公开(公告)号：US20220378919A1

公开(公告)日：2022-12-01

申请号：US17761096

申请日：2020-09-24

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： Nathanael S. Gray ,  Jinhua Wang ,  Fleur Marcia Ferguson ,  Jie Jiang ,  Inchul You

IPC分类号： A61K47/54 ,  A61K47/55

摘要： Disclosed are bispecific compounds (degraders) that target ERK5 for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat cancer and inflammatory diseases.

公开(公告)号：US20240285777A1

公开(公告)日：2024-08-29

申请号：US18566929

申请日：2022-06-07

申请人： The General Hospital Corporation ,  Dana-Farber Cancer Institute, Inc.

发明人： Stephen John Haggarty ,  Maria Catarina Telo Baptista Lima Da Silva ,  Fleur Marcia Ferguson ,  Nathanael S. Gray

IPC分类号： A61K47/55 ,  A61K47/54 ,  A61P25/28

CPC分类号： A61K47/55 ,  A61K47/542 ,  A61P25/28

摘要： The present application provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the compound of Formula (I), and methods of using said compound and said compositions for treating neurodegenerative diseases, are also provided.