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    INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF
    4.
    发明申请
    INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF 有权

    公开(公告)号：US20220089611A1

    公开(公告)日：2022-03-24

    申请号：US17418353

    申请日：2019-12-27

    申请人： Dana-Farber Cancer Institute, Inc.

    发明人： Nathanael S. Gray ,  Tinghu Zhang ,  Nicholas Paul Kwiatkowski ,  Jie Jiang ,  Mingfeng Hao ,  Zhixiang He

    IPC分类号： C07D519/00 ,  C07D487/04

    摘要： The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds of the present disclosure are inhibitors of kinases (e.g., a cyclin-dependent kinase (CDK) (e.g., CDK7)). The compounds may be selective for inhibiting the activity of a kinase (e.g., CDK7) over certain other kinases (e.g., CDK2, CDK9, CDK12). Also provided are pharmaceutical compositions, kits, methods of use, and uses that involve the compounds. The compounds may be useful in inhibiting the activity of a kinase, down-regulating the transcription of MYC or MCL-1, inhibiting the growth of a cell, inducing apoptosis of a cell, treating a disease, and/or preventing a disease (e.g., proliferative disease, cystic fibrosis).