公开(公告)号：US09206412B2

公开(公告)日：2015-12-08

申请号：US13907485

申请日：2013-05-31

Applicant: Colorado State University Research Foundation ,  State of Colorado acting by and on behalf of the Board of Trustees of the University of Northern Colorado

Inventor： Brian J. Geiss ,  Susan M. Keenan ,  Hillary Jo Beek

IPC: A61K31/425 ,  C12N9/99 ,  C12N7/00 ,  C12N9/12 ,  A61K31/426 ,  A61K9/00 ,  A61K9/06 ,  A61K9/20 ,  A61K9/48 ,  A61K31/427

CPC classification number: C12N9/99 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/426 ,  A61K31/427 ,  C12N7/00 ,  C12N9/1241 ,  C12N2770/24122 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  A61K2300/00

Abstract: The invention provides methods to inhibit the replication of a flavivirus, methods of inhibiting the guanosine triphosphate (GTP)-binding and guanylyltransferase activity of a flavivirus RNA capping enzyme, and methods of treating a subject infected with a flavivirus. The methods can include contacting a flavivirus with an effective amount of a thioxothiazolidine compound described herein, or a derivative thereof, such as a compound of Formula (I).

Abstract translation: 本发明提供了抑制黄病毒的复制的方法，抑制黄病毒RNA封端酶的三磷酸鸟苷（GTP）结合和鸟苷酰基转移酶活性的方法，以及治疗感染黄病毒的受试者的方法。 所述方法可以包括将黄病毒与有效量的本文所述的噻唑并啶化合物或其衍生物如式（I）的化合物接触。

公开(公告)号：US20230294086A1

公开(公告)日：2023-09-21

申请号：US18016753

申请日：2021-07-29

Applicant: Colorado State University Research Foundation

Inventor： Charles S. Henry ,  Brian J. Geiss ,  David S. Dandy ,  Cody Carrell ,  Jeremy Link ,  Isabelle Samper ,  Ana Sanchez-Cano ,  Ilhoon Jang ,  Zachary Call

IPC: B01L3/00 ,  G01N33/543

CPC classification number: B01L3/5023 ,  G01N33/54388 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2400/0406 ,  B01L2300/069 ,  B01L2300/088

Abstract: An assay device includes a colorimetric testing assembly including a detection area, a fluid inlet, and a microfluidic network including a first path extending to the detection area and a second path extending to the detection area. When a fluid (e.g., a buffer fluid or a combined buffer and sample solution) is provided to the fluid inlet, a first portion of the fluid rehydrates a first dried reagent (e.g., a dried enzyme label) disposed along the first path to produce a first rehydrated reagent and a second portion of the fluid rehydrates a second dried reagent (e.g., a dried substrate) to produce a second rehydrated reagent. The first rehydrated reagent and the second rehydrated reagent are then sequentially delivered to the detection area by capillary-driven flow to perform the assay.