公开(公告)号：US20240327528A1

公开(公告)日：2024-10-03

申请号：US18609758

申请日：2024-03-19

Applicant: Genentech, Inc.

Inventor： Minhong Yan ,  Gu Zhang ,  Nicholas John Agard ,  Danielle Marie DiCara ,  Philip E. Hass ,  Julie Q. Hang ,  Erin L. Christensen ,  Robert Paul Morse ,  Sarah Sanowar ,  Vittal Shivva

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/60 ,  A61K47/68 ,  A61P27/02

CPC classification number: C07K16/2863 ,  A61K9/0048 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6849 ,  A61P27/02 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92

Abstract: The invention provides Tie-2 antibodies and fragments thereof and conjugates and methods of using the same.

公开(公告)号：US20250122280A1

公开(公告)日：2025-04-17

申请号：US18927265

申请日：2024-10-25

Applicant: Genentech, Inc.

Inventor： Nicholas John Agard ,  Thomas Harden Pillow ,  Josefa Dela Cruz Chuh ,  Mary Ann T. Go ,  Katherine R. Kozak ,  Zhonghua Lin ,  Dhaya Seshasayee ,  Shang-Fan Yu ,  James Thomas Koerber ,  Yonglian Sun

IPC: C07K16/28 ,  A61K45/06 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  G01N33/574 ,  G01N33/68

Abstract: The invention provides anti-Ly6E antibodies and immunoconjugates, and methods of using the same.

公开(公告)号：US11999787B2

公开(公告)日：2024-06-04

申请号：US17208292

申请日：2021-03-22

Applicant: Genentech, Inc.

Inventor： Minhong Yan ,  Gu Zhang ,  Nicholas John Agard ,  Danielle Marie Dicara ,  Philip E. Hass ,  Julie Q. Hang ,  Erin L. Christensen ,  Robert Paul Morse ,  Sarah Sanowar ,  Vittal Shivva

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/60 ,  A61K47/68 ,  A61P27/02

CPC classification number: C07K16/2863 ,  A61K9/0048 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6849 ,  A61P27/02 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92

Abstract: The invention provides Tie-2 antibodies and fragments thereof and conjugates and methods of using the same.

公开(公告)号：US20240101708A1

公开(公告)日：2024-03-28

申请号：US18363155

申请日：2023-08-01

Applicant: Genentech Inc.

Inventor： Nicholas John Agard ,  Felipe de Sousa e Melo ,  Jing Li ,  Hadir Mohamed Gehad Mohamed Fouad Elsayed Marei ,  Wen-Ting K. Tsai ,  Frederic Joseph De Sauvage ,  Jieyan He ,  Yee Seir Kee

IPC: C07K16/40 ,  A61P35/00

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/565

Abstract: The present disclosure relates to a multispecific antibody platform for targeted degradation of cell surface proteins. The disclosure relates to multispecific (e.g., bispecific or trispecific) binding molecules such as multispecific antibodies that target at least one transmembrane E3 ubiquitin ligase protein and at least one cell surface protein, for example, a cell surface protein that is intended for degradation, and methods of using the same.