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公开(公告)号:US11670400B2
公开(公告)日:2023-06-06
申请号:US16752513
申请日:2020-01-24
Applicant: Google LLC
Inventor: Michelle Therese Hoerner Dimon , Marc Berndl , Marc Adlai Coram , Brian Trippe , Patrick F. Riley , Philip Charles Nelson
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for obtaining data defining a sequence for an aptamer, the aptamer comprising a string of nucleobases; encoding the data defining the sequence for the aptamer as a neural network input; and processing the neural network input using a neural network to generate an output that characterizes how strongly the aptamer binds to a particular target molecule, wherein the neural network has been configured through training to receive the data defining the sequence and to process the data to generate predicted outputs that characterize how strongly the aptamer binds to the particular target molecule.
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公开(公告)号:US12086702B2
公开(公告)日:2024-09-10
申请号:US18303134
申请日:2023-04-19
Applicant: Google LLC
Inventor: Patrick F. Riley , Marc Berndl
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for receiving graph data representing an input graph comprising a plurality of vertices connected by edges; generating, from the graph data, vertex input data representing characteristics of each vertex in the input graph and pair input data representing characteristics of pairs of vertices in the input graph; and generating order-invariant features of the input graph using a neural network, wherein the neural network comprises: a first subnetwork configured to generate a first alternative representation of the vertex input data and a first alternative representation of the pair input data from the vertex input data and the pair input data; and a combining layer configured to receive an input alternative representation and to process the input alternative representation to generate the order-invariant features.
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公开(公告)号:US20240006027A1
公开(公告)日:2024-01-04
申请号:US18307748
申请日:2023-04-26
Applicant: Google LLC
Inventor: Michelle Therese Hoerner Dimon , Marc Berndl , Marc Adlai Coram , Brian Trippe , Patrick F. Riley , Philip Charles Nelson
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for obtaining data defining a sequence for an aptamer, the aptamer comprising a string of nucleobases; encoding the data defining the sequence for the aptamer as a neural network input; and processing the neural network input using a neural network to generate an output that characterizes how strongly the aptamer binds to a particular target molecule, wherein the neural network has been configured through training to receive the data defining the sequence and to process the data to generate predicted outputs that characterize how strongly the aptamer binds to the particular target molecule.
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公开(公告)号:US11334770B1
公开(公告)日:2022-05-17
申请号:US16983136
申请日:2020-08-03
Applicant: Google LLC
Inventor: Dale M. Ando , Marc Berndl
Abstract: The present disclosure relates to phenotype analysis of cellular image data using a deep metric network. One example embodiment includes a method. The method includes receiving a target image of a target biological cell having a target phenotype. The method also includes obtaining a semantic embedding associated with the target image. The semantic embedding is generated using a machine-learned, deep metric network model. Further, the method includes obtaining, for each of a plurality of candidate images of candidate biological cells each having a respective candidate phenotype, a semantic embedding associated with the respective candidate image. In addition, the method includes identifying, for each of the semantic embeddings, common morphological variations and reducing, for each of the semantic embeddings based on the identified common morphological variations, effects of nuisances. Even further, the method includes determining, by the computing device, a similarity score for each candidate image.
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公开(公告)号:US10769501B1
公开(公告)日:2020-09-08
申请号:US16133542
申请日:2018-09-17
Applicant: Google LLC
Inventor: Dale M. Ando , Marc Berndl , Lusann Yang , Michelle Dimon
Abstract: The present disclosure relates to analysis of perturbed subjects using semantic embeddings. One example embodiment includes a method. The method includes applying a respective perturbation to each of a plurality of subjects in a controlled environment. The method also includes producing a respective visual representation for each of the perturbed subjects using at least one imaging modality. Further, the method includes obtaining, by a computing device for each of the respective visual representations, a corresponding semantic embedding associated with the respective visual representation. The semantic embedding associated with the respective visual representation is generated using a machine-learned, deep metric network model. In addition, the method includes classifying, by the computing device based on the corresponding semantic embedding, each of the visual representations into one or more groups.
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公开(公告)号:US10467754B1
公开(公告)日:2019-11-05
申请号:US15808699
申请日:2017-11-09
Applicant: Google LLC
Inventor: Dale M. Ando , Marc Berndl
Abstract: The present disclosure relates to a phenotype analysis of cellular image data using a deep metric network. One example embodiment includes a method. The method includes receiving, by a computing device, a plurality of candidate images of candidate biological cells each having a respective candidate phenotype. The method also includes obtaining, by the computing device for each of the plurality of candidate images, a semantic embedding associated with the respective candidate image. Further, the method includes grouping, by the computing device, the plurality of candidate images into a plurality of phenotypic strata based on their respective semantic embeddings.
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公开(公告)号:US20180349770A1
公开(公告)日:2018-12-06
申请号:US15979104
申请日:2018-05-14
Applicant: Google LLC
Inventor: Philip Charles Nelson , Eric Martin Christiansen , Marc Berndl , Michael Frumkin
CPC classification number: G06N3/08 , G06K9/00127 , G06N3/02 , G06N3/0454 , G06T7/60 , G06T2207/20084
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing cell images using neural networks. One of the methods includes obtaining data comprising an input image of one or more biological cells illuminated with an optical microscopy technique; processing the data using a stained cell neural network; and processing the one or more stained cell images using a cell characteristic neural network, wherein the cell characteristic neural network has been configured through training to receive the one or more stained cell images and to process the one or more stained cell images to generate a cell characteristic output that characterizes features of the biological cells that are stained in the one or more stained cell images.
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公开(公告)号:US11834756B2
公开(公告)日:2023-12-05
申请号:US17019121
申请日:2020-09-11
Applicant: Google LLC
Inventor: Annalisa Marie Pawlosky , Michael Gibbons , Sara Ahadi , Shirley Jing Shao , Anna Le , Ali Bashir , Marc Berndl , Michelle Therese Hoerner Dimon , Lauren Schiff
IPC: C12Q1/68 , C40B30/04 , C40B70/00 , C12Q1/6806 , C40B40/04 , C12Q1/6869
CPC classification number: C40B30/04 , C12Q1/6806 , C12Q1/6869 , C40B40/04 , C40B70/00 , C12Q2525/205
Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.
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公开(公告)号:US11834664B2
公开(公告)日:2023-12-05
申请号:US17019109
申请日:2020-09-11
Applicant: Google LLC
Inventor: Annalisa Marie Pawlosky , Zachary Cutts , Shirley Jing Shao , Michelle Therese Hoerner Dimon , Marc Berndl , Alexander Julian Tran , Diana Terri Wu
IPC: C12N15/115
CPC classification number: C12N15/115 , C12N2330/30
Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.
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公开(公告)号:US11443190B2
公开(公告)日:2022-09-13
申请号:US16905714
申请日:2020-06-18
Applicant: Google LLC
Inventor: Philip Charles Nelson , Eric Martin Christiansen , Marc Berndl , Michael Frumkin
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing cell images using neural networks. One of the methods includes obtaining data comprising an input image of one or more biological cells illuminated with an optical microscopy technique; processing the data using a stained cell neural network; and processing the one or more stained cell images using a cell characteristic neural network, wherein the cell characteristic neural network has been configured through training to receive the one or more stained cell images and to process the one or more stained cell images to generate a cell characteristic output that characterizes features of the biological cells that are stained in the one or more stained cell images.
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