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公开(公告)号：USD282037S
公开(公告)日：1986-01-07
申请号：US478206
申请日：1983-03-23
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公开(公告)号：US4536906A
公开(公告)日：1985-08-27
申请号：US489386
申请日：1983-04-28
CPC分类号： A47C27/20 , A47C21/046 , A47C27/148
摘要： A mattress for small children has a removable foam insert which fits in an aperture cut in the head portion of a foam mattress body. The insert has a plurality of perforations extending from its top face to its bottom face which reduce the risk of suffocation, the perforations being grouped towards the head of the mattress for optimum positioning beneath the child's head. To ensure that a replacement insert, when the former insert is soiled and requires washing, is fitted in the correct orientation, each insert has a key portion projecting from one edge for interlocking with a correspondingly shaped recess in a side wall of the aperture.
摘要翻译： 用于小孩子的床垫具有可拆卸的泡沫插入物，其适于在泡沫床垫主体的头部中切割的孔。 插入物具有从其顶面延伸到其底面的多个穿孔，其减少了窒息的风险，将穿孔分组到床垫的头部以便最佳地定位在儿童头部下方。 为了确保更换的插入物在前一个插入物被污染并需要洗涤时以正确的方向安装，每个插入件具有从一个边缘突出的键部分，用于与孔的侧壁中的相应形状的凹部互锁。
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公开(公告)号：US20140271782A1
公开(公告)日：2014-09-18
申请号：US13840810
申请日：2013-03-15
申请人： Michael W. Fountain
发明人： Michael W. Fountain
CPC分类号： C12G3/00 , A23G9/32 , A23G9/48 , A23G9/485 , A23L33/10 , A23P10/35 , A23V2002/00 , A61K9/51 , A61K9/5123 , A61K9/5192 , C12G3/04
摘要： A method for preparing ethanol-containing nanolipid particles, which can be used in food products, frozen desserts, or beverages. The method comprises nanolipidic vehicles in which ethanol-containing substances are encapsulated, said ethanol-containing nanolipidic vehicles can be combined with food products, desserts or beverage ingredients including those that are subsequently frozen, The food product, dessert or beverage can remain in a frozen state during consumption by an individual. A composition comprising ethanol-containing nanolipid particles, which can be used in food products, frozen desserts, or beverages.
摘要翻译： 一种制备含乙醇的纳脂脂颗粒的方法，可用于食品，冷冻甜点或饮料。 该方法包括其中包含含乙醇的物质的纳摩脂载体，所述含乙醇的纳摩脂载体可以与食品，甜点或饮料成分组合，包括随后冷冻的那些，食品，甜品或饮料可以保留在冷冻 在一个人的消费状态。 包含可用于食品，冷冻甜品或饮料的含乙醇的纳脂脂颗粒的组合物。
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公开(公告)号：US5578320A
公开(公告)日：1996-11-26
申请号：US22819
申请日：1993-02-24
申请人： Andrew S. Janoff , Pieter R. Cullis , Marcel B. Bally , Michael W. Fountain , Richard S. Ginsberg , Michael J. Hope , Thomas D. Madden , Hugh P. Schieren , Regina L. Jablonski
发明人： Andrew S. Janoff , Pieter R. Cullis , Marcel B. Bally , Michael W. Fountain , Richard S. Ginsberg , Michael J. Hope , Thomas D. Madden , Hugh P. Schieren , Regina L. Jablonski
IPC分类号： C07D475/08 , A61K9/00 , A61K9/10 , A61K9/127 , A61K31/435 , A61K31/505 , A61K31/519 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/715 , A61K45/00 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , A61P35/00 , B01J13/02 , B01J13/04 , C07D519/00 , C07H15/252 , C07H19/09
CPC分类号： A61K9/1277 , A61K9/1271 , A61K9/1278
摘要： Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. Freezing of the liposome preparation prior to dehydration is optional. Alternatively, the protective sugar can be omitted if: (1) the liposomes are of the type which have multiple lipid layers; (2) the dehydration is done without prior freezing; and (3) the dehydration is performed to an end point which results in sufficient water being left in the preparation (e.g., at least 12 moles water/mole lipid) so that the integrity of a substantial portion of the multiple lipid layers is retained upon rehydration. Concentration gradients capable of generating transmembrane potentials can be created across the liposome membranes either before or after dehydration, and the transmembrane potentials resulting from these gradients can be used to load charged materials, e.g., drugs, into the liposomes.
