公开(公告)号：US20240101708A1

公开(公告)日：2024-03-28

申请号：US18363155

申请日：2023-08-01

Applicant: Genentech Inc.

Inventor： Nicholas John Agard ,  Felipe de Sousa e Melo ,  Jing Li ,  Hadir Mohamed Gehad Mohamed Fouad Elsayed Marei ,  Wen-Ting K. Tsai ,  Frederic Joseph De Sauvage ,  Jieyan He ,  Yee Seir Kee

IPC: C07K16/40 ,  A61P35/00

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/565

Abstract: The present disclosure relates to a multispecific antibody platform for targeted degradation of cell surface proteins. The disclosure relates to multispecific (e.g., bispecific or trispecific) binding molecules such as multispecific antibodies that target at least one transmembrane E3 ubiquitin ligase protein and at least one cell surface protein, for example, a cell surface protein that is intended for degradation, and methods of using the same.