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    Single variable domain antibodies against OX40L, constructs and therapeutic use
    4.
    发明授权
    Single variable domain antibodies against OX40L, constructs and therapeutic use 有权
    针对OX40L的单可变结构域抗体，构建体和治疗用途

    公开(公告)号：US08962807B2

    公开(公告)日：2015-02-24

    申请号：US13515876

    申请日：2010-12-14

    申请人： Frank Verdonck ,  Sigrid Cornelis ,  Stephanie Staelens

    发明人： Frank Verdonck ,  Sigrid Cornelis ,  Stephanie Staelens

    IPC分类号： C07K16/28 ,  A61K39/00

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/2875 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/31 ,  G01N33/6845 ,  G01N33/6854 ,  Y02A50/41 ,  Y02A50/412

    摘要： The present invention relates to immunoglobulin single variable domain sequences that are directed against (as defined herein) OX40L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such immunoglobulin single variable domain sequences. In particular these immunoglobulin single variable domain sequences can block binding of OX40L to OX40. The immunoglobulin single variable domains, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of inflammatory disease and/or disorder such as e.g. asthma, allergic asthma, chronic colitis, Crohn's disease, inflammatory bowel disease, and/or arthrosclerosis.

    摘要翻译： 本发明涉及针对（如本文定义）OX40L的免疫球蛋白单可变结构域序列以及包含或基本上由一个或多个这样的免疫球蛋白单可变结构域组成的化合物或构建体，特别是蛋白质和多肽， 序列。 特别地，这些免疫球蛋白单可变结构域序列可以阻断OX40L与OX40的结合。 免疫球蛋白单可变结构域，化合物和构建体可用于预防，治疗或诊断目的，例如用于治疗炎性疾病和/或病症，例如， 哮喘，过敏性哮喘，慢性结肠炎，克罗恩病，炎性肠病和/或关节动脉硬化。

    TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    5.
    发明申请
    TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
    涉及免疫球蛋白单个可变区域的测定中预测，检测和降低相关蛋白质干扰的技术

    公开(公告)号：US20140199295A1

    公开(公告)日：2014-07-17

    申请号：US14128681

    申请日：2012-06-25

    申请人： Judith Baumeister ,  Marie-Paule Lucienne Armanda Bouche ,  Carlo Boutton ,  Marie-Ange Buyse ,  Veerle Snoeck ,  Stephanie Staelens

    发明人： Judith Baumeister ,  Marie-Paule Lucienne Armanda Bouche ,  Carlo Boutton ,  Marie-Ange Buyse ,  Veerle Snoeck ,  Stephanie Staelens

    IPC分类号： C07K16/00

    CPC分类号： C07K16/28 ,  C07K16/00 ,  C07K16/4283 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2317/94 ,  C07K2319/30 ,  G01N33/6854

    摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

    摘要翻译： 本发明提供并且在某些特定但非限制性方面涉及：可用于预测给定ISV是否将如本文所述受到蛋白质干扰和/或产生（特异性）信号的测定法 测定（例如在ADA免疫测定中）。 这样的预测测定可以例如用于测试给定的ISV是否可能具有引起这种蛋白质干扰和/或这种信号的倾向; 选择不是或不太容易发生蛋白质干扰的ISV或给出这样的信号; 作为可用于测试对ISV的某些修改（完全或部分）是否降低其引起这种干扰或这种信号的趋势的测定或测试; 和/或作为可用于指导ISV的修饰或改进的测定或测试，以便减少引起这种蛋白质干扰或信号的趋势; - 用于修饰和/或改善ISV的方法以消除或减少其引起这种蛋白质干扰或这种信号的倾向; - 可以引入到ISV中的改变，其去除或减少其引起这种蛋白质干扰或这种信号的趋势; 已经特别选择的ISV（例如，使用本文所述的测定）具有没有或低（呃）/降低的趋势导致这种蛋白质干扰或这种信号; 修饰和/或改进的ISV，其没有或低（呃）/降低的趋势引起这种蛋白质干扰或这种信号。