾取元件的滚动读出来获取图像数据。

公开(公告)号：US10598916B2

公开(公告)日：2020-03-24

申请号：US16407093

申请日：2019-05-08

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Fumio Iwase ,  Masatoshi Okugawa

IPC: G02B21/00 ,  G02B21/36 ,  H04N5/232 ,  G02B21/24 ,  G02B21/02 ,  G02B21/26 ,  G02B7/36

Abstract: In an image acquisition device, an optical path difference generating member can form an optical path length difference of a second optical image without splitting light in a second optical path. This can suppress the quantity of light required for the second optical path to obtain information of the focal position, whereby a quantity of light can be secured for a first imaging device to capture an image. The image acquisition device synchronizes the movement of a predetermined part of a sample within a field of an objective lens with rolling readout such that each pixel column of a second imaging device is exposed to an optical image of the predetermined part in the sample.

公开(公告)号：US10330910B2

公开(公告)日：2019-06-25

申请号：US14786576

申请日：2014-04-21

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Fumio Iwase ,  Masatoshi Okugawa

IPC: G02B21/00 ,  G02B21/36 ,  G02B7/36 ,  G02B21/24 ,  H04N5/232 ,  G02B21/02 ,  G02B21/26

Abstract: In an image acquisition device, an optical path difference generating member can form an optical path length difference of a second optical image without splitting light in a second optical path. This can suppress the quantity of light required for the second optical path to obtain information of the focal position, whereby a quantity of light can be secured for a first imaging device to capture an image. The image acquisition device synchronizes the movement of a predetermined part of a sample within a field of an objective lens with rolling readout such that each pixel column of a second imaging device is exposed to an optical image of the predetermined part in the sample.

公开(公告)号：US20150296126A1

公开(公告)日：2015-10-15

申请号：US14439000

申请日：2013-07-24

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masatoshi Okugawa ,  Jinichi Susuki ,  Hideshi Oishi

IPC: H04N5/232 ,  G06T7/00 ,  G02B21/24 ,  H04N5/222

CPC classification number: H04N5/23212 ,  G02B7/36 ,  G02B21/244 ,  G02B21/247 ,  G02B21/26 ,  G02B21/367 ,  G06T2207/10056 ,  G06T2207/30004 ,  H04N5/2226

Abstract: An image capturing apparatus is configured to store the control result of a focus position during scanning of segmented regions and determine an initial focus position in scanning of the (n+1)th segmented region, based on the control result stored during scanning of the nth (n is an integer of 1 or more) or earlier segmented region. The foregoing technique allows this image capturing apparatus to roughly determine the initial focus position in the next-scanned segmented region by making use of the control result of the segmented region the scanning of which has been already completed. This can suppress increase in processing time necessary for imaging, by simplification of pre-focus.

Abstract translation: 图像拍摄装置被配置为在分割区域的扫描期间存储聚焦位置的控制结果，并且基于在第n（n）个扫描期间存储的控制结果来确定在第（n + 1）个分割区域的扫描中的初始聚焦位置 （n为1以上的整数）或较早的分割区域。 上述技术允许该图像捕获设备通过利用其扫描已经完成的分割区域的控制结果粗略地确定下一扫描的分段区域中的初始聚焦位置。 这可以通过简化预聚焦来抑制成像所需的处理时间的增加。

公开(公告)号：US10348954B2

公开(公告)日：2019-07-09

申请号：US14786581

申请日：2014-04-21

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Fumio Iwase ,  Masatoshi Okugawa

IPC: G02B21/00 ,  H04N5/232 ,  G02B7/36 ,  G02B21/24 ,  G02B21/36

Abstract: An image acquisition device reciprocates a focal position of an objective lens with respect to a sample in the optical axis direction of the objective lens, while moving a field position of the objective lens with respect to the sample. This makes it possible to acquire contrast information of image data at the field position of the objective lens sequentially as the field position moves with respect to the sample. The image acquisition device acquires the image data by the rolling readout of the image pickup element according to the reciprocation of the focal position of the objective lens.

公开(公告)号：US20150160447A1

公开(公告)日：2015-06-11

申请号：US14410854

申请日：2013-03-19

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masatoshi Okugawa ,  Hiroshi Tanabe

IPC: G02B21/24 ,  G02B21/02 ,  H04N5/225 ,  G02B21/26

CPC classification number: G02B21/244 ,  G02B21/02 ,  G02B21/241 ,  G02B21/26 ,  H04N5/2254 ,  H04N5/23212

Abstract: The microscope imaging system is provided with: a stage having a mount face on which a specimen is to be mounted; an imaging unit having an imaging element for imaging a part of an imaging region set on the mount face; and a optical unit arranged between the stage and the imaging unit and having an objective lens for imaging light from a part of the imaging region onto the imaging unit. The specimen is arranged so that the mount face is orthogonal to an optical axis of the objective lens.

Abstract translation: 显微镜成像系统具有：具有安装面的台，其上安装试样; 成像单元，其具有用于对设置在所述安装面上的摄像区域的一部分进行成像的摄像元件; 以及光学单元，其布置在所述平台和所述成像单元之间并且具有用于将来自所述成像区域的一部分的光成像到所述成像单元上的物镜。 样本被布置成使得安装面与物镜的光轴正交。