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公开(公告)号：US20150368723A1
公开(公告)日：2015-12-24
申请号：US14744845
申请日：2015-06-19
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schlüter
IPC分类号： C12Q1/68
CPC分类号： G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
摘要： The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
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公开(公告)号：US10036753B2
公开(公告)日：2018-07-31
申请号：US14744845
申请日：2015-06-19
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schlüter
IPC分类号： C12Q1/686 , G01N33/574 , C12Q1/6886 , G06F19/22
CPC分类号： G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G16B30/00
摘要： The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
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公开(公告)号：US09919036B2
公开(公告)日：2018-03-20
申请号：US14606729
申请日：2015-01-27
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Dirk Usener
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
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公开(公告)号：US09751934B2
公开(公告)日：2017-09-05
申请号：US14661882
申请日：2015-03-18
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
IPC分类号： C07K16/00 , A61K39/395 , C07K16/18 , A61K47/48 , A61K51/10 , C07K16/30 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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5.发明申请Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy 审中-公开鉴定表面相关抗原的肿瘤诊断和治疗公开(公告)号：US20160193335A1
公开(公告)日：2016-07-07
申请号：US15009061
申请日：2016-01-28
发明人： Ozlem Tureci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schluter , Dirk Usener , Philippe Thiel , Michael Koslowski
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06 , C07K16/28
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： Disclosed is a method of diagnosing and treating a head neck cancer characterized by expressing a tumor-associated antigen having the amino acid sequence shown in SEQ ID NO:4. The method comprises treating the so-affected patient with an antibody which specifically binds to an extracellular portion of said tumor-associated antigen having the amino acid sequence of SEQ ID NO: 4.
摘要翻译： 公开了一种诊断和治疗头颈癌的方法，其特征在于表达具有SEQ ID NO：4所示氨基酸序列的肿瘤相关抗原。 该方法包括用特异性结合具有SEQ ID NO：4的氨基酸序列的所述肿瘤相关抗原的细胞外部分的抗体来治疗受影响的患者。
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公开(公告)号：US20150252103A1
公开(公告)日：2015-09-10
申请号：US14661846
申请日：2015-03-18
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
IPC分类号： C07K16/18 , A61K45/06 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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公开(公告)号：US10738108B2
公开(公告)日：2020-08-11
申请号：US15710252
申请日：2017-09-20
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
IPC分类号： C07H21/02 , A01N63/00 , C07K16/18 , A61K47/68 , A61K51/10 , C07K16/30 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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公开(公告)号：US10174104B2
公开(公告)日：2019-01-08
申请号：US14661846
申请日：2015-03-18
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
IPC分类号： C07K16/00 , A61K39/395 , C07K16/18 , A61K47/68 , A61K51/10 , C07K16/30 , A61K45/06 , C07K16/28 , A61K39/00
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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公开(公告)号：US20180127489A1
公开(公告)日：2018-05-10
申请号：US15710252
申请日：2017-09-20
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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公开(公告)号：US20160185860A1
公开(公告)日：2016-06-30
申请号：US15069511
申请日：2016-03-14
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
IPC分类号： C07K16/28
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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