公开(公告)号：US20210188775A1

公开(公告)日：2021-06-24

申请号：US17249457

申请日：2021-03-02

申请人： Genentech, Inc.

发明人： Christian CUNNINGHAM ,  Paul Powell BEROZA ,  James John CRAWFORD ,  Wendy Lee ,  Olivier RENE ,  Jason Robert ZBIEG ,  Jiangpeng LIAO ,  Tao WANG ,  Chen YU

IPC分类号： C07D213/76 ,  C07C311/08 ,  C07C303/40 ,  C07C235/46 ,  C07C231/14 ,  C07D213/82 ,  C07D209/08 ,  C07D237/24

摘要： The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20230079990A1

公开(公告)日：2023-03-16

申请号：US17592422

申请日：2022-02-03

申请人： Genentech, Inc.

发明人： Jun LIANG ,  Araz JAKALIAN ,  Michael John LAMBRECHT ,  Robin LAROUCHE-GAUTHIER ,  Malcolm HUESTIS ,  Man Un UNG ,  Xiaojing WANG ,  Arun YADAV ,  Jason Robert ZBIEG ,  Fabio BROCCATELLI

IPC分类号： C07D405/14 ,  C07D491/107 ,  C07D403/10 ,  C07D403/14 ,  C07D401/14 ,  C07D409/14 ,  A61P35/00

摘要： Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same. Representative lactam compounds include molecules falling within the following formulae:

公开(公告)号：US20230212153A1

公开(公告)日：2023-07-06

申请号：US18052851

申请日：2022-11-04

申请人： Genentech, Inc.

发明人： Malcolm HUESTIS ,  Michael John LAMBRECHT ,  Jun LIANG ,  Man Un UNG ,  Xiaojing WANG ,  Jason Robert ZBIEG ,  Bing-Yan Zhu ,  Lisa Marie BARTON ,  Fabio BROCCATELLI ,  Georgette Marie CASTANEDO ,  Araz JAKALIAN ,  Robin LAROUCHE-GAUTHIER ,  Arun YADAV

IPC分类号： C07D403/12 ,  A61P35/00 ,  C07D493/08 ,  C07D405/14 ,  C07D403/14 ,  C07D409/14 ,  C07D401/14

CPC分类号： C07D403/12 ,  A61P35/00 ,  C07D493/08 ,  C07D405/14 ,  C07D403/14 ,  C07D409/14 ,  C07D401/14

摘要： A compound, of formula (I):




suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

公开(公告)号：US20230203062A1

公开(公告)日：2023-06-29

申请号：US18057742

申请日：2022-11-21

申请人： Genentech, Inc.

发明人： Jason Robert ZBIEG ,  Paul Powell BEROZA ,  Vishal Anil VERMA ,  Bing-Yan ZHU ,  Ramsay BEVERIDGE ,  Liang ZHAO ,  Melissa LEBLANC ,  Lisa Marie BARTON ,  Bryan Ka Ip CHAN ,  Samir BOUAYAD-GERVAIS ,  Anwesha DEY ,  Marie Anne EVANGELISTA ,  Russell Tyler SMITH

IPC分类号： C07D513/04 ,  C07D307/81 ,  C07D413/04 ,  C07D491/052 ,  C07D471/04 ,  C07D239/74 ,  C07D491/048 ,  C07D498/04 ,  C07D215/12 ,  C07D405/08 ,  C07D403/06 ,  C07D235/14 ,  C07D487/04 ,  C07D241/42 ,  C07D263/56

CPC分类号： C07D513/04 ,  C07D307/81 ,  C07D413/04 ,  C07D491/052 ,  C07D471/04 ,  C07D239/74 ,  C07D491/048 ,  C07D498/04 ,  C07D215/12 ,  C07D405/08 ,  C07D403/06 ,  C07D235/14 ,  C07D487/04 ,  C07D241/42 ,  C07D263/56

摘要： This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.