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公开(公告)号：US12049617B2
公开(公告)日：2024-07-30
申请号：US17050626
申请日：2019-05-21
申请人： DSM IP Assets B.V.
发明人： Christopher Mark Farrell , Lisa Ann Laprade , Otto Martin Lehmann , Joshua Trueheart , Bastien Jean Wolfgang Chevreux
摘要： The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.
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公开(公告)号：US12018309B2
公开(公告)日：2024-06-25
申请号：US17051610
申请日：2019-05-21
申请人： DSM IP ASSETS B.V.
发明人： Christopher Mark Farrell , Lisa Ann Laprade , Otto Martin Lehmann , Joshua Trueheart , Bastien Jean Wolfgang Chevreux
CPC分类号： C12P33/02 , C12N1/165 , C12N9/0071 , C12R2001/645
摘要： The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified host strains expressing enzymes having improved C-5 sterol 5 desaturase activity and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
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公开(公告)号：US11911405B2
公开(公告)日：2024-02-27
申请号：US17292132
申请日：2019-11-08
申请人： DSM IP Assets B.V.
发明人： Stephane Duval , John Michael Geremia , Lisa Ann Laprade , April Waguespack-Levy , Estefania Perez Calvo , Ghislain Schyns , Viviane Verlhac , Joshua Thomas Claypool
IPC分类号： A61K31/702 , A23K20/163 , A23K50/30 , A23K50/75
CPC分类号： A61K31/702 , A23K20/163 , A23K50/30 , A23K50/75
摘要： The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating the microbial species present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level or function of microbial species.
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公开(公告)号：US20240099274A1
公开(公告)日：2024-03-28
申请号：US17769096
申请日：2020-10-15
申请人： DSM IP Assets B.V.
发明人： Leticia Cardoso Bittencourt , Aaron Cowieson , Shelby P. Corray , Thomas J. Frost , Lisa Ann Laprade , Matthew Livingston , Rual Lopez Ulibarri , Estefania Perez Calvo , Yun-Ting Wang
IPC分类号： A01K39/012
CPC分类号： A01K39/012
摘要： The present invention relates to a preferably computer-implemented method of raising a group of monogastric animals Issues such as exposure of the animals to an initiator of a disease are recognized at an early stage by ex vivo analysis of blood samples. Said analysis is done where the animals are raised using point-of-care devices. Accuracy of separation between affected and non-affected animals is increased by measuring a set of pre-determined blood parameters. The landless monogastric animal production system of the invention facilitates implementation of the method of the invention.
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公开(公告)号：US11655267B2
公开(公告)日：2023-05-23
申请号：US17292119
申请日：2019-11-08
申请人： DSM IP Assets B.V.
发明人： Manuela Baur , Estel Canet-Martinez , Ruediger Hainz , Ulrich Hoeller , Lisa Ann Laprade , John Michael Geremia , Ghislain Schyns
摘要： The present disclosure relates oligosaccharide preparations suitable for use in nutritional compositions such as animal feed and methods of manufacturing the described oligosaccharide preparations. The present disclosure further relates to nutritional compositions that comprise the oligosaccharide preparations. The disclosed oligosaccharide preparations can be advantageous as an animal feed due to, at least in part, their prebiotic utility and the presence of anhydro-subunit containing oligosaccharides, which can be used to detect and/or determine the presence and content of the disclosed oligosaccharide preparations in the nutritional composition.
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