公开(公告)号：US20230079990A1

公开(公告)日：2023-03-16

申请号：US17592422

申请日：2022-02-03

Applicant: Genentech, Inc.

Inventor： Jun LIANG ,  Araz JAKALIAN ,  Michael John LAMBRECHT ,  Robin LAROUCHE-GAUTHIER ,  Malcolm HUESTIS ,  Man Un UNG ,  Xiaojing WANG ,  Arun YADAV ,  Jason Robert ZBIEG ,  Fabio BROCCATELLI

IPC: C07D405/14 ,  C07D491/107 ,  C07D403/10 ,  C07D403/14 ,  C07D401/14 ,  C07D409/14 ,  A61P35/00

Abstract: Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same. Representative lactam compounds include molecules falling within the following formulae:

公开(公告)号：US20230212153A1

公开(公告)日：2023-07-06

申请号：US18052851

申请日：2022-11-04

Applicant: Genentech, Inc.

Inventor： Malcolm HUESTIS ,  Michael John LAMBRECHT ,  Jun LIANG ,  Man Un UNG ,  Xiaojing WANG ,  Jason Robert ZBIEG ,  Bing-Yan Zhu ,  Lisa Marie BARTON ,  Fabio BROCCATELLI ,  Georgette Marie CASTANEDO ,  Araz JAKALIAN ,  Robin LAROUCHE-GAUTHIER ,  Arun YADAV

IPC: C07D403/12 ,  A61P35/00 ,  C07D493/08 ,  C07D405/14 ,  C07D403/14 ,  C07D409/14 ,  C07D401/14

CPC classification number: C07D403/12 ,  A61P35/00 ,  C07D493/08 ,  C07D405/14 ,  C07D403/14 ,  C07D409/14 ,  C07D401/14

Abstract: A compound, of formula (I):




suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.