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1.发明授权Methods and compositions for inhibition of immune responses and autoimmunity 有权用于抑制免疫应答和自身免疫的方法和组合物公开(公告)号：US08962579B2
公开(公告)日：2015-02-24
申请号：US12767692
申请日：2010-04-26
Applicant: Franck Barrat , Robert L. Coffman , Tracy Matray , Cristiana Guiducci
Inventor： Franck Barrat , Robert L. Coffman , Tracy Matray , Cristiana Guiducci
IPC: A61K31/711 , C12N15/117 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K31/713
CPC classification number: C12N15/117 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K31/713 , A61K45/06 , C12N2310/17 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/331 , C12N2310/3341 , C12N2310/336 , C12N2310/345 , C12N2310/3521
Abstract: The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence. It also relates to the administration of the immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence to regulate an immune response.
Abstract translation: 本申请涉及免疫调节多核苷酸和/或免疫调节化合物与其它治疗剂组合的用途。 本申请还涉及包含修饰的免疫调节序列的免疫调节多核苷酸和/或免疫调节化合物。 它还涉及免疫调节多核苷酸和/或免疫调节化合物的施用，其包含修饰的免疫调节序列以调节免疫应答。
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公开(公告)号：US20130156814A1
公开(公告)日：2013-06-20
申请号：US13704978
申请日：2011-06-16
Applicant: Franck Barrat , Robert L. Coffman , Cristiana Guiducci
Inventor： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
IPC: C12N15/117 , A61K31/573 , A61K31/7125
CPC classification number: C12N15/117 , A61K31/573 , A61K31/7125 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2320/30 , C12N2320/31 , Y02A50/411 , C12N2310/3521
Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.
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公开(公告)号：US08940310B2
公开(公告)日：2015-01-27
申请号：US13704978
申请日：2011-06-16
Applicant: Franck Barrat , Robert L. Coffman , Cristiana Guiducci
Inventor： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
IPC: A61K31/7125 , A01N43/04 , C12N15/117
CPC classification number: C12N15/117 , A61K31/573 , A61K31/7125 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2320/30 , C12N2320/31 , Y02A50/411 , C12N2310/3521
Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.
Abstract translation: 本申请涉及调节包含TLR7和/或TLR9抑制剂的免疫应答的组合物和方法，例如免疫调节多核苷酸和/或免疫调节化合物。 本申请还涉及用于预测和/或确定疾病对包括TLR7和/或TLR9抑制剂的治疗反应性的组合物和方法。
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公开(公告)号：US09063123B2
公开(公告)日：2015-06-23
申请号：US13434805
申请日：2012-03-29
Applicant: Franck Barrat , Robert L. Coffman , Cristiana Guiducci
Inventor： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
IPC: C12N5/16 , G01N33/50 , A01K67/027 , C07K14/705
CPC classification number: G01N33/5073 , A01K67/0271 , A01K67/0278 , A01K2217/052 , A01K2227/105 , A01K2267/0387 , C07K14/705 , C07K14/70596 , C12N5/0647 , C12N2510/00 , G01N33/502 , G01N33/5023 , G01N33/5038
Abstract: Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic s and methods of use thereof.
Abstract translation: 本文提供了表达转基因的人Toll样受体8（TLR8）及其使用方法。
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Patent Agency Ranking
公开(公告)号：US20120252051A1
公开(公告)日：2012-10-04
申请号：US13434805
申请日：2012-03-29
Applicant: Franck Barrat , Robert L. Coffman , Cristiana Guiducci
Inventor： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
IPC: A01K67/027 , C12Q1/02 , C12N5/10
CPC classification number: G01N33/5073 , A01K67/0271 , A01K67/0278 , A01K2217/052 , A01K2227/105 , A01K2267/0387 , C07K14/705 , C07K14/70596 , C12N5/0647 , C12N2510/00 , G01N33/502 , G01N33/5023 , G01N33/5038
Abstract: Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic animals and methods of use thereof.
Abstract translation: 本文提供了表达转基因动物的人Toll样受体8（TLR8）及其使用方法。
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公开(公告)号：US20090131512A1
公开(公告)日：2009-05-21
申请号：US12290654
申请日：2008-10-30
Applicant: Franck Barrat , Cristiana Guiducci , Vassili Soumelis
Inventor： Franck Barrat , Cristiana Guiducci , Vassili Soumelis
IPC: A61K31/366 , A61P37/00
CPC classification number: A61K31/366 , A61K31/00 , A61K31/381 , A61K31/52 , A61K31/5377
Abstract: The invention provides methods for decreasing type I IFN production by human plasmacytoid dendritic cells in response to TLR activation.
Abstract translation: 本发明提供了减少人浆细胞样树突状细胞响应TLR活化的I型IFN产生的方法。
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7.发明授权Methods and compositions for inhibition of innate immune responses and autoimmunity 有权用于抑制先天免疫应答和自身免疫的方法和组合物公开(公告)号：US08759305B2
公开(公告)日：2014-06-24
申请号：US11212297
申请日：2005-08-24
Applicant: Franck Barrat , Robert L. Coffman
Inventor： Franck Barrat , Robert L. Coffman
CPC classification number: C07K14/705 , C12N15/117 , C12N2310/17 , C12N2310/318 , C12N2310/3183 , C12N2310/336
Abstract: The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.
Abstract translation: 本发明提供免疫调节多核苷酸和使用免疫调节多核苷酸免疫调节个体的方法。
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8.发明申请公开(公告)号：US20060193869A1
公开(公告)日：2006-08-31
申请号：US11303588
申请日：2005-12-16
Applicant: Franck Barrat , Robert Coffman
Inventor： Franck Barrat , Robert Coffman
CPC classification number: A61K39/0008 , A61K2039/6025 , C07K14/47
Abstract: The invention provides non-immunostimulatory polynucleotide antigen conjugates and methods for treating unwanted immune reactions in individuals using the non-immunostimulatory polynucleotide antigen conjugates.
Abstract translation: 本发明提供非免疫刺激性多核苷酸抗原缀合物和使用非免疫刺激性多核苷酸抗原缀合物治疗个体中不想要的免疫反应的方法。
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9.发明申请Methods and compositions for inhibition of innate immune responses and autoimmunity 有权用于抑制先天免疫应答和自身免疫的方法和组合物公开(公告)号：US20070238678A1
公开(公告)日：2007-10-11
申请号：US11212297
申请日：2005-08-24
Applicant: Franck Barrat , Robert Coffman
Inventor： Franck Barrat , Robert Coffman
CPC classification number: C07K14/705 , C12N15/117 , C12N2310/17 , C12N2310/318 , C12N2310/3183 , C12N2310/336
Abstract: The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.
Abstract translation: 本发明提供免疫调节多核苷酸和使用免疫调节多核苷酸免疫调节个体的方法。
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