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公开(公告)号：US07371774B2
公开(公告)日：2008-05-13
申请号：US10579996
申请日：2004-11-08
IPC分类号： A61K31/343 , A61K31/381 , C07D333/64 , C07D307/83
CPC分类号： C07D333/64 , C07D307/83
摘要： The invention relates to compounds of the general formula (I) below: in which R1, R2, R3, R4, R5, R6 and X are as defined in claim 1. These compounds can be used in the treatment of pathologies associated with insulin resistance syndrome.
摘要翻译： 本发明涉及以下通式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6和X如权利要求1中所定义。这些化合物可用于治疗与胰岛素抵抗相关的病理 综合征
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2.发明授权Antidiabetic compounds comprising benzofuran and benzothiophene derivatives 失效包含苯并呋喃和苯并噻吩衍生物的抗糖尿病化合物公开(公告)号：US07375130B2
公开(公告)日：2008-05-20
申请号：US10580033
申请日：2004-10-26
IPC分类号： A61K31/381 , C07D333/64
CPC分类号： A61K31/381 , A61K31/343 , C07D333/68 , C07D333/70
摘要： The invention relates to compounds of the general formula (I) below: in which R1, R2, R3, R4, R5, R6 and X are as defined in claim 1. These compounds can be used in the treatment of pathologies associated with insulin resistance syndrome.
摘要翻译： 本发明涉及以下通式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6和X如权利要求1中所定义。这些化合物可用于治疗与胰岛素抵抗相关的病理 综合征
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3.发明授权公开(公告)号：US07034021B2
公开(公告)日：2006-04-25
申请号：US10181223
申请日：2001-01-25
IPC分类号： C07D251/10 , A61K31/53 , A61P3/06 , A61P3/10
CPC分类号： A61K31/53 , A61K31/58 , C07D251/10 , C07D251/52 , C07D251/72
摘要： The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. Said compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome.
摘要翻译： 本发明涉及通式（I）的化合物，其中：R 1，R 2，R 3，R 4，R 5和R 6如权利要求1中所定义。所述化合物可用于治疗与胰岛素抵抗综合征相关的病理学。
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4.发明授权4-(1-piperazinyl) benzoic acid derivatives, process for preparing them and their therapeutic applications 失效4-（1-哌嗪基）苯甲酸衍生物，其制备方法及其治疗应用公开(公告)号：US06281215B1
公开(公告)日：2001-08-28
申请号：US09331155
申请日：1999-10-20
IPC分类号： A61K31495
CPC分类号： C07D295/15 , C07D215/08 , C07D307/52
摘要： New 4-(1-piperazinyl)benzoic acid derivatives of the formula (I) are described. Also described is methods for making these compounds and their use as therapeutic agents. In particular, the compounds find use in the treatment of diabetes.
摘要翻译： 描述了式（I）的新的4-（1-哌嗪基）苯甲酸衍生物。 还描述了制备这些化合物及其作为治疗剂的用途的方法。 特别地，这些化合物可用于治疗糖尿病。
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5.发明授权Phenylcarboxylic acid derivatives and use thereof for the treatment of diabetes 有权苯基羧酸衍生物及其用于治疗糖尿病的用途公开(公告)号：US07816397B2
公开(公告)日：2010-10-19
申请号：US11630892
申请日：2005-06-01
申请人： Gérard Moinet , Gérard Botton , Micheline Kergoat
发明人： Gérard Moinet , Gérard Botton , Micheline Kergoat
IPC分类号： C07C311/21 , C07C311/46 , C07C311/08 , C07C311/29 , C07C311/13 , C07C311/44 , C07C311/10 , C07D333/34 , A61P3/04 , A61P3/10
CPC分类号： C07C311/21 , C07C233/25 , C07C233/26 , C07C233/27 , C07C233/29 , C07C233/48 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/75 , C07C233/81 , C07C235/16 , C07C235/24 , C07C235/38 , C07C235/48 , C07C235/56 , C07C237/42 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/29 , C07C311/44 , C07C311/46 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D215/36 , C07D277/46 , C07D307/68 , C07D333/34 , C07D333/38 , C07D333/62
摘要： The invention relates to compounds of general formula (1): in which R1, R2, R3, R4, R5, A, B, D and E are as defined in Claim 1, and also to the preparation process therefor and the therapeutic use thereof. These compounds can be used in the treatment of pathologies associated with hyperglycaemia.
