公开(公告)号：US20030232333A1

公开(公告)日：2003-12-18

申请号：US10045674

申请日：2001-10-25

Applicant: Dyax Corp.

Inventor： Robert C. Ladner ,  Edward H. Cohen ,  Horacio G. Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C12Q001/68 ,  C12P019/34

CPC classification number: C07K16/005 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/622 ,  C12N15/10 ,  C12N15/1037 ,  C12N15/1093 ,  C12N15/66 ,  C40B40/02 ,  C40B40/08

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

Abstract translation: 用于构建共同显示和/或表达肽，多肽或蛋白质不同家族成员的文库的方法和使用这些方法产生的文库。 筛选这些文库和通过这种筛选鉴定的肽，多肽或蛋白质的方法。

公开(公告)号：US20040180422A1

公开(公告)日：2004-09-16

申请号：US10723981

申请日：2003-11-26

Applicant: DYAX CORP.

Inventor： Rene Hoet ,  Robert Charles Ladner ,  Nicolas Frans

IPC: C12N005/02 ,  C12N005/00 ,  C12N007/01 ,  C12N007/00 ,  C07H021/04 ,  C12Q001/70

CPC classification number: C40B40/02 ,  C12N7/00 ,  C12N15/1037 ,  C12N15/86 ,  C12N2795/00022 ,  C12N2795/00043 ,  C12N2830/002 ,  C12N2830/38 ,  C12N2830/55

Abstract: Disclosed are methods and compositions useful, e.g., for controlling the valency of display proteins during display library screenings and selections. In one embodiment, they are applicable to phage and phage libraries that are based on bacteriophage, e.g., filamentous bacteriophage.

Abstract translation: 公开了可用于例如显示库筛选和显示库筛选期间显示蛋白质的价态的方法和组合物。 在一个实施方案中，它们可应用于基于噬菌体的噬菌体和噬菌体文库，例如丝状噬菌体。