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公开(公告)号：US20240317861A1
公开(公告)日：2024-09-26
申请号：US18539509
申请日：2023-12-14
Applicant: GENMAB A/S
Inventor： Isil ALTINTAS , David SATIJN , Edward VAN DEN BRINK , Dennis VERZIJL , Rik RADEMAKER , Paul PARREN , Bart DE GOEIJ
IPC: C07K16/28 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/42
CPC classification number: C07K16/2827 , A61K39/3955 , A61K45/06 , A61P35/00 , C07K16/2809 , C07K16/4258 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to novel antibodies and their use in medicine. In particular, the invention relates to bispecific antibodies capable of binding human PD-L1 and capable of binding human CD3. Novel classes of antibodies capable of binding human PD-L1 are also provided. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20200165349A1
公开(公告)日：2020-05-28
申请号：US16779011
申请日：2020-01-31
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK , Christian GRUNWITZ
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20160333095A1
公开(公告)日：2016-11-17
申请号：US15110414
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Edward Norbert VAN DEN BRINK , Joost J. NEIJSSEN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Isil ALTINTAS , Paul PARREN , Rik RADEMAKER
CPC classification number: C07K16/2809 , A61K2039/505 , C07K16/1063 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K16/4241 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/75 , C07K2317/90 , C07K2317/92 , G01N33/6872 , G01N2333/7051
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
Abstract translation: 本发明涉及结合CD3的人源化或嵌合抗体。 此外，它还涉及双特异性抗体，组合物，药物组合物，所述抗体在治疗疾病中的用途，以及治疗方法。
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公开(公告)号：US20220064317A1
公开(公告)日：2022-03-03
申请号：US17360437
申请日：2021-06-28
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US20190284278A1
公开(公告)日：2019-09-19
申请号：US15744317
申请日：2016-07-14
Applicant: GENMAB A/S
Inventor： Rik RADEMAKER , Isil ALTINTAS , Patrick ENGELBERTS , Janine SCHUURMAN , Paul PARREN
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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Patent Agency Ranking
公开(公告)号：US20170355767A1
公开(公告)日：2017-12-14
申请号：US15541594
申请日：2016-01-08
Applicant: GENMAB A/S
Inventor： Patrick ENGELBERTS , Esther BREIJ , Rik RADEMAKER , Isil ALTINTAS , David SATIJN , Sandra VERPLOEGEN , Riemke VAN DIJKHUIZEN RADERSMA , Edward VAN DEN BRINK , Janine SCHUURMAN , Paul PARREN
IPC: C07K16/28 , A61K39/395
CPC classification number: C07K16/2809 , A61K39/39558 , A61K2039/505 , C07K16/2887 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific targeting and T cell-mediated killing of cells that express CD20 is desired.
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公开(公告)号：US20220380464A1
公开(公告)日：2022-12-01
申请号：US17739923
申请日：2022-05-09
Applicant: GENMAB A/S
Inventor： Rik RADEMAKER , Isil ALTINTAS , Patrick ENGELBERTS , Janine SCHUURMAN , Paul PARREN
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US20210277133A1
公开(公告)日：2021-09-09
申请号：US17172700
申请日：2021-02-10
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK , Christian GRUNWITZ
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20210269541A1
公开(公告)日：2021-09-02
申请号：US17172698
申请日：2021-02-10
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK , Christian GRUNWITZ
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20200062853A1
公开(公告)日：2020-02-27
申请号：US16316534
申请日：2017-07-14
Applicant: GENMAB A/S , BIONTECH AG
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , G01N33/569 , A61K39/395
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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