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1.发明申请公开(公告)号：US20170198311A1
公开(公告)日：2017-07-13
申请号：US15279184
申请日：2016-09-28
CPC分类号： C12P5/007 , C12N1/12 , C12N1/14 , C12N1/20 , C12N9/1085 , C12N9/88 , C12N15/70 , C12P7/42 , C12Y203/01008 , C12Y205/01 , C12Y401/02009 , C12Y402/03027 , C12Y503/03002 , Y02P20/52
摘要： The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
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2.发明申请PRODUCTION OF ISOPRENE, ISOPRENOID, AND ISOPRENOID PRECURSORS USING AN ALTERNATIVE LOWER MEVALONATE PATHWAY 审中-公开使用替代的下层梅花路线生产异丙苯，异丙苯和异丙苯前驱物公开(公告)号：US20160002672A1
公开(公告)日：2016-01-07
申请号：US14654424
申请日：2013-12-20
发明人： Zachary Q. BECK , Jörg MAMPEL , Guido MEURER , Michael C. MILLER , Karl J. SANFORD , Dmitrii V. VAVILINE , Walter WEYLER , Gregory M. WHITED
CPC分类号： C12P5/007 , C07C11/18 , C07F9/09 , C12N9/1229 , C12N9/88 , C12P9/00 , C12Y207/04026 , C12Y401/01 , Y02E50/343
摘要： The invention provides for compositions and methods for the production of isoprene, isoprenoid precursor, and/or isoprenoids in cells via the expression (e.g., heterologous expression) of phosphomevalonate decarboxylases and/or isopentenyl kinases.
摘要翻译： 本发明提供了通过磷酸戊糖醛酸脱羧酶和/或异戊烯基激酶的表达（例如异源表达）在细胞中产生异戊二烯，类异戊二烯前体和/或类异戊二烯的组合物和方法。
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3.发明申请METHODS FOR INCREASING MICROBIAL PRODUCTION OF ISOPRENE, ISOPRENOIDS, AND ISOPRENOID PRECURSOR MOLECULES USING GLUCOSE AND ACETATE CO-METABOLISM 审中-公开使用葡萄糖和乙酸盐代谢来增加异丙肾上腺素，异丙肾上腺素和异丙肾上腺素分子的微生物生产的方法公开(公告)号：US20140335576A1
公开(公告)日：2014-11-13
申请号：US14279053
申请日：2014-05-15
摘要： Provided herein are methods for the increased production of intracellular acetyl-CoA, mevalonate, isoprenoid precursors, isoprene and/or isoprenoids by recombinant microorganisms via co-metabolism of substrates with varied oxidation levels.
摘要翻译： 本文提供了通过重组微生物通过具有不同氧化水平的底物的共代谢增加细胞内乙酰辅酶A，甲羟戊酸，类异戊二烯前体，异戊二烯和/或类异戊二烯的生产的方法。
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公开(公告)号：US20140162337A1
公开(公告)日：2014-06-12
申请号：US13940092
申请日：2013-07-11
发明人： Gopal K. CHOTANI , Joseph C. MCAULIFFE , Michael C. MILLER , Rachel E. MUIR , Dmitrii V. VAVILINE , Walter WEYLER
摘要： The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.
摘要翻译： 本发明提供了使用DXP途径和MVA途径的各种组分或与DXP途径和MVA途径相关的组分，铁 - 硫簇相互作用的氧化还原多肽和异戊二烯合酶从培养细胞产生异戊二烯的方法。 本发明还提供包括这些培养细胞的组合物。
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5.发明申请INCREASED ISOPRENE PRODUCTION USING THE ARCHAEAL LOWER MEVALONATE PATHWAY 审中-公开使用ARCHAEAL LOWER MEVALONATE PATHWAY增加的ISOPRENE生产公开(公告)号：US20150203873A1
公开(公告)日：2015-07-23
申请号：US14323596
申请日：2014-07-03
发明人： Zachary Q. BECK , Anthony R. CALABRIA , Michael C. MILLER , Alex T. NIELSEN , Dmitrii V. VAVILINE
CPC分类号： C12P5/007 , C12N9/1205 , C12N9/88 , C12P9/00 , C12Y207/01036 , C12Y402/03027 , Y02P20/52
摘要： The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
摘要翻译： 本发明的特征在于使用反馈抗性甲羟戊酸激酶多肽（例如古细菌甲羟戊酸激酶多肽）从培养细胞产生异戊二烯的方法。 得到的异戊二烯组合物可以具有增加的异戊二烯的产率和/或纯度。
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公开(公告)号：US20130280769A1
公开(公告)日：2013-10-24
申请号：US13730661
申请日：2012-12-28
发明人： Zachary Q. BECK , Anthony R. CALABRIA , Michael C. MILLER , Alex T. NIELSEN , Dmitrii V. VAVILINE
CPC分类号： C12P5/007 , C12N9/1205 , C12N9/88 , C12P9/00 , C12Y207/01036 , C12Y402/03027 , Y02P20/52
摘要： The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
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7.发明申请METHODS FOR INCREASING MICROBIAL PRODUCTION OF ISOPRENE, ISOPRENOIDS, AND ISOPRENOID PRECURSOR MOLECULES USING GLUCOSE AND ACETATE CO-METABOLISM 审中-公开使用葡萄糖和乙酸盐代谢来增加异丙肾上腺素，异丙肾上腺素和异丙肾上腺素分子的微生物生产的方法公开(公告)号：US20130273625A1
公开(公告)日：2013-10-17
申请号：US13646556
申请日：2012-10-05
申请人： Danisco US Inc.
IPC分类号： C12P5/02
摘要： Provided herein are methods for the increased production of intracellular acetyl-CoA, mevalonate, isoprenoid precursors, isoprene and/or isoprenoids by recombinant microorganisms via co-metabolism of substrates with varied oxidation levels.
摘要翻译： 本文提供了通过重组微生物通过具有不同氧化水平的底物的共代谢增加细胞内乙酰辅酶A，甲羟戊酸，类异戊二烯前体，异戊二烯和/或类异戊二烯的生产的方法。
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公开(公告)号：US20130164808A1
公开(公告)日：2013-06-27
申请号：US13725929
申请日：2012-12-21
申请人： Danisco US Inc.
发明人： Joseph C. MCAULIFFE , Rachel E. MUIR , Alex T. NIELSEN , Caroline M. PERES , Dmitrii V. VAVILINE , Derek H. WELLS
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , C12N9/1085 , C12N9/88 , C12Y205/01001 , C12Y402/03027 , Y02P20/52
摘要： This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
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