公开(公告)号：US20150322153A1

公开(公告)日：2015-11-12

申请号：US14538072

申请日：2014-11-11

Applicant: GENENTECH, INC.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  A61K45/06 ,  A61K31/7068

CPC classification number: C07K16/2827 ,  A61K31/7068 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1063 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/489 ,  Y02A50/492 ,  A61K2300/00

Abstract: The present application relates to anti-PD-L1 antibodies, which have therapeutic use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

Abstract translation: 本申请涉及抗PD-L1抗体，其具有用于增强T细胞功能以上调细胞介导的免疫应答和用于治疗T细胞功能障碍性疾病（包括感染（例如急性和慢性））和肿瘤的治疗用途 免疫。

公开(公告)号：US20210032345A1

公开(公告)日：2021-02-04

申请号：US16854707

申请日：2020-04-21

Applicant: Genentech, Inc.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  C07K16/30 ,  A61K31/7068 ,  A61K39/395 ,  A61K45/06 ,  C07K16/10 ,  C07K16/22 ,  A61K39/00

Abstract: The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

公开(公告)号：US20160222117A1

公开(公告)日：2016-08-04

申请号：US14846457

申请日：2015-09-04

Applicant: GENENTECH, INC.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2827 ,  A61K31/7068 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1063 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/489 ,  Y02A50/492 ,  A61K2300/00

Abstract: The present application relates to nucleic acid encoding anti-PD-L1 antibodies, which have therapeutic use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

Abstract translation: 本申请涉及编码抗PD-L1抗体的核酸，其具有治疗用途，其具有增强T细胞功能以上调细胞介导的免疫应答和用于治疗T细胞功能障碍性疾病，包括感染（例如急性和慢性 ）和肿瘤免疫。

公开(公告)号：US20230287127A1

公开(公告)日：2023-09-14

申请号：US18160094

申请日：2023-01-26

Applicant: Genentech, Inc.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  C07K16/22 ,  A61K39/00 ,  A61K39/395 ,  C07K16/10 ,  A61K31/7068 ,  C07K16/30 ,  A61K45/06

CPC classification number: C07K16/2827 ,  A61K31/7068 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/1063 ,  C07K16/3046 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/567 ,  Y02A50/30

Abstract: The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

公开(公告)号：US20140161822A1

公开(公告)日：2014-06-12

申请号：US14077414

申请日：2013-11-12

Applicant: Genentech, Inc.

Inventor： Min XU ,  Mercedesz BALAZS ,  Ning CHAI ,  Nancy Chiang ,  Henry CHIU ,  Zhaoyu JIN ,  Zhonghua LIN ,  Patrick LUPARDUS ,  Gerald R. NAKAMURA ,  Hyunjoo PARK ,  Lee SWEM

IPC: C07K16/10

CPC classification number: C07K16/1018 ,  A61K31/215 ,  A61K31/235 ,  A61K31/24 ,  A61K39/42 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/94 ,  A61K2300/00

Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.

Abstract translation: 本发明提供抗血凝素抗体，包含抗血凝素抗体的组合物及其使用方法。

公开(公告)号：US20190016807A1

公开(公告)日：2019-01-17

申请号：US15881611

申请日：2018-01-26

Applicant: Genentech, Inc.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  C07K16/10 ,  C07K16/22 ,  A61K31/7068 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

公开(公告)号：US20170107287A1

公开(公告)日：2017-04-20

申请号：US15335278

申请日：2016-10-26

Applicant: Genentech, Inc.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2827 ,  A61K31/7068 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1063 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/492 ,  A61K2300/00

Abstract: The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

公开(公告)号：US20160168230A1

公开(公告)日：2016-06-16

申请号：US15042436

申请日：2016-02-12

Applicant: Genentech, Inc.

Inventor： Min XU ,  Mercedesz BALAZS ,  Ning CHA ,  Nancy CHIANG ,  Henry CHIU ,  Zhaoyu JIN ,  Zhonghua LIN ,  Patrick LUPARDUS ,  Gerald R. NAKAMURA ,  Hyunjoo PARK ,  Lee SWEM

IPC: C07K16/10 ,  A61K39/42 ,  A61K31/24

CPC classification number: C07K16/1018 ,  A61K31/215 ,  A61K31/235 ,  A61K31/24 ,  A61K39/42 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/94 ,  A61K2300/00

Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.

公开(公告)号：US20140134638A1

公开(公告)日：2014-05-15

申请号：US14077407

申请日：2013-11-12

Applicant: Genentech, Inc.

Inventor： Juan ZHANG ,  Mercedesz BALAZS ,  Ning CHAI ,  Henry CHIU ,  Wyne Pun LEE ,  Zhonghua LIN ,  Patrick LUPARDUS ,  Lee SWEM

IPC: C12N5/0789

CPC classification number: C07K16/1018 ,  C07K16/00 ,  C07K16/065 ,  C07K16/1282 ,  C07K2317/30 ,  C12N5/0635

Abstract: The present invention relates to methods for enrichment of antigen-specific plasmablasts. The methods are useful for the identification of antibodies, including rare antibodies which recognize more than one antigen.

Abstract translation: 本发明涉及用于富集抗原特异性浆细胞的方法。 该方法可用于鉴定抗体，包括识别多于一种抗原的罕见抗体。