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公开(公告)号：US20180265465A1
公开(公告)日：2018-09-20
申请号：US15988956
申请日：2018-05-24
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D207/16 , C07D277/06 , C07D413/14 , C07D413/12 , C07D401/10 , C07D471/08 , C07D401/12 , C07C235/54 , C07D405/10 , C07D403/14
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2103/74 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20190031607A1
公开(公告)日：2019-01-31
申请号：US16150070
申请日：2018-10-02
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian Salvatore SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D207/16 , C07C235/52 , C07D209/02 , C07D401/10 , C07D205/04 , C07D207/22 , C07D211/20 , C07C235/42 , C07D211/38 , C07D409/06 , C07D265/30 , C07D413/12 , C07D263/26 , C07C235/54 , C07D417/12 , C07D305/08 , C07D213/69 , C07D403/04 , C07D231/06 , C07D209/52 , C07D221/22 , C07D209/54 , C07D403/12 , C07D211/60 , C07D207/10 , C07D401/12 , C07D471/08 , C07D413/14 , C07D207/08 , C07D405/10 , C07D403/14 , C07D451/02 , C07D401/14 , C07D263/04 , C07D277/06
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20180346416A1
公开(公告)日：2018-12-06
申请号：US16057693
申请日：2018-08-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Christoph Martin DEHNHARDT , Sultan CHOWDHURY , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Brian Salvatore SAFINA , Daniel P. SUTHERLIN
IPC: C07C307/06 , C07D277/24 , C07D401/12 , C07D305/08 , C07D213/64 , C07D213/63 , C07D277/62 , C07D277/34 , C07D405/12 , C07D231/56 , C07D215/20 , C07D213/74 , C07D213/69 , C07D209/08 , C07D205/04 , C07D413/12 , C07D217/02
CPC classification number: C07C307/06 , C07C2601/04 , C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: The invention provides methods for treating pain using compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, ring D, R1, and RN have the meaning as described herein.
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公开(公告)号：US20190112264A1
公开(公告)日：2019-04-18
申请号：US16088417
申请日：2017-03-28
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Steven MCKERRALL , Daniel SUTHERLIN
IPC: C07C381/10 , C07D205/04 , C07D213/69 , C07D211/42 , C07D211/22 , C07D401/12 , A61P25/04
CPC classification number: C07C381/10 , A61P25/04 , C07D205/04 , C07D211/22 , C07D211/42 , C07D213/69 , C07D401/12
Abstract: The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, ring B, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20180291014A1
公开(公告)日：2018-10-11
申请号：US15939112
申请日：2018-03-28
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Phillipe BERGERON , Kristen BURFORD , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Abid HASAN , Kwong Wah LAI , Zhiguo LIU , Steven MCKERRALL , Teresa Phuongtram NGUYEN , Brian SAFINA , Daniel SUTHERLIN , Tao WANG
IPC: C07D417/12 , C07D417/14 , C07D401/12 , C07D405/14 , C07D491/107 , A61P17/04
Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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Patent Agency Ranking
公开(公告)号：US20150322002A1
公开(公告)日：2015-11-12
申请号：US14413218
申请日：2013-07-05
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Christoph Martin DEHNHARDT , Sultan CHOWDHURY , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Brian SAFINA , Daniel P. SUTHERLIN
IPC: C07C307/06 , C07D205/04 , C07D217/02 , C07D413/12 , C07D277/24 , C07D209/08 , C07D213/69 , C07D401/12
CPC classification number: C07C307/06 , C07C2601/04 , C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, ring D, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供具有通式（I）的新化合物及其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，环D，R1和RN具有如上所述的含义 和含有这些化合物的组合物和使用这些化合物和组合物的方法。
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公开(公告)号：US20210171516A1
公开(公告)日：2021-06-10
申请号：US17031348
申请日：2020-09-24
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Philippe BERGERON , Kristen BURFORD , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Abid HASAN , Kwong Wah LAI , Zhiguo LIU , Steven MCKERRALL , Teresa Phuongtram NGUYEN , Brian Salvatore SAFINA , Daniel SUTHERLIN , Tao WANG
IPC: C07D417/12 , C07D417/14 , A61P17/04 , C07D401/12 , C07D405/14 , C07D491/107
Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20210093618A1
公开(公告)日：2021-04-01
申请号：US16677487
申请日：2019-11-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian Salvatore SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: A61K31/445 , C07D295/26 , A61K31/4015 , C07D211/22 , C07D233/68 , C07D305/08 , C07D205/12 , A61K31/4523 , C07D405/12 , C07D413/06 , C07D451/02 , C07D405/04 , C07D211/54 , C07D403/12 , C07D487/08 , C07D237/08 , C07D205/04 , C07D211/32 , A61K31/4412 , A61K31/415 , C07D401/04 , A61K31/337 , A61K31/495 , C07D211/60 , A61K31/4545 , C07D403/04 , C07D413/12 , C07D401/12 , C07D265/30 , C07D417/06 , C07D451/06 , C07D211/42 , A61K31/397 , C07F7/08 , C07D211/96 , C07D241/04 , C07D401/06 , C07D453/02 , C07D207/12 , C07D295/155
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20210078947A1
公开(公告)日：2021-03-18
申请号：US16702286
申请日：2019-12-03
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian Salvatore SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20160009710A1
公开(公告)日：2016-01-14
申请号：US14772735
申请日：2014-03-14
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Paul Robert BICHLER , Sultan CHOWDHURY , Shannon Marie DECKER , Christopher Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Brian SAFINA , Tao SHENG , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D471/08 , C07D519/00
Abstract: The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供具有以下通式的化合物：[插入式（I）]（I）及其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，R1，R2，R3 ，R4和RN具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
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