Patent search ap:("Genentech Page Inc.") AND inv:"Xiaojing WANG"

1.

发明申请
OXEPAN-2-YL-PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE 审中-公开
Title translation: OXEPAN-2-YL-PYRAZOL-4-YL-杂环碳酰胺化合物及其使用方法

公开(公告)号：US20170001997A1

公开(公告)日：2017-01-05

申请号：US15266243

申请日：2016-09-15

Applicant: Genentech, Inc.

Inventor： Jason BURCH , Huifen CHEN , Xiaojing WANG

IPC: C07D417/14 , A61K31/427 , A61K31/497 , A61K31/4439 , A61K31/4985 , A61K31/4709 , C07D487/04 , A61K45/06

CPC classification number: C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K45/06 , C07D487/04

Abstract: Oxepan-2-yl pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract translation: 包括立体异构体，几何异构体，互变异构体及其药学上可接受的盐，其中X是噻唑基，吡嗪基，吡啶基或嘧啶基的式I的氧杂环庚烷-2-基吡唑-4-基 - 杂环基 - 甲酰胺化合物可用于抑制Pim 激酶，并用于治疗由Pim激酶介导的疾病如癌症。公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

2.

发明公开
TREATMENT OF BREAST CANCER USING COMBINATION THERAPIES COMPRISING GDC-9545 AND GDC-0077 审中-公开

公开(公告)号：US20230381155A1

公开(公告)日：2023-11-30

申请号：US18449800

申请日：2023-08-15

Applicant: Genentech, Inc.

Inventor： Ciara METCALFE , Xiaojing WANG , Wei ZHOU

IPC: A61K31/437 , A61K31/553 , A61P35/00 , A61P35/04

CPC classification number: A61K31/437 , A61K31/553 , A61P35/00 , A61P35/04

Abstract: Provided herein are combination therapies comprising GDC-9545 and GDC-0077 for treating locally advanced breast cancer or metastatic breast cancer.

3.

发明申请
LACTAMS AS CBL-B INHIBITORS 有权

公开(公告)号：US20230079990A1

公开(公告)日：2023-03-16

申请号：US17592422

申请日：2022-02-03

Applicant: Genentech, Inc.

Inventor： Jun LIANG , Araz JAKALIAN , Michael John LAMBRECHT , Robin LAROUCHE-GAUTHIER , Malcolm HUESTIS , Man Un UNG , Xiaojing WANG , Arun YADAV , Jason Robert ZBIEG , Fabio BROCCATELLI

IPC: C07D405/14 , C07D491/107 , C07D403/10 , C07D403/14 , C07D401/14 , C07D409/14 , A61P35/00

Abstract: Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same. Representative lactam compounds include molecules falling within the following formulae:

4.

发明申请
PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE 有权
Title translation: 吡咯烷酮和AZA-吡咯烷酮化合物及其使用方法

公开(公告)号：US20140057896A1

公开(公告)日：2014-02-27

申请号：US14059626

申请日：2013-10-22

Applicant: GENENTECH, INC. , GILEAD CONNECTICUT, INC.

Inventor： Antonio J.M. BARBOSA , Peter A. BLOMGREN , Kevin S. CURRIE , Ravi KRISHNAMOORTHY , Jeffrey E. KROPF , Seung H. LEE , Scott A. MITCHELL , Daniel ORTWINE , Aaron C. SCHMITT , Xiaojing WANG , Jianjun XU , Wendy YOUNG , Honglu ZHANG , Zhongdong ZHAO , Pavel E. ZHICHKIN

IPC: C07D519/00 , C07D495/04 , C07D487/04 , C07D471/14 , A61K31/501 , A61K31/5386 , A61K31/4985 , A61K31/5377 , A61K31/5383 , A61K31/497 , A61K31/5025 , A61K31/551 , A61K45/06 , A61K31/506

CPC classification number: C07D519/00 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/551 , A61K45/06 , C07C69/65 , C07D209/52 , C07D471/14 , C07D487/04 , C07D495/04 , C07D498/04 , C07F5/04

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract translation: 提供式I的吡啶酮和氮杂 - 吡啶酮化合物，包括其可用于抑制Btk激酶的立体异构体，互变异构体及其药学上可接受的盐，以及用于治疗免疫疾病如Btk激酶介导的炎症。公开了使用式I化合物进行体外，原位和体内诊断以及哺乳动物细胞或相关病理学条件下的这些疾病的治疗的方法。

5.

发明公开
TREATMENT OF BREAST CANCER USING COMBINATION THERAPIES COMPRISING GDC-9545 AND ABEMACICLIB OR RIBOCICLIB 审中-公开

公开(公告)号：US20230381154A1

公开(公告)日：2023-11-30

申请号：US18449793

申请日：2023-08-15

Applicant: Genentech, Inc.

Inventor： Ciara METCALFE , Pablo Diego PEREZ-MORENO , Xiaojing WANG

IPC: A61K31/437 , A61K31/506 , A61K31/519

CPC classification number: A61K31/437 , A61K31/519 , A61K31/506

Abstract: Provided herein are combination therapies comprising GDC-9545 and abemaciclib or ribociclib for treating locally advanced breast cancer or metastatic breast cancer.