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    Injectable dendrimer hydrogel nanoparticles
    3.
    发明授权
    Injectable dendrimer hydrogel nanoparticles 有权
    注射树枝状大分子水凝胶纳米粒子

    公开(公告)号：US09526794B2

    公开(公告)日：2016-12-27

    申请号：US13636715

    申请日：2011-03-31

    申请人： Kannan Rangaramanujam ,  Sujatha Kannan ,  Roberto Romero ,  Raghavendra Navath ,  Anupa Menjoge

    发明人： Kannan Rangaramanujam ,  Sujatha Kannan ,  Roberto Romero ,  Raghavendra Navath ,  Anupa Menjoge

    IPC分类号： A61K47/48 ,  C08L79/02 ,  C08G73/02

    CPC分类号： A61K47/48207 ,  A61K9/0019 ,  A61K9/0051 ,  A61K31/43 ,  A61K47/595 ,  A61K47/6903 ,  C08G73/028 ,  C08L79/02

    摘要： The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel disclosed in the present invention is formed as small crosslinked particles in the size range 25 nm to 10 μm and is suitable for injectable delivery of hydrogel to any of the body orifices, tissues by intramuscular or subcutaneous route and ocular delivery for the purpose of therapeutic treatment and imaging.

    摘要翻译： 本发明公开了具有5nm至10μm尺寸范围内的交联纳米珠或颗粒形式的可注射水凝胶，其包含具有不对称外周端基的PAMAM树枝状聚合物，使得端基中的一个参与水凝胶的形成，而另一个 涉及药物或成像剂的结合及其制备方法。 所述凝胶通过PAMAM树枝状聚合物与不对称端基与其它聚合物的反应形成，其中另一种聚合物选自具有官能化端基的直链，支链，超支化或星形聚合物。 具有不对称端基的PAMAM树枝状聚合物由使用氨基酸或其修饰形式修饰的具有对称端基的第2代和更高级PAMAM树枝状聚合物组成。 本发明中公开的凝胶形成为尺寸范围为25nm至10μm的小交联颗粒，并且适用于通过肌肉内或皮下途径将水凝胶注射到任何身体孔，组织中，目的是为了 治疗和成像。