- 专利标题： DEGRADERS OF KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 (KEAP1)
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申请号： US17601536申请日： 2020-04-07
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公开(公告)号： US20220177466A1公开(公告)日： 2022-06-09
- 发明人: Nathanael Gray , Tinghu Zhang , Guangyan Du , Nathaniel Henning , Jie Jiang , Eric Fischer , Katherine Donovan
- 申请人： DANA-FARBER CANCER INSTITUTE, INC.
- 申请人地址： US MA Boston
- 专利权人： DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人： DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人地址： US MA Boston
- 国际申请： PCT/US2020/027067 WO 20200407
- 主分类号： C07D419/04
- IPC分类号： C07D419/04 ; C07D401/14 ; C07D401/04 ; A61K47/54
摘要：
The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions mediated by Kelch-like ECH-associated protein 1 (KEAP1). In some aspects, the present invention is directed to methods of treating diseases or disorders involving dysfunctional (e.g., dysregulated) KEAP1 activity, that entails administration of a therapeutically effective amount of a bifunctional compound of formula I or a pharmaceutically acceptable salt or stereoisomer thereof, to a subject in need thereof.
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