摘要翻译： 通过在一种或多种保护性糖例如二糖类海藻糖和蔗糖的存在下，减压干燥脂质体制剂来制备脱水脂质体。 优选地，保护性糖存在于脂质体膜的内表面和外表面。 在脱水之前冻干脂质体制剂是任选的。 或者，如果：（1）脂质体是具有多个脂质层的类型，则可以省略保护性糖; （2）脱水是在没有预先冻结的情况下进行的; 和（3）脱水进行到终点，导致制剂中留有足够的水（例如，至少12摩尔水/摩尔脂质），使得大部分多脂质层的完整性保持在 补液。 可以在脱水之前或之后在脂质体膜上产生能够产生跨膜电位的浓度梯度，并且由这些梯度产生的跨膜电位可用于将带电材料（例如药物）加载到脂质体中。
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公开(公告)号：US20100173014A1
公开(公告)日：2010-07-08
申请号：US12601792
申请日：2007-05-24
申请人： Michael W. Fountain
发明人： Michael W. Fountain
IPC分类号： A61K33/14 , A61K31/194 , A61K31/661 , A61K31/522 , A61P3/02 , A61P3/12 , B01J13/02
CPC分类号： A61K9/127 , A61K9/006 , A61K9/0095
摘要： The instant invention discloses methods of preparing phospholipid delivery systems encapsulating one or more bio-affecting compounds, said methods comprising solubilizing a heterogeneous phospholipid mixture into a suitable organic solvent to form a concentrated formulation of phospholipids, wherein the phospholipids comprise a charged phospholipid species, and mixing the concentrated formulation with an aqueous solution comprising at least one bio-affecting compound. The instant invention also discloses methods of using a phospholipid delivery system encapsulating at least one bio-affecting compound for administration to an individual in need thereof.
摘要翻译： 本发明公开了制备包封一种或多种生物影响化合物的磷脂递送系统的方法，所述方法包括将非均相磷脂混合物溶解到合适的有机溶剂中以形成磷脂的浓缩制剂，其中磷脂包含带电磷脂物质，和 将浓缩的制剂与包含至少一种生物影响化合物的水溶液混合。 本发明还公开了将包含至少一种生物影响化合物的磷脂递送系统用于给予有需要的个体的方法。
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公开(公告)号：US20070154539A1
公开(公告)日：2007-07-05
申请号：US11644281
申请日：2006-12-22
申请人： Michael W. Fountain
发明人： Michael W. Fountain
IPC分类号： A61K9/127
CPC分类号： A61K9/5123 , A61K8/14 , A61K8/42 , A61K8/4953 , A61K8/553 , A61K8/602 , A61K8/67 , A61K8/673 , A61K9/0014 , A61K9/0053 , A61K9/1075 , A61K9/127 , A61K9/1271 , A61K9/14 , A61K9/51 , A61K9/5107 , A61K31/122 , A61K31/167 , A61K31/375 , A61K31/522 , A61K31/7048 , A61K31/714 , A61K2800/10 , A61K2800/413 , A61K2800/92 , A61Q19/00 , Y10S977/773 , Y10S977/797 , Y10S977/906 , Y10S977/907
摘要： Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.
摘要翻译： 平均直径为1nm〜20nm的纳米脂质颗粒（NLP）由前体溶液制成。 NLP可以装载所需的乘客分子。 称为NLP组件的这些颗粒的组件导致具有所需尺寸的车辆总体。 单一应用或多功能NLP组件由加载的NLP制成，尺寸范围为约30至约200nm。 使用预加载的NLP来制造更大载体载体或混合群体的方法提供了提高的包封效率。 NLP适用于化妆品，制药和食品饮料行业。
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公开(公告)号：US5879703A
公开(公告)日：1999-03-09
申请号：US507401
申请日：1996-01-02
申请人： Michael W. Fountain
发明人： Michael W. Fountain
CPC分类号： A61K9/1278 , A61K39/39 , A61K9/1271 , A61K2039/541 , A61K2039/55555 , Y10S514/937
摘要： A method for preparation of a shelf-stable precursor solution used to prepare a vaccine delivery system and useful for remote encapsulation of active ingredients is described. The vaccine delivery system utilizes solvent dilution microcarriers into which pathogen subunits are incorporated for delivering antigens to mucosal sites for stimulating imunoglobulin production.
