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公开(公告)号：US20170043080A1
公开(公告)日：2017-02-16
申请号：US15337418
申请日：2016-10-28
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
CPC classification number: A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
Abstract: Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
Abstract translation: 提供离心系统和方法用于将血液分离成其组成部分。 离心机的内壁和外壁各自包括朝向另一壁延伸的突起。 分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口 的房间。 随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。 第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。
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公开(公告)号：US09119914B2
公开(公告)日：2015-09-01
申请号：US13778474
申请日：2013-02-27
Applicant: Fenwal, Inc.
Inventor： Lan T. Nguyen , John T. Foley , Jonathan Prendergast , Matthew Schoonover
CPC classification number: A61M1/16 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3609 , A61M1/3643 , A61M1/3644 , A61M2202/0429 , A61M2205/12 , A61M2205/50 , A61M2240/00
Abstract: A method is disclosed for priming a kit for use in a therapeutic apheresis procedure with previously-collected blood prior to flowing the patient's whole blood into the inlet line of the kit, as part of a procedure in which a selected blood component is separated from a patient's whole blood, and replaced with a previously-collected blood component. The operator enters into the controller of the separation device the hematocrit value of the previously-collected blood. Then, in response to prompts by the controller, the operator enters a target hematocrit value for the previously-collected blood and an identification of the portion of the kit to be primed. The identified portion of the kit is automatically primed with the previously-collected blood. The patient is then connected to the inlet line of the kit in response to a prompt from the controller and the therapeutic procedure is commenced.
Abstract translation: 公开了一种用于在将患者的全血流入试剂盒的入口管线之前用先前收集的血液引发用于治疗性分离术的试剂盒的方法，作为将选择的血液成分与 患者的全血，并用以前收集的血液成分代替。 操作者将分离装置的控制器输入先前收集的血液的血细胞比容值。 然后，响应于控制器的提示，操作者输入先前收集的血液的目标血细胞比容值和待引发的试剂盒的部分的标识。 试剂盒的识别部分会自动使用以前收集的血液进行预处理。 然后响应于来自控制器的提示将患者连接到试剂盒的入口管线，并且治疗程序开始。
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3.发明授权公开(公告)号：US11938259B2
公开(公告)日：2024-03-26
申请号：US16529901
申请日：2019-08-02
Applicant: Fenwal, Inc.
Inventor： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C Case
IPC: A61M1/36
CPC classification number: A61M1/362 , A61M1/362227 , A61M1/36224 , A61M1/36225 , A61M1/362261 , A61M1/362265 , A61M1/3639 , A61M1/3663 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M1/362266
Abstract: Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.
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4.发明申请SYSTEMS AND METHODS FOR ACHIEVING TARGET POST-PROCEDURE FRACTION OF CELLS REMAINING, HEMATOCRIT, AND BLOOD VOLUME DURING A THERAPEUTIC RED BLOOD CELL EXCHANGE PROCEDURE WITH OPTIONAL ISOVOLEMIC HEMODILUTION 有权在治疗性红血球细胞交换程序期间用于实现可选的ISOVOLEMIC HEMODILUTION的实现靶细胞的剩余，HEMATOCRIT和血液体积的目标后续程序分类的系统和方法公开(公告)号：US20160296688A1
公开(公告)日：2016-10-13
申请号：US15184492
申请日：2016-06-16
Applicant: Fenwal, Inc.
Inventor： Daniel R. Boggs , Kyungyoon Min , Lan T. Nguyen , John T. Foley , Brian C. Case
CPC classification number: A61M1/3455 , A61M1/342 , A61M1/3437 , A61M1/3458 , A61M1/3496 , A61M1/3672 , A61M1/38 , A61M1/385 , A61M2205/3334 , A61M2205/505 , A61M2205/52 , A61M2230/005 , A61M2230/207 , G06F19/00
Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
Abstract translation: 公开了用于进行治疗性红细胞交换程序的系统和方法。 一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。 分离器与第一流路连通，用于从血浆中分离至少红细胞。 第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。 流量控制器与流动路径相关联，以控制流动路径之间的流体连通。 控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。
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5.发明申请公开(公告)号：US20190351126A1
公开(公告)日：2019-11-21
申请号：US16529901
申请日：2019-08-02
Applicant: Fenwal, Inc.
Inventor： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C. Case
IPC: A61M1/36
Abstract: Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.
