公开(公告)号：US09885644B2

公开(公告)日：2018-02-06

申请号：US14307269

申请日：2014-06-17

Applicant: Colorado School of Mines

Inventor： Tobias Sawetzki ,  David W. M. Marr ,  Charles Eggleton ,  Sanjay Desai

IPC: G01N3/02 ,  G02B21/32 ,  B01L3/00

CPC classification number: G01N3/02 ,  B01L3/502761 ,  G01N2203/0089 ,  G02B21/32

Abstract: The present invention generally relates to a method for determining the dynamic viscoelastic properties of cells, more particularly to a method for rapidly determining the dynamic viscoelastic properties of healthy and unhealthy cells by determining the phase shift be the application of a modulating force to the cells and the cells' response to the modulating force.

公开(公告)号：US10722250B2

公开(公告)日：2020-07-28

申请号：US15069681

申请日：2016-03-14

Applicant: Colorado School of Mines

Inventor： Tonguc Onur Tasci ,  Keith B. Neeves ,  David W. M. Marr

IPC: A61B17/22 ,  A61B34/00 ,  A61B17/3207 ,  A61M37/00 ,  A61B17/00 ,  A61B34/30

Abstract: The invention relates to a magnetic-field driven colloidal microbot that employs wall-based propulsion, method of forming the microbot and a method of using the microbot. The microbot can be formed in situ with the use of magnetic fields, and the magnetic fields can be used to translate the microbot to a specified location in a patient. The microbot does not depend on “swimming” or flow currents within a patient to move, but instead can propel itself along a surface using a magnetic field. Once the magnetic field is removed, the microbot disassembles into colloidal particles.

公开(公告)号：US09487812B2

公开(公告)日：2016-11-08

申请号：US13770875

申请日：2013-02-19

Applicant: Colorado School of Mines

Inventor： Keith B. Neeves ,  David W. M. Marr ,  Kevin B. Roth ,  Charles D. Eggleton

IPC: B01L99/00 ,  G01N15/14 ,  C12Q1/02 ,  B01L3/00

CPC classification number: C12Q1/02 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0463 ,  B01L2400/0487 ,  G01N15/1484 ,  G01N2015/1495

Abstract: A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel, each of which are carrying one or more objects. There is an intersection between the first and second microfluidic channels where one or more objects from the first microfluidic channel impact one or more objects from the second microfluidic channel under hydrodynamic forces. The impact causes the objects to deform and the deformation of objects can be analyzed to determine properties of the object.

Abstract translation: 公开了微流体系统，装置和方法。 微流体系统可以包括第一微流体通道和第二微流体通道，每个通道都携带一个或多个物体。 在第一和第二微流体通道之间存在交叉点，其中来自第一微流体通道的一个或多个物体在流体动力作用下冲击来自第二微流体通道的一个或多个物体。 冲击会导致物体变形，并且可以分析物体的变形以确定物体的属性。