公开(公告)号：US20240101708A1

公开(公告)日：2024-03-28

申请号：US18363155

申请日：2023-08-01

Applicant: Genentech Inc.

Inventor： Nicholas John Agard ,  Felipe de Sousa e Melo ,  Jing Li ,  Hadir Mohamed Gehad Mohamed Fouad Elsayed Marei ,  Wen-Ting K. Tsai ,  Frederic Joseph De Sauvage ,  Jieyan He ,  Yee Seir Kee

IPC: C07K16/40 ,  A61P35/00

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/565

Abstract: The present disclosure relates to a multispecific antibody platform for targeted degradation of cell surface proteins. The disclosure relates to multispecific (e.g., bispecific or trispecific) binding molecules such as multispecific antibodies that target at least one transmembrane E3 ubiquitin ligase protein and at least one cell surface protein, for example, a cell surface protein that is intended for degradation, and methods of using the same.

公开(公告)号：US11066389B2

公开(公告)日：2021-07-20

申请号：US16718602

申请日：2019-12-18

Applicant: Genentech, Inc.

Inventor： Jinguang Lin ,  Alexandra Chestakova ,  Wei Gu ,  Hans Iding ,  Jing Li ,  Xin Linghu ,  Patrik Meier ,  Chunbo Sha ,  Jeffrey Stults ,  Youchu Wang ,  Haiming Zhang ,  Jianqian Zhang ,  Tao Zhang

IPC: C07D401/14 ,  C07D401/04 ,  A61P35/00 ,  A61P25/00 ,  A61P29/00 ,  C12P17/16

Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid

公开(公告)号：US11098028B2

公开(公告)日：2021-08-24

申请号：US16535752

申请日：2019-08-08

Applicant: Genentech, Inc.

Inventor： Jinguang Lin ,  Alexandra Chestakova ,  Wei Gu ,  Hans Iding ,  Jing Li ,  Xin Linghu ,  Patrik Meier ,  Chunbo Sha ,  Jeffrey Stults ,  Youchu Wang ,  Haiming Zhang ,  Jianqian Zhang ,  Tao Zhang

IPC: C07D401/14 ,  C07D401/04 ,  C12P17/16 ,  A61P35/00 ,  A61P25/00 ,  A61P29/00

Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid

公开(公告)号：US20180134685A1

公开(公告)日：2018-05-17

申请号：US15866899

申请日：2018-01-10

Applicant: Genentech, Inc.

Inventor： Jinguang Lin ,  Alexandra Chestakova ,  Wei Gu ,  Hans Iding ,  Jing Li ,  Xin Linghu ,  Patrik Meier ,  Chunbo Sha ,  Jeffrey Stults ,  Youchu Wang ,  Haiming Zhang ,  Jianqian Zhang ,  Tao Zhang

IPC: C07D401/14 ,  C07D401/04 ,  C12P17/16

CPC classification number: C07D401/14 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C12P17/165

Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid

公开(公告)号：US20170022183A1

公开(公告)日：2017-01-26

申请号：US15285781

申请日：2016-10-05

Applicant: Genentech, Inc.

Inventor： Jinguang Lin ,  Alexandra Chestakova ,  Wei Gu ,  Hans Iding ,  Jing Li ,  Xin Linghu ,  Patrik Meier ,  Chunbo Sha ,  Jeffrey Stults ,  Youchu Wang ,  Haiming Zhang ,  Jianqian Zhang ,  Tao Zhang

IPC: C07D401/14 ,  C12P17/16 ,  C07D401/04

CPC classification number: C07D401/14 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C12P17/165

Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid

Abstract translation: 本发明提供了制备式（Ⅷa）化合物和（Ⅷa）盐形式的方法，其中Rc是芳基磺酸。