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公开(公告)号：US20230257479A1
公开(公告)日：2023-08-17
申请号：US17642488
申请日：2020-09-11
Applicant: GENMAB A/S
Inventor： David SATIJN , Esther C.W. BREIJ , Bart E.C.G. DE GOEIJ , Kristel KEMPER , Patrick ENGELBERTS , Edward N. VAN DEN BRINK , Rik RADEMAKER , Dennis VERZIJL , Sjeng HORBACH , Paul PARREN , Reshma Abdulla RANGWALA , Sri GHATTA , Ruud BRAKENHOFF , Rieneke VAN DE VEN
CPC classification number: C07K16/30 , A61P1/00 , A61P35/00 , A61K2039/505
Abstract: The present invention relates to multispecific antibodies binding to 5T4 and CD3 for use in the treatment of cancer selected from the group consisting of esophageal cancer, Non-small Cell Lung Cancer (NSCLC) and Squamous Cell Carcinoma of the Head and Neck (SCCHN).
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公开(公告)号：US20230089969A1
公开(公告)日：2023-03-23
申请号：US17817033
申请日：2022-08-03
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US20230087745A1
公开(公告)日：2023-03-23
申请号：US17821837
申请日：2022-08-24
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK , Christian GRUNWITZ , Edward VAN DEN BRINK , Dennis VERZIJL
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20220324980A1
公开(公告)日：2022-10-13
申请号：US17695550
申请日：2022-03-15
Applicant: GENMAB A/S
Inventor： Louise KOOPMAN , Patrick ENGELBERTS , Dennis VERZIJL , Edward N. VAN DEN BRINK , Rik RADEMAKER , Sieto BOSGRA , Frederikke L. EGEROD , David SATIJN , Esther C. W BREIJ
Abstract: The present invention relates to antibodies binding to B7H4, including bispecific antibodies binding to B7H4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US20220033510A1
公开(公告)日：2022-02-03
申请号：US17360438
申请日：2021-06-28
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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Patent Agency Ranking
公开(公告)号：US20210369842A1
公开(公告)日：2021-12-02
申请号：US17289602
申请日：2019-11-06
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK
Abstract: The present invention relates to pharmaceutical formulations of binding agents and their use in medicine. In particular, the invention relates to pharmaceutical formulations of binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the pharmaceutical formulations of the invention and to methods for producing pharmaceutical formulations.
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公开(公告)号：US20220380464A1
公开(公告)日：2022-12-01
申请号：US17739923
申请日：2022-05-09
Applicant: GENMAB A/S
Inventor： Rik RADEMAKER , Isil ALTINTAS , Patrick ENGELBERTS , Janine SCHUURMAN , Paul PARREN
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US20210277133A1
公开(公告)日：2021-09-09
申请号：US17172700
申请日：2021-02-10
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK , Christian GRUNWITZ
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20210269541A1
公开(公告)日：2021-09-02
申请号：US17172698
申请日：2021-02-10
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK , Christian GRUNWITZ
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20200062853A1
公开(公告)日：2020-02-27
申请号：US16316534
申请日：2017-07-14
Applicant: GENMAB A/S , BIONTECH AG
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , G01N33/569 , A61K39/395
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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