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Patent Agency Ranking
公开(公告)号：US20160199457A1
公开(公告)日：2016-07-14
申请号：US14644873
申请日：2015-03-11
Applicant: GENENTECH, INC.
Inventor： Joseph Wesley LEWCOCK , Christine POZNIAK , Arundhati SENGUPTA-GHOSH
IPC: A61K38/45
CPC classification number: A61K38/45 , A61K31/7088 , A61K31/7105 , A61K31/715 , A61K35/30 , A61K38/005 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K16/40 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C12N15/1137 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12Y207/11025 , A61K2300/00
Abstract: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
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公开(公告)号：US20160279190A1
公开(公告)日：2016-09-29
申请号：US14755809
申请日：2015-06-30
Applicant: GENENTECH, INC.
Inventor： Ryan J. WATTS , Mark CHEN , Joseph Wesley LEWCOCK , Christine POZNIAK , Arundhati SENGUPTA-GHOSH
IPC: A61K38/12 , A61K31/4015 , A61K31/433 , A61K31/519 , A61K31/426 , A61K31/12 , A61K33/14 , A61K31/4439 , A61K31/506 , A61K31/277 , A61K31/517 , A61K31/165 , A61K31/5377 , A61K31/52 , A61K31/352 , A61K31/4184 , A61K31/496 , A61K31/505 , A61K31/40 , A61K31/45 , C12N15/113 , A61K31/713 , C07K16/40 , A61K38/05
CPC classification number: A61K38/12 , A61K31/12 , A61K31/165 , A61K31/277 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/4439 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K33/14 , A61K38/05 , A61K38/185 , C07K16/22 , C07K16/40 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/30 , G01N33/5058
Abstract: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
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公开(公告)号：US20160161470A1
公开(公告)日：2016-06-09
申请号：US14822711
申请日：2015-08-10
Applicant: GENENTECH, INC.
Inventor： Ryan J. WATTS , Mark CHEN , Joseph Wesley LEWCOCK , Christine POZNIAK , Arundhati SENGUPTA-GHOSH
IPC: G01N33/50 , C07K16/22 , A61K31/35 , A61K38/05 , A61K31/4015 , C12N15/113 , A61K31/52 , A61K31/277 , A61K33/14 , A61K31/4439 , A61K31/506 , A61K31/416 , A61K38/18 , A61K31/5377
CPC classification number: A61K38/12 , A61K31/12 , A61K31/165 , A61K31/277 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/4439 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K33/14 , A61K38/05 , A61K38/185 , C07K16/22 , C07K16/40 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/30 , G01N33/5058
Abstract: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
Abstract translation: 本发明一般涉及治疗神经系统疾病和神经系统损伤。 本发明具体提供了使用特定靶蛋白的调节剂调节神经元或其部分如轴突的变性的方法。
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公开(公告)号：US20180325992A1
公开(公告)日：2018-11-15
申请号：US15908024
申请日：2018-02-28
Applicant: Genentech, Inc.
Inventor： Ryan J. WATTS , Mark CHEN , Joseph Wesley LEWCOCK , Christine POZNIAK , Arundhati SENGUPTA-GHOSH
IPC: A61K38/12 , A61K31/711 , A61K31/7105 , C12N15/113 , A61K31/40 , A61K31/426 , A61K31/433 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/713 , C07K16/40 , A61K31/12 , A61K31/165 , A61K31/352 , A61K31/4184 , A61K31/277 , A61K31/35 , A61K31/4015 , A61K31/416 , A61K31/4439 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K33/14 , A61K38/05 , A61K38/18 , C07K16/22 , G01N33/50 , A61K31/7088
CPC classification number: A61K38/12 , A61K31/12 , A61K31/165 , A61K31/277 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/4439 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K33/14 , A61K38/05 , A61K38/185 , C07K16/22 , C07K16/40 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/30 , G01N33/5058
Abstract: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
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公开(公告)号：US20150361184A1
公开(公告)日：2015-12-17
申请号：US14839813
申请日：2015-08-28
Applicant: GENENTECH, INC.
Inventor： Daisy BUSTOS , Sarah HUNTWORK-RODRIGUEZ , Donald KIRKPATRICK , Joseph Wesley LEWCOCK , Arundhati Sengupta GHOSH
IPC: C07K16/40 , C12N15/113 , A61K31/7052 , A61K45/06 , A61K39/395 , G01N33/573 , A61K38/02
CPC classification number: C07K16/40 , A61K31/7052 , A61K31/7105 , A61K38/02 , A61K39/3955 , A61K45/06 , C07K2317/34 , C07K2317/40 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C12N15/1137 , C12N2310/14 , G01N33/573 , G01N2333/912 , G01N2440/14 , G01N2800/7004 , A61K2300/00
Abstract: The invention provides for methods of decreasing dual leucine zipper kinase (DLK) stability in a neuron, or decreasing or inhibiting the phosphorylation of certain amino acid residues of DLK, comprising administering to a neuron, or portion thereof, an agent which decreases or inhibits the phosphorylation of DLK and decreases the stability of DLK as well as methods for inhibiting or preventing neuronal degeneration in a patient by administering to a patient an agent which inhibits phosphorylation of dual leucine zipper kinase (DLK).
Abstract translation: 本发明提供减少神经元中双重亮氨酸拉链激酶（DLK）稳定性或降低或抑制DLK的某些氨基酸残基的磷酸化的方法，包括向神经元或其部分施用减少或抑制 通过向患者施用抑制双重亮氨酸拉链激酶（DLK）磷酸化的药剂，DLK的磷酸化和降低DLK的稳定性以及抑制或预防患者神经元变性的方法。
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