公开(公告)号：US20230079990A1

公开(公告)日：2023-03-16

申请号：US17592422

申请日：2022-02-03

Applicant: Genentech, Inc.

Inventor： Jun LIANG ,  Araz JAKALIAN ,  Michael John LAMBRECHT ,  Robin LAROUCHE-GAUTHIER ,  Malcolm HUESTIS ,  Man Un UNG ,  Xiaojing WANG ,  Arun YADAV ,  Jason Robert ZBIEG ,  Fabio BROCCATELLI

IPC: C07D405/14 ,  C07D491/107 ,  C07D403/10 ,  C07D403/14 ,  C07D401/14 ,  C07D409/14 ,  A61P35/00

Abstract: Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same. Representative lactam compounds include molecules falling within the following formulae:

公开(公告)号：US20190284189A1

公开(公告)日：2019-09-19

申请号：US16421114

申请日：2019-05-23

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Daniel SHORE ,  Elisia VILLEMURE ,  Matthew VOLGRAF ,  Baihua HU ,  Aijun LU ,  Andrew CRIDLAND ,  Stuart WARD ,  Francis BEAUMIER ,  Martin DERY ,  Robin LAROUCHE-GAUTHIER

IPC: C07D473/30 ,  C07D471/04 ,  C07D513/04 ,  C07D487/04

Abstract: The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.

公开(公告)号：US20230212153A1

公开(公告)日：2023-07-06

申请号：US18052851

申请日：2022-11-04

Applicant: Genentech, Inc.

Inventor： Malcolm HUESTIS ,  Michael John LAMBRECHT ,  Jun LIANG ,  Man Un UNG ,  Xiaojing WANG ,  Jason Robert ZBIEG ,  Bing-Yan Zhu ,  Lisa Marie BARTON ,  Fabio BROCCATELLI ,  Georgette Marie CASTANEDO ,  Araz JAKALIAN ,  Robin LAROUCHE-GAUTHIER ,  Arun YADAV

IPC: C07D403/12 ,  A61P35/00 ,  C07D493/08 ,  C07D405/14 ,  C07D403/14 ,  C07D409/14 ,  C07D401/14

CPC classification number: C07D403/12 ,  A61P35/00 ,  C07D493/08 ,  C07D405/14 ,  C07D403/14 ,  C07D409/14 ,  C07D401/14

Abstract: A compound, of formula (I):




suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

公开(公告)号：US20200002340A1

公开(公告)日：2020-01-02

申请号：US16558718

申请日：2019-09-03

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Brian SAFINA ,  Daniel SHORE ,  Jack TERRETT ,  Elisia VILLEMURE ,  Matthew VOLGRAF ,  Stuart WARD ,  Aijun LU ,  Robin LAROUCHE-GAUTHIER ,  Francis BEAUMIER ,  Martin DERY ,  Lea CONSTANTINEAU-FORGET ,  Chantal GRAND-MAITRE ,  Luce LEPISSIER

IPC: C07D473/30 ,  C07D471/04 ,  C07D487/04 ,  C07D473/08

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.