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    METHOD FOR MANUFACTURING A COMPOSITE SENSOR
    2.
    发明公开
    METHOD FOR MANUFACTURING A COMPOSITE SENSOR 审中-公开

    公开(公告)号：US20240043783A1

    公开(公告)日：2024-02-08

    申请号：US18490598

    申请日：2023-10-19

    申请人： Finesse Solutions, Inc.

    发明人： Mark Selker ,  Barbara Paldus ,  Timothy Johnston

    IPC分类号： C12M1/34 ,  C12M1/00 ,  C12M3/06

    CPC分类号： C12M41/00 ,  C12M23/14 ,  C12M23/28 ,  C12M27/16 ,  G01N21/359

    摘要： A method of manufacturing a composite sensor assembly includes: providing a port including a high surface tension thermoplastic, the port having a hollow tubular portion and a base having a polymer surface; fusing the polymer surface of the port to a wall of a polymeric bioprocess vessel so that the port communicates with an opening in the wall; and retaining a sensor unit within the hollow tubular portion of the port with an adhesive, at least a portion of the sensor unit being polymeric, wherein the port provides the sensor unit access to an interior of the polymeric bioprocess vessel.

    Method of Carrying Out a Bioreaction with Multiple Coupled Vessels
    4.
    发明申请
    Method of Carrying Out a Bioreaction with Multiple Coupled Vessels 有权

    公开(公告)号：US20220169964A1

    公开(公告)日：2022-06-02

    申请号：US17677517

    申请日：2022-02-22

    申请人： Finesse Solutions, Inc.

    发明人： Barbara Paldus ,  Mark Selker

    IPC分类号： C12M1/00 ,  C12M3/00 ,  C12M1/06 ,  C12M1/34 ,  C12M3/06 ,  C12M1/12 ,  C12M1/02 ,  C12M1/26

    摘要： A method of carrying out a bioreaction in a multivessel bioreactor system may include flowing a culture medium at an initial flow rate through one or more fluidic paths between a master vessel and one or more slave vessels, detecting a first culture medium parameter value in the master vessel or the slave vessels, transmitting the first culture medium parameter value to a control system, determining an adjusted flow rate of the culture medium at the control system based on the first culture medium parameter value, and controlling a bidirectional fluid transfer device with the control system to adjust the flow rate of the culture medium through the one or more fluidic paths. The control system may adjust the flow rate of the culture medium to maintain a substantially uniform value of the first culture medium parameter value in the master vessel or the one or more slave vessels.

    Bioreactor with multiple coupled vessels
    5.
    发明授权
    Bioreactor with multiple coupled vessels 有权

    公开(公告)号：US11292999B2

    公开(公告)日：2022-04-05

    申请号：US15427613

    申请日：2017-02-08

    申请人： Finesse Solutions, Inc.

    发明人： Barbara Paldus ,  Mark Selker

    IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M1/02 ,  C12M1/26 ,  C12M1/34 ,  C12M3/00 ,  C12M1/06 ,  C12M3/06

    摘要： A bioreactor system may include (a) two or more fluidically coupled vessels configured to collectively carry out a bioreaction; (b) one or more fluidic paths coupling the two or more vessels to one another, where the fluidic paths are configured to provide flow of culture medium between the two or more vessels; (c) one or more fluid transfer devices along at least some of the one or more fluidic paths; and (d) a control system. The control system may be configured to (i) read or receive values of one or more parameters characterizing the culture medium in one or more of the vessels, and (ii) use the values to determine an adjusted flow rate in at least one of the fluidic paths to maintain substantially uniform values of the one or more parameters in the culture medium from vessel-to-vessel among the two or more vessels.

    Method for Manufacturing a Composite Sensor
    7.
    发明申请
    Method for Manufacturing a Composite Sensor 有权

    公开(公告)号：US20210403852A1

    公开(公告)日：2021-12-30

    申请号：US17370390

    申请日：2021-07-08

    申请人： Finesse Solutions, Inc.

    发明人： Mark Selker ,  Barbara Paldus ,  Timothy Johnston

    IPC分类号： C12M1/34 ,  C12M1/00 ,  C12M3/06

    摘要： A method of manufacturing a composite sensor assembly includes: providing a port including a high surface tension thermoplastic, the port having a hollow tubular portion and a base having a polymer surface; fusing the polymer surface of the port to a wall of a polymeric bioprocess vessel so that the port communicates with an opening in the wall; and retaining a sensor unit within the hollow tubular portion of the port with an adhesive, at least a portion of the sensor unit being polymeric, wherein the port provides the sensor unit access to an interior of the polymeric bioprocess vessel.

    VIRTUAL TRANSMITTER FOR BIOREACTOR AUTOMATION SYSTEM
    8.
    发明申请
    VIRTUAL TRANSMITTER FOR BIOREACTOR AUTOMATION SYSTEM 审中-公开

    公开(公告)号：US20190258236A1

    公开(公告)日：2019-08-22

    申请号：US16218707

    申请日：2018-12-13

    申请人： Finesse Solutions, Inc.

    发明人： Mark Selker ,  Barbara Paldus

    IPC分类号： G05B23/02 ,  C12M1/36

    摘要： The present set of embodiments relate to an environmental condition monitoring and control system employing a software based virtual transmitter for a bioreactor or mixer. The system includes a probe for measuring a condition in a bioreactor that can generate a signal. Measured conditions may include pH, DO, temperature, and pressure. The signal can travel to an electronic card capable of converting the signal from analog to digital and the card can then send the converted signal to a digital controller. The condition monitoring and control system eliminates hardware redundancies and increases versatility by then displaying the converted signal in a software-based virtual transmitter on a non-dedicated human machine interface.

    Method for Quantifying Solutions Comprised of Multiple Analytes
    10.
    发明申请
    Method for Quantifying Solutions Comprised of Multiple Analytes 有权

    公开(公告)号：US20220187128A1

    公开(公告)日：2022-06-16

    申请号：US17685595

    申请日：2022-03-03

    申请人： Finesse Solutions, Inc.

    发明人： Mark Selker ,  Barbara Paldus

    IPC分类号： G01J3/44 ,  G01J3/02 ,  G01N21/65 ,  G02B6/02

    摘要： A method of determining the identity and concentration of a target analyte present in a biological sample includes: introducing a first target analyte into a hollow core of an optical fiber; introducing a first reference calibrant into the hollow core of the optical fiber; transmitting light from a laser light source through the hollow core of the optical fiber and the first target analyte to generate a first Raman anti-Stokes analyte emission corresponding to the first target analyte; receiving the first Raman anti-Stokes analyte emission at a spectral analysis system optically coupled to the optical fiber; and deriving Raman anti-Stokes spectral peaks or spectra of the first target analyte at the spectral analysis system based on the first Raman anti-Stokes analyte emission.