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Patent Agency Ranking
公开(公告)号：US09943638B2
公开(公告)日：2018-04-17
申请号：US15337418
申请日：2016-10-28
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
CPC classification number: A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
Abstract: Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
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公开(公告)号：US20160114339A1
公开(公告)日：2016-04-28
申请号：US14524513
申请日：2014-10-27
Applicant: Fenwal, Inc.
Inventor： Lan T. Nguyen , Jonathan Prendergast , John T. Foley
CPC classification number: B04B11/04 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2205/331 , B04B5/0442 , B04B13/00 , B04B2013/006
Abstract: Systems and methods are provided for improving the flow rate of plasma being removed from a blood separation chamber during a blood separation procedure. The system includes a blood separation chamber in which plasma is separated from cellular blood components and an outlet line for removing the separated plasma from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the separated plasma in the outlet line, with each optical sensor assembly checking for the presence of cellular components in the separated plasma. If the primary optical sensor assembly detects such a condition while the secondary optical sensor assembly does not, then a controller may take steps to resolve the conflict and continue the procedure.
Abstract translation: 提供了系统和方法，用于改善血液分离过程中从血液分离室中除去的血浆的流速。 该系统包括：血液分离室，其中等离子体与细胞血液成分分离，以及用于从血液分离室除去分离的血浆的出口管线。 主要的光学传感器组件与血液分离室相关联，以直接监测血液分离室的内部。 第二光学传感器组件与出口管线相关联，以监测出口管线中的分离的等离子体，每个光学传感器组件检查分离的等离子体中的细胞组分的存在。 如果主光学传感器组件在次级光学传感器组件没有检测到这种状态时，则控制器可以采取步骤来解决冲突并继续该过程。
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公开(公告)号：US09962478B2
公开(公告)日：2018-05-08
申请号：US15184492
申请日：2016-06-16
Applicant: Fenwal, Inc.
Inventor： Daniel R. Boggs , Kyungyoon Min , Lan T. Nguyen , John T. Foley , Brian C. Case
CPC classification number: A61M1/3455 , A61M1/342 , A61M1/3437 , A61M1/3458 , A61M1/3496 , A61M1/3672 , A61M1/38 , A61M1/385 , A61M2205/3334 , A61M2205/505 , A61M2205/52 , A61M2230/005 , A61M2230/207 , G06F19/00
Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
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9.发明授权公开(公告)号：US09895700B2
公开(公告)日：2018-02-20
申请号：US14524513
申请日：2014-10-27
Applicant: Fenwal, Inc.
Inventor： Lan T. Nguyen , Jonathan Prendergast , John T. Foley
CPC classification number: B04B11/04 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2205/331 , B04B5/0442 , B04B13/00 , B04B2013/006
Abstract: Systems and methods are provided for improving the flow rate of plasma being removed from a blood separation chamber during a blood separation procedure. The system includes a blood separation chamber in which plasma is separated from cellular blood components and an outlet line for removing the separated plasma from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the separated plasma in the outlet line, with each optical sensor assembly checking for the presence of cellular components in the separated plasma. If the primary optical sensor assembly detects such a condition while the secondary optical sensor assembly does not, then a controller may take steps to resolve the conflict and continue the procedure.
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10.发明授权Systems and methods for achieving target post-procedure fraction of cells remaining, hematocrit, and blood volume during a therapeutic red blood cell exchange procedure with optional isovolemic hemodilution 有权用于在治疗性红细胞交换程序期间实现目标细胞残留的系统和方法，血细胞比容和血容量与任选的异构体血液稀释公开(公告)号：US09393359B2
公开(公告)日：2016-07-19
申请号：US13840113
申请日：2013-03-15
Applicant: Fenwal, Inc.
Inventor： Daniel R. Boggs , Kyungyoon Min , Lan T. Nguyen , John T. Foley , Brian Case
CPC classification number: A61M1/3455 , A61M1/342 , A61M1/3437 , A61M1/3458 , A61M1/3496 , A61M1/3672 , A61M1/38 , A61M1/385 , A61M2205/3334 , A61M2205/505 , A61M2205/52 , A61M2230/005 , A61M2230/207 , G06F19/00
Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
Abstract translation: 公开了用于进行治疗性红细胞交换程序的系统和方法。 一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。 分离器与第一流路连通，用于从血浆中分离至少红细胞。 第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。 流量控制器与流动路径相关联，以控制流动路径之间的流体连通。 控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。
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