摘要翻译： PCT No.PCT / US94 / 02053 Sec。 371日期1996年1月2日 102（e）日期1996年1月2日PCT 1994年2月25日PCT PCT。 公开号WO94 / 18950 PCT 日期1994年9月1日描述了制备用于制备疫苗递送系统并可用于远程包装活性成分的储存稳定的前体溶液的方法。 疫苗递送系统使用溶剂稀释微载体，其中引入病原体亚基以将抗原递送至粘膜部位以刺激免疫球蛋白产生。
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公开(公告)号：US5837279A
公开(公告)日：1998-11-17
申请号：US450831
申请日：1995-05-25
申请人： Andrew S. Janoff , Pieter R. Cullis , Marcel B. Bally , Michael W. Fountain , Richard S. Ginsberg , Michael J. Hope , Thomas D. Madden , Hugh P. Schieren , Regina L. Jablonski
发明人： Andrew S. Janoff , Pieter R. Cullis , Marcel B. Bally , Michael W. Fountain , Richard S. Ginsberg , Michael J. Hope , Thomas D. Madden , Hugh P. Schieren , Regina L. Jablonski
IPC分类号： C07D475/08 , A61K9/00 , A61K9/10 , A61K9/127 , A61K31/435 , A61K31/505 , A61K31/519 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/715 , A61K45/00 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , A61P35/00 , B01J13/02 , B01J13/04 , C07D519/00 , C07H15/252 , C07H19/09
CPC分类号： A61K9/1277 , A61K9/1271 , A61K9/1278
摘要： Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. Freezing of the liposome preparation prior to dehydration is optional. Alternatively, the protective sugar can be omitted if: (1) the liposomes are of the type which have multiple lipid layers; (2) the dehydration is done without prior freezing; and (3) the dehydration is performed to an end point which results in sufficient water being left in the preparation (e.g., at least 12 moles water/mole lipid) so that the integrity of a substantial portion of the multiple lipid layers is retained upon rehydration. Concentration gradients capable of generating transmembrane potentials can be created across the liposome membranes either before or after dehydration, and the transmembrane potentials resulting from these gradients can be used to load charged materials, e.g., drugs, into the liposomes.
摘要翻译： 通过在一种或多种保护性糖例如二糖类海藻糖和蔗糖的存在下，减压干燥脂质体制剂来制备脱水脂质体。 优选地，保护性糖存在于脂质体膜的内表面和外表面。 在脱水之前冻干脂质体制剂是任选的。 或者，如果：（1）脂质体是具有多个脂质层的类型，则可以省略保护性糖; （2）脱水是在没有预先冻结的情况下进行的; 和（3）脱水进行到终点，导致制剂中留有足够的水（例如，至少12摩尔水/摩尔脂质），使得大部分多脂质层的完整性保持在 补液。 可以在脱水之前或之后在脂质体膜上产生能够产生跨膜电位的浓度梯度，并且由这些梯度产生的跨膜电位可用于将带电材料（例如药物）加载到脂质体中。
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公开(公告)号：US5269979A
公开(公告)日：1993-12-14
申请号：US882801
申请日：1992-05-14
申请人： Michael W. Fountain
发明人： Michael W. Fountain
IPC分类号： A01N25/04 , A01N25/28 , A23L27/00 , A61K8/14 , A61K8/67 , A61K9/107 , A61K9/127 , A61Q19/00 , A61K9/12 , B01J13/02
CPC分类号： A01N25/04 , A01N25/28 , A23L27/72 , A61K8/14 , A61K8/671 , A61K9/1075 , A61K9/127 , A61Q19/00 , A61Q11/00 , A61Q13/00 , A61Q19/10 , A61Q5/06
摘要： A method for forming vehicles for encapsulating passenger molecules which have been named solvent dilution microcarriers (SDMCs), and the products of this process, are disclosed which allows for immediate or delayed formation of the encapsulating vehicles following creation of a shelf-stable formed solution by dissolution of amphipathic bilayer-forming materials, appropriate solvent, and the passenger molecule, addition of aqueous solution, and further addition of solvent. The SDMCs are organized from the formed solution by dilution into an aqueous system, aerosolization, or rehydration in situ.
摘要翻译： 公开了一种用于形成用于封装已被称为溶剂稀释微载体（SDMC）的乘客分子的载体的方法和该方法的产物，其允许立即或延迟形成包封载体，在形成稳定的成形溶液之后， 溶解两亲性双层形成材料，适当的溶剂和乘客分子，加入水溶液，并进一步加入溶剂。 SDMC通过稀释成含水体系，气雾化或原位再水化从形成的溶液中组织。
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公开(公告)号：US4522803A
公开(公告)日：1985-06-11
申请号：US476496
申请日：1983-03-24
CPC分类号： A61K9/127 , Y10S436/829 , Y10T428/2984
摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.
摘要翻译： 描述了称为稳定的多层囊泡（SPLV）的新的和显着改进的脂质囊泡型，以及其制备方法。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。
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