- 专利标题: Optimization of C-8 sterol isomerization
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申请号: US17050626申请日: 2019-05-21
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公开(公告)号: US12049617B2公开(公告)日: 2024-07-30
- 发明人: Christopher Mark Farrell , Lisa Ann Laprade , Otto Martin Lehmann , Joshua Trueheart , Bastien Jean Wolfgang Chevreux
- 申请人: DSM IP Assets B.V.
- 申请人地址: NL Heerlen
- 专利权人: DSM IP Assets B.V.
- 当前专利权人: DSM IP Assets B.V.
- 当前专利权人地址: NL Heerlen
- 代理机构: Nixon & Vanderhye, PC
- 优先权: CH 62618 2018.05.22
- 国际申请: PCT/EP2019/063080 2019.05.21
- 国际公布: WO2019/224190A 2019.11.28
- 进入国家日期: 2020-10-26
- 主分类号: C12N1/16
- IPC分类号: C12N1/16 ; C12N9/90 ; C12P33/00
摘要:
The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.
公开/授权文献
- US20210238539A1 OPTIMIZATION OF C-8 STEROL ISOMERIZATION 公开/授权日:2021-08-05
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