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公开(公告)号：US10653783B2
公开(公告)日：2020-05-19
申请号：US15808374
申请日：2017-11-09
Applicant: Colorado School of Mines
Inventor： Melissa D. Krebs , Gulsu Sener Yildirim
IPC: A61K47/32 , C08F120/38 , C08J9/00 , A61K9/06 , A61K38/16 , C08F220/38
Abstract: Methods of producing microporous zwitterionic cryogels are described, wherein the cryogels are useful for sustaining release of therapeutic agents. The disclosed cryogels overcome several limitations associated with existing compositions, for example the disclosed cryogels have high loading efficiencies and a sustained release profile with minimal burst of up to 4 months or more. The characteristics of the disclosed cryogels can be varied by altering monomer (e.g. zwitterion) and crosslinker selection. The amount of monomer contained in the hydrogel may also be varied to aid in controlling the cryogel's chemistry.
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公开(公告)号：US20220332902A1
公开(公告)日：2022-10-20
申请号：US17716538
申请日：2022-04-08
Applicant: Colorado School of Mines , GelSana Therapeutics, Inc.
Inventor： Melissa D. Krebs , Michael A. Stager , Matthew Osmond , Matthew Davidson
IPC: C08J3/075 , C08F220/28 , C08F220/38 , A61L26/00
Abstract: The present invention provides radical crosslinked zwitterionic gels, methods of preparing the radical crosslinked zwitterionic gels, and methods of using the radical crosslinked zwitterionic gels for treating a wound.
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公开(公告)号：US20140377366A1
公开(公告)日：2014-12-25
申请号：US14312772
申请日：2014-06-24
Applicant: COLORADO SCHOOL OF MINES
Inventor： Melissa D. Krebs
IPC: C07K16/22 , A61K9/10 , A61K47/36 , A61K39/395 , A61K9/16
CPC classification number: C07K16/22 , A61K9/0019 , A61K9/06 , A61K9/1647 , A61K9/1652 , A61K47/36 , C07K2317/76
Abstract: Methods, processes, systems, and compositions for treating disease are disclosed. In some cases, the present disclosure provides for delivery of therapeutic agents, in an active form, to a localized area, over an extended period of time. In one embodiment, the disclosed composition may comprise a therapeutic agent and a biodegradable polymer and/or a biodegradable polymer microsphere.
Abstract translation: 公开了用于治疗疾病的方法，方法，系统和组合物。 在一些情况下，本公开提供了在延长的时间段内将活性形式的治疗剂递送至局部区域。 在一个实施方案中，所公开的组合物可以包含治疗剂和可生物降解的聚合物和/或可生物降解的聚合物微球体。
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Patent Agency Ranking
公开(公告)号：US20200297856A1
公开(公告)日：2020-09-24
申请号：US16762860
申请日：2018-11-06
Inventor： Karin A. Payne , Melissa D. Krebs
Abstract: The present invention relates to the unexpected discovery of compositions and methods for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of “bony bars” at the site of growth plate injury, thereby preventing growth arrest and/or deformity. In certain embodiments, the compositions comprise hydrogels comprising at least one biological factor capable of preventing bony bar formation.
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公开(公告)号：US10926000B2
公开(公告)日：2021-02-23
申请号：US15595310
申请日：2017-05-15
Applicant: Colorado School of Mines
Inventor： Jacqueline L. Harding , Melissa D. Krebs
IPC: A61L27/32 , C08G65/34 , C08F16/06 , C08L5/08 , C08L5/04 , C01B25/26 , A61L27/54 , C08L71/02 , C08F16/10 , A61K33/42 , A61K31/7088
Abstract: The present invention relates to a method for in situ biomimetic mineralization of polymeric hydrogels, where the incorporated CaP phase can be selectively tuned in chemical composition and morphology to mimic bone and dental mineral. The present invention also relates to a method to coat a substrate with apatite material, the resulting product and the use of the product.
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公开(公告)号：US20180221490A1
公开(公告)日：2018-08-09
申请号：US15808374
申请日：2017-11-09
Applicant: Colorado School of Mines
Inventor： Melissa D. Krebs , Gulsu Sener Yildirim
IPC: A61K47/32 , C08F120/38 , C08J9/00 , A61K9/06 , A61K38/16
CPC classification number: A61K47/32 , A61K9/06 , A61K38/16 , C08F120/38 , C08F220/38 , C08J9/0061 , C08J2201/026 , C08J2205/022 , C08J2205/044 , C08J2205/05 , C08J2207/10 , C08J2333/14 , C08F2220/382 , C08F2222/1013 , C08F222/385
Abstract: Methods of producing microporous zwitterionic cryogels are described, wherein the cryogels are useful for sustaining release of therapeutic agents. The disclosed cryogels overcome several limitations associated with existing compositions, for example the disclosed cryogels have high loading efficiencies and a sustained release profile with minimal burst of up to 4 months or more. The characteristics of the disclosed cryogels can be varied by altering monomer (e.g. zwitterion) and crosslinker selection. The amount of monomer contained in the hydrogel may also be varied to aid in controlling the cryogel's chemistry.
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公开(公告)号：US20220105200A1
公开(公告)日：2022-04-07
申请号：US17428447
申请日：2020-02-04
Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , COLORADO SCHOOL OF MINES , UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Inventor： Kenneth Liechty , Carlos Zgheib , Melissa D. Krebs , Lindel Dewberry , Sudipta Seal
IPC: A61K47/69 , A61K9/06 , A61K47/36 , A61K47/54 , A61K9/16 , A61K31/728 , A61K38/39 , A61K38/36 , A61K33/244 , A61K47/32
Abstract: Methods of treating, reducing the risk of, preventing, or alleviating a symptom of inflammation or inflammatory disease, including wounds, diabetic ulcer, and inflammatory bowel disease, by administration of gel-based delivery particles, such as zwitterionic copolymer cryogels or chitosan microgels, containing cerium oxide nanoparticles.
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公开(公告)号：US09657094B2
公开(公告)日：2017-05-23
申请号：US14312772
申请日：2014-06-24
Applicant: COLORADO SCHOOL OF MINES
Inventor： Melissa D. Krebs
CPC classification number: C07K16/22 , A61K9/0019 , A61K9/06 , A61K9/1647 , A61K9/1652 , A61K47/36 , C07K2317/76
Abstract: Methods, processes, systems, and compositions for treating disease are disclosed. In some cases, the present disclosure provides for delivery of therapeutic agents, in an active form, to a localized area, over an extended period of time. In one embodiment, the disclosed composition may comprise a therapeutic agent and a biodegradable polymer and/or a biodegradable polymer microsphere.
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