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    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    1.
    发明授权
    Inhibitors of cyclin-dependent kinase 7 (CDK7) 有权

    公开(公告)号：US10787436B2

    公开(公告)日：2020-09-29

    申请号：US16130975

    申请日：2018-09-13

    申请人： Dana-Farber Cancer Institute, Inc.

    发明人： Nathanael Gray ,  Tinghu Zhang ,  Nicholas Paul Kwiatkowski

    IPC分类号： C07D403/04 ,  A61K31/635 ,  A61K31/506 ,  C07D401/04 ,  C07D471/04 ,  A61K45/06 ,  A61K31/4439 ,  C07D417/04 ,  C07D513/04 ,  G01N33/50

    摘要： The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

    RAS INHIBITORS AND USES THEREOF
    6.
    发明申请
    RAS INHIBITORS AND USES THEREOF 审中-公开
    RAS抑制剂及其用途

    公开(公告)号：US20160046661A1

    公开(公告)日：2016-02-18

    申请号：US14775162

    申请日：2014-03-13

    申请人： DANA-FARBER CANCER INSTITUTE, INC.

    发明人： Nathanael Gray ,  Sang Min Lim ,  Hwan Geun Choi ,  Kenneth Dale Westover

    IPC分类号： C07H19/16 ,  C07F9/6561 ,  C07H19/20

    摘要： Described herein are compounds of Formulae (I)-(II), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases such as cancers (e.g., lung cancer, large bowel cancer, pancreas cancer, biliary tract cancer, or endometrial cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases in a subject.

    摘要翻译： 本文描述了式（I） - （II）的化合物及其药学上可接受的盐及其药物组合物。 还提供了涉及用于治疗或预防增殖性疾病如癌症（例如肺癌，大肠癌，胰腺癌，胆道癌或子宫内膜癌），良性肿瘤，血管生成，炎性疾病的本发明化合物或组合物的方法和试剂盒 ，自身炎症性疾病和自身免疫性疾病。