公开(公告)号：US11670400B2

公开(公告)日：2023-06-06

申请号：US16752513

申请日：2020-01-24

Applicant: Google LLC

Inventor： Michelle Therese Hoerner Dimon ,  Marc Berndl ,  Marc Adlai Coram ,  Brian Trippe ,  Patrick F. Riley ,  Philip Charles Nelson

IPC: G06N3/08 ,  G16B40/20 ,  G16B40/00 ,  G06N3/045

CPC classification number: G16B40/20 ,  G06N3/08 ,  G16B40/00 ,  G06N3/045

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for obtaining data defining a sequence for an aptamer, the aptamer comprising a string of nucleobases; encoding the data defining the sequence for the aptamer as a neural network input; and processing the neural network input using a neural network to generate an output that characterizes how strongly the aptamer binds to a particular target molecule, wherein the neural network has been configured through training to receive the data defining the sequence and to process the data to generate predicted outputs that characterize how strongly the aptamer binds to the particular target molecule.

公开(公告)号：US20240006027A1

公开(公告)日：2024-01-04

申请号：US18307748

申请日：2023-04-26

Applicant: Google LLC

Inventor： Michelle Therese Hoerner Dimon ,  Marc Berndl ,  Marc Adlai Coram ,  Brian Trippe ,  Patrick F. Riley ,  Philip Charles Nelson

IPC: G16B40/20 ,  G16B40/00 ,  G06N3/08

CPC classification number: G16B40/20 ,  G16B40/00 ,  G06N3/08 ,  G06N3/045

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for obtaining data defining a sequence for an aptamer, the aptamer comprising a string of nucleobases; encoding the data defining the sequence for the aptamer as a neural network input; and processing the neural network input using a neural network to generate an output that characterizes how strongly the aptamer binds to a particular target molecule, wherein the neural network has been configured through training to receive the data defining the sequence and to process the data to generate predicted outputs that characterize how strongly the aptamer binds to the particular target molecule.

公开(公告)号：US11834756B2

公开(公告)日：2023-12-05

申请号：US17019121

申请日：2020-09-11

Applicant: Google LLC

Inventor： Annalisa Marie Pawlosky ,  Michael Gibbons ,  Sara Ahadi ,  Shirley Jing Shao ,  Anna Le ,  Ali Bashir ,  Marc Berndl ,  Michelle Therese Hoerner Dimon ,  Lauren Schiff

IPC: C12Q1/68 ,  C40B30/04 ,  C40B70/00 ,  C12Q1/6806 ,  C40B40/04 ,  C12Q1/6869

CPC classification number: C40B30/04 ,  C12Q1/6806 ,  C12Q1/6869 ,  C40B40/04 ,  C40B70/00 ,  C12Q2525/205

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.

公开(公告)号：US11834664B2

公开(公告)日：2023-12-05

申请号：US17019109

申请日：2020-09-11

Applicant: Google LLC

Inventor： Annalisa Marie Pawlosky ,  Zachary Cutts ,  Shirley Jing Shao ,  Michelle Therese Hoerner Dimon ,  Marc Berndl ,  Alexander Julian Tran ,  Diana Terri Wu

IPC: C12N15/115

CPC classification number: C12N15/115 ,  C12N2330/30

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.

公开(公告)号：US20240209378A1

公开(公告)日：2024-06-27

申请号：US18496219

申请日：2023-10-27

Applicant: Google LLC

Inventor： Annalisa Marie Pawlosky ,  Zachary Cutts ,  Shirley Jing Shao ,  Michelle Therese Hoerner Dimon ,  Marc Berndl ,  Alexander Julian Tran ,  Diana Terri Wu

IPC: C12N15/115

CPC classification number: C12N15/115 ,  C12N2330/30

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.

公开(公告)号：US20210079398A1

公开(公告)日：2021-03-18

申请号：US17019109

申请日：2020-09-11

Applicant: Google LLC

Inventor： Annalisa Marie Pawlosky ,  Zachary Cutts ,  Shirley Jing Shao ,  Michelle Therese Hoerner Dimon ,  Marc Berndl ,  Alexander Julian Tran ,  Diana Terri Wu

IPC: C12N15/115

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.

公开(公告)号：US10546650B2

公开(公告)日：2020-01-28

申请号：US14921973

申请日：2015-10-23

Applicant: Google LLC

Inventor： Michelle Therese Hoerner Dimon ,  Marc Berndl ,  Marc Adlai Coram ,  Brian Trippe ,  Patrick F. Riley ,  Philip Charles Nelson

IPC: G16B40/00 ,  G06N3/08 ,  G06N3/04

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for obtaining data defining a sequence for an aptamer, the aptamer comprising a string of nucleobases; encoding the data defining the sequence for the aptamer as a neural network input; and processing the neural network input using a neural network to generate an output that characterizes how strongly the aptamer binds to a particular target molecule, wherein the neural network has been configured through training to receive the data defining the sequence and to process the data to generate predicted outputs that characterize how strongly the aptamer binds to the particular target molecule.

公开(公告)号：US11926820B2

公开(公告)日：2024-03-12

申请号：US17019084

申请日：2020-09-11

Applicant: Google LLC

Inventor： Annalisa Marie Pawlosky ,  Michael Gibbons ,  Shirley Jing Shao ,  Marc Berndl ,  Michelle Therese Hoerner Dimon ,  Ali Bashir ,  Lauren Schiff

IPC: C12N15/10

CPC classification number: C12N15/1048

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.

公开(公告)号：US20210171937A1

公开(公告)日：2021-06-10

申请号：US17019084

申请日：2020-09-11

Applicant: Google LLC

Inventor： Annalisa Marie Pawlosky ,  Michael Gibbons ,  Shirley Jing Shao ,  Marc Berndl ,  Michelle Therese Hoerner Dimon ,  Ali Bashir

IPC: C12N15/10

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.

公开(公告)号：US20210102248A1

公开(公告)日：2021-04-08

申请号：US17019119

申请日：2020-09-11

Applicant: Google LLC

Inventor： Annalisa Marie Pawlosky ,  Jessica Hong ,  Shirley Jing Shao ,  Victoria A. Church ,  Michelle Therese Hoerner Dimon ,  Marc Berndl

IPC: C12Q1/6869 ,  C12Q1/686 ,  C12Q1/6876 ,  C12N15/10

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.