公开(公告)号：US20150361184A1

公开(公告)日：2015-12-17

申请号：US14839813

申请日：2015-08-28

Applicant: GENENTECH, INC.

Inventor： Daisy BUSTOS ,  Sarah HUNTWORK-RODRIGUEZ ,  Donald KIRKPATRICK ,  Joseph Wesley LEWCOCK ,  Arundhati Sengupta GHOSH

IPC: C07K16/40 ,  C12N15/113 ,  A61K31/7052 ,  A61K45/06 ,  A61K39/395 ,  G01N33/573 ,  A61K38/02

CPC classification number: C07K16/40 ,  A61K31/7052 ,  A61K31/7105 ,  A61K38/02 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/76 ,  C12N15/1137 ,  C12N2310/14 ,  G01N33/573 ,  G01N2333/912 ,  G01N2440/14 ,  G01N2800/7004 ,  A61K2300/00

Abstract: The invention provides for methods of decreasing dual leucine zipper kinase (DLK) stability in a neuron, or decreasing or inhibiting the phosphorylation of certain amino acid residues of DLK, comprising administering to a neuron, or portion thereof, an agent which decreases or inhibits the phosphorylation of DLK and decreases the stability of DLK as well as methods for inhibiting or preventing neuronal degeneration in a patient by administering to a patient an agent which inhibits phosphorylation of dual leucine zipper kinase (DLK).

Abstract translation: 本发明提供减少神经元中双重亮氨酸拉链激酶（DLK）稳定性或降低或抑制DLK的某些氨基酸残基的磷酸化的方法，包括向神经元或其部分施用减少或抑制 通过向患者施用抑制双重亮氨酸拉链激酶（DLK）磷酸化的药剂，DLK的磷酸化和降低DLK的稳定性以及抑制或预防患者神经元变性的方法。