摘要翻译： 本发明涉及通式（1）的化合物：其中R 1，R 2，R 3，R 4，R 5，A，B，D和E如权利要求1所定义，以及其制备方法及其治疗用途 。 这些化合物可用于治疗与高血糖相关的病理学。
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6.发明授权公开(公告)号：US07727977B2
公开(公告)日：2010-06-01
申请号：US10541377
申请日：2003-12-18
申请人： Valerie Autier , Annick Arbellot De Vacqueur , Gérard Moinet , Dominique Mariais , Catherine Kargar , Micheline Kergoat
发明人： Valerie Autier , Annick Arbellot De Vacqueur , Gérard Moinet , Dominique Mariais , Catherine Kargar , Micheline Kergoat
IPC分类号： A61K31/33 , A61K31/194 , A61K31/235 , A61K31/426 , A61P3/10
CPC分类号： A61K45/06 , A61K31/00 , A61K31/06 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/22 , A61K31/235 , A61K31/426 , A61K31/55 , A61K2300/00
摘要： The present invention relates to the use of at least one compound with inhibitory activity on kynurenine 3-hydroxylase for the preparation of a medicament for the prevention and/or treatment of diabetes.
摘要翻译： 本发明涉及至少一种具有抑制活性的化合物对犬奈因宁3-羟化酶的用途，用于制备用于预防和/或治疗糖尿病的药物。
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7.发明授权Antidiabetic piperazine derivatives, processes for their preparation and compositions containing them 失效抗糖尿病哌嗪衍生物，其制备方法和含有它们的组合物公开(公告)号：US06376495B1
公开(公告)日：2002-04-23
申请号：US09744693
申请日：2001-01-29
IPC分类号： A61K31495
CPC分类号： C07D239/42 , C07D213/74 , C07D277/82 , C07D295/088
摘要： Piperazine derivatives of formula (I) wherein Z, X, n, Ar and i have the meanings defined herein are usefull in the treatment of pathologies associated with insulin-resistance syndrome.
摘要翻译： 式（I）的哌嗪衍生物其中Z，X，n，Ar和i具有本文定义的含义，可用于治疗与胰岛素抵抗综合征相关的病理学。
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8.发明授权(Aminoiminomethyl) amino) alkane-carboxamides and their applications in therapy 有权（（氨基亚氨基甲基）氨基）烷酰胺及其在治疗中的应用公开(公告)号：US06518458B1
公开(公告)日：2003-02-11
申请号：US09869957
申请日：2001-07-10
IPC分类号： C07C23305
CPC分类号： C07D213/75 , C07C279/14 , C07C2601/16 , C07D295/185
摘要： The invention to a pharmaceutical composition comprising as active principle a compound of general formula (I), in which R1, R2, R3, and A are as defined in claim 1. These compositions can be used in the treatment of pathologies associated with insulin resistance syndrome.
摘要翻译： 本发明涉及包含作为活性成分的通式（I）化合物的药物组合物，其中R 1，R 2，R 3和A如权利要求1所定义。这些组合物可用于治疗与胰岛素抵抗相关的病理学 综合征
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公开(公告)号：US06437143B1
公开(公告)日：2002-08-20
申请号：US09202076
申请日：1998-12-07
申请人： Gérard Moinet , Gérard Botton , Etienne Prugnard , Liliane Doare , Micheline Kergoat , Didier Mesangeau
发明人： Gérard Moinet , Gérard Botton , Etienne Prugnard , Liliane Doare , Micheline Kergoat , Didier Mesangeau
IPC分类号： C07D27734
摘要： The present invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The subject of the present invention is more precisely new 5-phenoxyalkyl-2,4-thiazolidinediones of general formula I: in which A represents a linear or branched alkylene group comprising from 2 to 16 carbon atoms D represents a homo- or heterocarbon mono-, di- or tricyclic aromatic structure which may include one or more heteroatoms X represents the substituent of the aromatic structure and is as defined in Claim 1 n is an integer ranging from 1 to 3 with the proviso that if A represents a butyl radical, does not represent the 4-chlorophenyl group. The invention also relates to the tautomeric forms, to the enantiomers, diastereoisomers and epimers of the compounds of general formula I, in free or salified form. The present invention also relates to the processes for producing the compounds of general formula I, their use as antidiabetic agents, and in the treatment of the metabolic syndrome of insulin resistance, as well as the pharmaceutical compositions which contain the compounds of general formula I.
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公开(公告)号：US08791115B2
公开(公告)日：2014-07-29
申请号：US12160664
申请日：2006-12-18
申请人： Gérard Moinet , Daniel Cravo , Didier Mesangeau
发明人： Gérard Moinet , Daniel Cravo , Didier Mesangeau
IPC分类号： A61K31/53 , A61K31/155
CPC分类号： A61K31/53 , A61K31/422 , A61K31/4439 , A61K2300/00
摘要： The present invention relates to combinations of triazine derivatives and of insulin sensitizers.
摘要翻译： 本发明涉及三嗪衍生物和胰岛素敏化剂的组合。
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