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1.发明申请公开(公告)号：US20060193869A1
公开(公告)日：2006-08-31
申请号：US11303588
申请日：2005-12-16
Applicant: Franck Barrat , Robert Coffman
Inventor： Franck Barrat , Robert Coffman
CPC classification number: A61K39/0008 , A61K2039/6025 , C07K14/47
Abstract: The invention provides non-immunostimulatory polynucleotide antigen conjugates and methods for treating unwanted immune reactions in individuals using the non-immunostimulatory polynucleotide antigen conjugates.
Abstract translation: 本发明提供非免疫刺激性多核苷酸抗原缀合物和使用非免疫刺激性多核苷酸抗原缀合物治疗个体中不想要的免疫反应的方法。
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2.发明申请Methods and compositions for inhibition of innate immune responses and autoimmunity 有权用于抑制先天免疫应答和自身免疫的方法和组合物公开(公告)号：US20070238678A1
公开(公告)日：2007-10-11
申请号：US11212297
申请日：2005-08-24
Applicant: Franck Barrat , Robert Coffman
Inventor： Franck Barrat , Robert Coffman
CPC classification number: C07K14/705 , C12N15/117 , C12N2310/17 , C12N2310/318 , C12N2310/3183 , C12N2310/336
Abstract: The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.
Abstract translation: 本发明提供免疫调节多核苷酸和使用免疫调节多核苷酸免疫调节个体的方法。
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公开(公告)号：USD427752S
公开(公告)日：2000-07-11
申请号：US112584
申请日：1999-10-19
Applicant: Robert Coffman , Glen Williams
Designer： Robert Coffman , Glen Williams
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4.发明授权IL-4 and IL-10 to downregulate delayed-type hypersensitivity and cytokine expresion by T-cells 失效IL-4和IL-10下调T细胞的延迟型超敏反应和细胞因子表达
公开(公告)号：US5601815A
公开(公告)日：1997-02-11
申请号：US531994
申请日：1995-09-21
Applicant: Fiona Powrie , Robert Coffman
Inventor： Fiona Powrie , Robert Coffman
CPC classification number: C07K16/247 , A61K38/2026 , A61K38/2066
Abstract: The invention provides in vivo methods for potentiating IL-10 mediated inhibition of cytokine production by T cells in a mammal. The method comprises co-administering to the mammal an effective amount of IL-4 and IL-10, preferably intravascularly.
Abstract translation: 本发明提供用于增强IL-10介导的抑制哺乳动物中T细胞产生细胞因子的体内方法。 该方法包括向哺乳动物施用有效量的IL-4和IL-10，优选血管内给药。
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